P0CAX7 · MP83_MYCBO

Function

function

Induces expression of human (host) matrix metalloproteinase-9 (MMP9) in a TLR1/TLR2-dependent fashion; the acylated 20 first mature residues (residues 25-40) induce the most expression, but whole recombinant protein (non-acylated and non-glycosylated), and mannosylated but not acylated protein (residues 26-220) also induce expression (PubMed:20800577).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentplasma membrane

Names & Taxonomy

Protein names

  • Recommended name
    Cell surface glycolipoprotein MPB83
  • Alternative names
    • Lipoprotein p23

Gene names

    • Name
      mpb83
    • Ordered locus names
      BQ2027_MB2898

Organism names

Accessions

  • Primary accession
    P0CAX7
  • Secondary accessions
    • A0A1R3Y2F5
    • P0A671
    • P71493
    • Q10790
    • X2BM94

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis48-49No longer binds concanavalin A upon expression of residues 1-63 in M.smegmatis.

PTM/Processing

Features

Showing features for signal, lipidation, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-24
Lipidation25N-palmitoyl cysteine
Lipidation25S-diacylglycerol cysteine
ChainPRO_000000878725-220Cell surface glycolipoprotein MPB83
Glycosylation48O-linked (Man...) threonine
Glycosylation49O-linked (Man...) threonine

Post-translational modification

O-glycosylated. Contains 0-3 mannose residues attached to residues 48-49 in various configurations; the dominant glycoform is Thr-48(Man)/Thr-49(Man2) with an unusual Man(1->3)Man linkage, but Thr48(Man3)/Thr49(Man0) through to Thr48(Man0/)Thr49(Man3) are also seen (PubMed:12517764).
When isolated from culture filtrate runs as 25 and 23 kDa proteins; the larger protein is much less abundant, mostly associated with the cell and starts at residue 28, the shorter is more abundant and starts at residue 48 (PubMed:12517764).

Keywords

PTM databases

Interaction

Subunit

Interacts with host (human) TLR2 (PubMed:20800577).

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain83-215FAS1

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    220
  • Mass (Da)
    22,070
  • Last updated
    2009-07-07 v1
  • Checksum
    5CB99A4B51852A98
MINVQAKPAAAASLAAIAIAFLAGCSSTKPVSQDTSPKPATSPAAPVTTAAMADPAADLIGRGCAQYAAQNPTGPGSVAGMAQDPVATAASNNPMLSTLTSALSGKLNPDVNLVDTLNGGEYTVFAPTNAAFDKLPAATIDQLKTDAKLLSSILTYHVIAGQASPSRIDGTHQTLQGADLTVIGARDDLMVNNAGLVCGGVHTANATVYMIDTVLMPPAQ

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict36in Ref. 4; AA sequence

Mass Spectrometry

Molecular mass is 18,048 Da. Determined by Electrospray. For the shorter more abundant form, is tri-hexosylated.
Molecular mass is 17,560 Da. Determined by Electrospray. For the shorter more abundant form, chemically deglycosylated.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D64165
EMBL· GenBank· DDBJ
BAA11027.1
EMBL· GenBank· DDBJ
Genomic DNA
LT708304
EMBL· GenBank· DDBJ
SIU01519.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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