P0CH33 · UBQ11_ARATH
- ProteinPolyubiquitin 11
- GeneUBQ11
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids229 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
Miscellaneous
Ubiquitin is encoded by 16 different genes. Ubiquitin is generally synthesized as a polyubiquitin precursor with tandem head to tail repeats. Often, there is one to three additional amino acids after the last repeat, removed in the mature protein. Alternatively, ubiquitin extension protein is synthesized as a single copy of ubiquitin fused to a ribosomal protein (either eL40 or eS31) or to a ubiquitin-related protein (either RUB1 or RUB2). Following translation, extension protein is cleaved from ubiquitin.
For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | mRNA binding | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended namePolyubiquitin 11
- Cleaved into 1 chains
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP0CH33
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
PTM/Processing
Features
Showing features for chain, cross-link, propeptide.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000396895 | 1-76 | Ubiquitin | ||
Cross-link | 76 | Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) | |||
Chain | PRO_0000396896 | 77-152 | Ubiquitin | ||
Chain | PRO_0000396897 | 153-228 | Ubiquitin | ||
Propeptide | PRO_0000396898 | 229 | |||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-76 | Ubiquitin-like 1 | |||
Domain | 77-152 | Ubiquitin-like 2 | |||
Domain | 153-228 | Ubiquitin-like 3 | |||
Sequence similarities
Belongs to the ubiquitin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.
P0CH33-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length229
- Mass (Da)25,685
- Last updated2010-08-10 v1
- ChecksumDECF8BB1742D009E
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF162444 EMBL· GenBank· DDBJ | AAD48980.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL161502 EMBL· GenBank· DDBJ | CAB81047.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE82468.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE82469.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE82470.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY052661 EMBL· GenBank· DDBJ | AAK96565.1 EMBL· GenBank· DDBJ | mRNA | ||
AY054281 EMBL· GenBank· DDBJ | AAL06940.1 EMBL· GenBank· DDBJ | mRNA | ||
AY057530 EMBL· GenBank· DDBJ | AAL09770.1 EMBL· GenBank· DDBJ | mRNA | ||
AY098958 EMBL· GenBank· DDBJ | AAM19968.1 EMBL· GenBank· DDBJ | mRNA |