P0CL66 · OSPA_BORBU
- ProteinOuter surface protein A
- GeneospA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids273 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells (PubMed:10426995).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell outer membrane | |
Cellular Component | cell surface | |
Cellular Component | membrane |
Names & Taxonomy
Protein names
- Recommended nameOuter surface protein A
Gene names
Encoded on
- Plasmid lp54
Organism names
- Strains
- Taxonomic lineageBacteria > Spirochaetota > Spirochaetia > Spirochaetales > Borreliaceae > Borreliella
Accessions
- Primary accessionP0CL66
- Secondary accessions
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 35 | in strain: CA7 | ||||
Sequence: P → S | ||||||
Natural variant | 39 | in strain: PBre and 21343WI | ||||
Sequence: K → N | ||||||
Natural variant | 59 | in strain: 42373NY3 | ||||
Sequence: D → H | ||||||
Natural variant | 90 | in strain: CA8 | ||||
Sequence: I → V | ||||||
Natural variant | 114 | in strain: PBre | ||||
Sequence: V → A | ||||||
Natural variant | 127 | in strain: CA8 | ||||
Sequence: N → S | ||||||
Natural variant | 132-133 | in strain: CA8 | ||||
Sequence: VS → LP | ||||||
Natural variant | 144 | in strain: 21343WI | ||||
Sequence: R → K | ||||||
Natural variant | 149 | in strain: PBre and 42373NY3 | ||||
Sequence: G → E | ||||||
Natural variant | 164 | in strain: PBre | ||||
Sequence: G → S | ||||||
Natural variant | 196 | in strain: CA8 and 21343WI | ||||
Sequence: E → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 11 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, lipidation, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-16 | |||||
Sequence: MKKYLLGIGLILALIA | ||||||
Lipidation | 17 | N-palmitoyl cysteine | ||||
Sequence: C | ||||||
Lipidation | 17 | S-diacylglycerol cysteine | ||||
Sequence: C | ||||||
Chain | PRO_0000018074 | 17-273 | Outer surface protein A | |||
Sequence: CKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK |
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length273
- Mass (Da)29,367
- Last updated2011-04-05 v1
- ChecksumB53FC01D92F6D431
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X14407 EMBL· GenBank· DDBJ | CAA32579.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X85739 EMBL· GenBank· DDBJ | CAA59742.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X80182 EMBL· GenBank· DDBJ | CAA56467.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X69606 EMBL· GenBank· DDBJ | CAA49314.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE000790 EMBL· GenBank· DDBJ | AAC66260.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L23136 EMBL· GenBank· DDBJ | AAA22951.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L23137 EMBL· GenBank· DDBJ | AAA22953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L23138 EMBL· GenBank· DDBJ | AAA20947.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L23139 EMBL· GenBank· DDBJ | AAA20949.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L23140 EMBL· GenBank· DDBJ | AAA20951.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L23141 EMBL· GenBank· DDBJ | AAA20953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L23142 EMBL· GenBank· DDBJ | AAA20955.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L23143 EMBL· GenBank· DDBJ | AAA20957.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L23144 EMBL· GenBank· DDBJ | AAA20959.1 EMBL· GenBank· DDBJ | Genomic DNA |