P0CL66 · OSPA_BORBU

Function

function

Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells (PubMed:10426995).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell outer membrane
Cellular Componentcell surface
Cellular Componentmembrane

Names & Taxonomy

Protein names

  • Recommended name
    Outer surface protein A

Gene names

    • Name
      ospA
    • Ordered locus names
      BB_A15

Encoded on

  • Plasmid lp54

Organism names

Accessions

  • Primary accession
    P0CL66
  • Secondary accessions
    • P0C926
    • P14013
    • Q44882
    • Q44964
    • Q44967

Proteomes

Subcellular Location

Cell outer membrane
; Lipid-anchor
Cell surface

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant35in strain: CA7
Natural variant39in strain: PBre and 21343WI
Natural variant59in strain: 42373NY3
Natural variant90in strain: CA8
Natural variant114in strain: PBre
Natural variant127in strain: CA8
Natural variant132-133in strain: CA8
Natural variant144in strain: 21343WI
Natural variant149in strain: PBre and 42373NY3
Natural variant164in strain: PBre
Natural variant196in strain: CA8 and 21343WI

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 11 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, lipidation, chain.

TypeIDPosition(s)Description
Signal1-16
Lipidation17N-palmitoyl cysteine
Lipidation17S-diacylglycerol cysteine
ChainPRO_000001807417-273Outer surface protein A

Keywords

Family & Domains

Sequence similarities

Belongs to the OspA lipoprotein family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    273
  • Mass (Da)
    29,367
  • Last updated
    2011-04-05 v1
  • Checksum
    B53FC01D92F6D431
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X14407
EMBL· GenBank· DDBJ
CAA32579.1
EMBL· GenBank· DDBJ
Genomic DNA
X85739
EMBL· GenBank· DDBJ
CAA59742.1
EMBL· GenBank· DDBJ
Genomic DNA
X80182
EMBL· GenBank· DDBJ
CAA56467.1
EMBL· GenBank· DDBJ
Genomic DNA
X69606
EMBL· GenBank· DDBJ
CAA49314.1
EMBL· GenBank· DDBJ
Genomic DNA
AE000790
EMBL· GenBank· DDBJ
AAC66260.1
EMBL· GenBank· DDBJ
Genomic DNA
L23136
EMBL· GenBank· DDBJ
AAA22951.1
EMBL· GenBank· DDBJ
Genomic DNA
L23137
EMBL· GenBank· DDBJ
AAA22953.1
EMBL· GenBank· DDBJ
Genomic DNA
L23138
EMBL· GenBank· DDBJ
AAA20947.1
EMBL· GenBank· DDBJ
Genomic DNA
L23139
EMBL· GenBank· DDBJ
AAA20949.1
EMBL· GenBank· DDBJ
Genomic DNA
L23140
EMBL· GenBank· DDBJ
AAA20951.1
EMBL· GenBank· DDBJ
Genomic DNA
L23141
EMBL· GenBank· DDBJ
AAA20953.1
EMBL· GenBank· DDBJ
Genomic DNA
L23142
EMBL· GenBank· DDBJ
AAA20955.1
EMBL· GenBank· DDBJ
Genomic DNA
L23143
EMBL· GenBank· DDBJ
AAA20957.1
EMBL· GenBank· DDBJ
Genomic DNA
L23144
EMBL· GenBank· DDBJ
AAA20959.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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