P0C8L0 · CYB_CANAL
- ProteinCytochrome b
- GeneCOB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids387 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:34525326, PubMed:36923588).
The complex plays an important role in the uptake of multiple carbon sources present in different host niches (PubMed:36923588).
The complex plays an important role in the uptake of multiple carbon sources present in different host niches (PubMed:36923588).
Miscellaneous
Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
Cofactor
Note: Binds 2 heme b groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 82 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 96 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 183 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 197 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | heterochromatin | |
Cellular Component | membrane | |
Cellular Component | mitochondrial respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | mitochondrial electron transport, ubiquinol to cytochrome c |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionP0C8L0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 32-52 | Helical | ||||
Sequence: LGSLLGLCLVIQIASGVFLAM | ||||||
Transmembrane | 85-105 | Helical | ||||
Sequence: GASFFFICMYLHIGKALYYGS | ||||||
Transmembrane | 116-136 | Helical | ||||
Sequence: IGVVIFILTMAIAFMGYCLVY | ||||||
Transmembrane | 151-171 | Helical | ||||
Sequence: LSAIPFIGNDIVPFIWGGFSV | ||||||
Transmembrane | 179-199 | Helical | ||||
Sequence: FFALHFLLPFILAALVCMHLM | ||||||
Transmembrane | 225-245 | Helical | ||||
Sequence: FIFKDLITVFVFLLIFSLFVF | ||||||
Transmembrane | 289-309 | Helical | ||||
Sequence: LGGVIAMFGAILILLSLPYTD | ||||||
Transmembrane | 324-344 | Helical | ||||
Sequence: LAFYLFVFNFILLGNLGQLHV | ||||||
Transmembrane | 350-370 | Helical | ||||
Sequence: QLGQFATAYYFAHYIIVVPVI |
Keywords
- Cellular component
Phenotypes & Variants
Interaction
Subunit
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III2IV and III2IV2).
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length387
- Mass (Da)43,708
- Last updated2008-12-16 v1
- Checksum4F345A9AD99624F1
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF285261 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |