P0C8L0 · CYB_CANAL

Function

function

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:34525326, PubMed:36923588).
The complex plays an important role in the uptake of multiple carbon sources present in different host niches (PubMed:36923588).

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.

Caution

The protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme b groups non-covalently.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site82Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site96Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site183Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site197Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentheterochromatin
Cellular Componentmembrane
Cellular Componentmitochondrial respiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processmitochondrial electron transport, ubiquinol to cytochrome c

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b
  • Alternative names
    • Complex III subunit 3
    • Complex III subunit III
    • Cytochrome b-c1 complex subunit 3
    • Ubiquinol-cytochrome-c reductase complex cytochrome b subunit

Gene names

    • Name
      COB
    • Synonyms
      CYTB
    • ORF names
      CaalfMp11
    • Ordered locus names
      CM_00330W

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    P0C8L0

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane32-52Helical
Transmembrane85-105Helical
Transmembrane116-136Helical
Transmembrane151-171Helical
Transmembrane179-199Helical
Transmembrane225-245Helical
Transmembrane289-309Helical
Transmembrane324-344Helical
Transmembrane350-370Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Leads to lethality, showing that it is an essential gene.

Chemistry

Interaction

Subunit

Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III2IV and III2IV2).

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    387
  • Mass (Da)
    43,708
  • Last updated
    2008-12-16 v1
  • Checksum
    4F345A9AD99624F1
MPTRKSNTYLSLVNSYLIDSPQPSSINYWWNLGSLLGLCLVIQIASGVFLAMHYSSNIELAFDSVEHIMRDVNAGWLIRYIHANGASFFFICMYLHIGKALYYGSYKQPRVMLWVIGVVIFILTMAIAFMGYCLVYGQMSHWGATVITNLLSAIPFIGNDIVPFIWGGFSVSNPTIQRFFALHFLLPFILAALVCMHLMALHVHGSSNPVGITGNIDRLPMHPYFIFKDLITVFVFLLIFSLFVFYSPNTLGHPDNYIPGNPMVTPPSIVPEWYLLPFYAILRSIPDKLGGVIAMFGAILILLSLPYTDRSIIRGNSFKVLSKLAFYLFVFNFILLGNLGQLHVEVPYIQLGQFATAYYFAHYIIVVPVISTLENILYYIGTQTRVK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF285261
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp