P0CF51 · TRGC1_HUMAN

  • Protein
    T cell receptor gamma constant 1
  • Gene
    TRGC1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447).
Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588).
Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089).
Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).

GO annotations

AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentgamma-delta T cell receptor complex
Cellular Componentplasma membrane
Molecular Functionsmall molecule binding
Biological Processadaptive immune response
Biological Processgamma-delta T cell activation
Biological ProcessT cell receptor signaling pathway

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    T cell receptor gamma constant 1

Gene names

    • Name
      TRGC1
    • Synonyms
      TCRGC1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P0CF51
  • Secondary accessions
    • A0A075B6Q9

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane139-161Helical

Keywords

Disease & Variants

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00003934721-173T cell receptor gamma constant 1
Disulfide bond32↔88
Glycosylation66N-linked (GlcNAc...) asparagine
Glycosylation120N-linked (GlcNAc...) asparagine
Glycosylation126N-linked (GlcNAc...) asparagine
Glycosylation135N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Gamma-delta TR is a heterodimer composed of a gamma and delta chain; disulfide-linked. The gamma-delta TR is associated with the transmembrane signaling CD3 coreceptor proteins following the stoichiometry: a single gamma-delta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. Upon activation, gamma-delta TR complex associates with FCER1G to initiate intracellular signaling.
View interactors in UniProtKB
View CPX-6582 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-104Ig-like

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    173
  • Mass (Da)
    19,804
  • Last updated
    2010-04-20 v1
  • Checksum
    67C65AF5C03D33BB
DKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDVIKIHWQEKKSNTILGSQEGNTMKTNDTYMKFSWLTVPEKSLDKEHRCIVRHENNKNGVDQEIIFPPIKTDVITMDPKDNCSKDANDTLLLQLTNTSAYYMYLLLLLKSVVYFAIITCCLLRRTAFCCNGEKS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A2JGV3TARP_HUMANTRGC158
A0A5H1ZRQ6A0A5H1ZRQ6_HUMANTRGC1173

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Polymorphism

There are several alleles. The sequence shown is that of IMGT allele TRGC1*01.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M14998
EMBL· GenBank· DDBJ
AAA75392.1
EMBL· GenBank· DDBJ
Genomic DNA
M14996
EMBL· GenBank· DDBJ
AAA75392.1
EMBL· GenBank· DDBJ
Genomic DNA
M14997
EMBL· GenBank· DDBJ
AAA75392.1
EMBL· GenBank· DDBJ
Genomic DNA
AC006033
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp