P0CH33 · UBQ11_ARATH

Function

function

Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).

Miscellaneous

Ubiquitin is encoded by 16 different genes. Ubiquitin is generally synthesized as a polyubiquitin precursor with tandem head to tail repeats. Often, there is one to three additional amino acids after the last repeat, removed in the mature protein. Alternatively, ubiquitin extension protein is synthesized as a single copy of ubiquitin fused to a ribosomal protein (either eL40 or eS31) or to a ubiquitin-related protein (either RUB1 or RUB2). Following translation, extension protein is cleaved from ubiquitin.
For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular FunctionmRNA binding
Biological Processubiquitin-dependent protein catabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Polyubiquitin 11
  • Cleaved into 1 chains

Gene names

    • Name
      UBQ11
    • ORF names
      C17L7.6, T32N4.13
    • Ordered locus names
      At4g05050

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    P0CH33
  • Secondary accessions
    • O80715
    • P59263
    • Q38875
    • Q9LDJ2
    • Q9LYW1

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, cross-link, propeptide.

Type
IDPosition(s)Description
ChainPRO_00003968951-76Ubiquitin
Cross-link76Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
ChainPRO_000039689677-152Ubiquitin
ChainPRO_0000396897153-228Ubiquitin
PropeptidePRO_0000396898229

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-76Ubiquitin-like 1
Domain77-152Ubiquitin-like 2
Domain153-228Ubiquitin-like 3

Sequence similarities

Belongs to the ubiquitin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.

P0CH33-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    229
  • Mass (Da)
    25,685
  • Last updated
    2010-08-10 v1
  • Checksum
    DECF8BB1742D009E
MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGF

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q3EAA5Q3EAA5_ARATHUBQ10381
F4JGM3F4JGM3_ARATHUBQ11153

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF162444
EMBL· GenBank· DDBJ
AAD48980.1
EMBL· GenBank· DDBJ
Genomic DNA
AL161502
EMBL· GenBank· DDBJ
CAB81047.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE82468.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE82469.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE82470.1
EMBL· GenBank· DDBJ
Genomic DNA
AY052661
EMBL· GenBank· DDBJ
AAK96565.1
EMBL· GenBank· DDBJ
mRNA
AY054281
EMBL· GenBank· DDBJ
AAL06940.1
EMBL· GenBank· DDBJ
mRNA
AY057530
EMBL· GenBank· DDBJ
AAL09770.1
EMBL· GenBank· DDBJ
mRNA
AY098958
EMBL· GenBank· DDBJ
AAM19968.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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