P0C8I7 · VM3FA_VIPAA

Function

function

Catalytic subunit of blood coagulation factor X-activating enzyme. Activates coagulation factor X (F10) in a calcium-dependent manner by cleaving at the '234-Arg-|-Ile-235' site. Weakly hydrolyzes insulin B chain (by cleaving at the '27-Asn-|-Gln-28' and '44-Gly-|-Glu-45' sites), fibrinogen and some components of the extracellular matrix in vitro.

Miscellaneous

Negative results: does not activate prothrombin or plasminogen.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site.

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LVSVSPAFNGNYFVE
TypeIDPosition(s)Description
Binding site11Ca2+ (UniProtKB | ChEBI)
Binding site13Ca2+ (UniProtKB | ChEBI)
Binding site15Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionmetal ion binding
Molecular Functionmetallopeptidase activity
Molecular Functiontoxin activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Factor X-activator 1 heavy chain
  • EC number
  • Short names
    VAFXA-I HC
  • Alternative names
    • Snake venom metalloproteinase (SVMP)

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Viperidae > Viperinae > Vipera

Accessions

  • Primary accession
    P0C8I7

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003552271-15Factor X-activator 1 heavy chain

Post-translational modification

N-glycosylated.

Keywords

Expression

Tissue specificity

Expressed by the venom gland.

Interaction

Subunit

Heterotrimer; disulfide-linked. The heterotrimer consists of 1 heavy chain and 2 light chains (lectins): LC1 (AC P0C8J2) and LC2 (AC P0C8J3).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-15Peptidase M12B

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    15
  • Mass (Da)
    1,643
  • Last updated
    2008-11-25 v1
  • Checksum
    D5429F469CD5A435
LVSVSPAFNGNYFVE

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue15

Keywords

Similar Proteins

Disclaimer

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