P0C8B1 · DEFBL_ORNAN
- ProteinVenom-like beta-defensin
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Potent antimicrobial peptide that displays activity against S.aureus and P.aeruginosa (PubMed:24694388).
Does not inhibit growth of E.coli (PubMed:24694388).
Does not inhibit growth of E.coli (PubMed:24694388).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Biological Process | defense response to bacterium |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameVenom-like beta-defensin
- Short namesDefB-vL ; Defensin-BvL ; OaDefB-vL
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Monotremata > Ornithorhynchidae > Ornithorhynchus
Accessions
- Primary accessionP0C8B1
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 25-28 | Decrease in antimicrobial potency, but no change in overall fold. | ||||
Sequence: Missing |
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MRLLILFLAVVTLLSLAGPGSAEV | ||||||
Chain | PRO_0000352730 | 25-68 | Venom-like beta-defensin | |||
Sequence: RRRRRRPPCEDVNGQCQPRGNPCLRLRGACPRGSRCCMPTVAAH | ||||||
Disulfide bond | 33↔60 | |||||
Sequence: CEDVNGQCQPRGNPCLRLRGACPRGSRC | ||||||
Disulfide bond | 40↔54 | |||||
Sequence: CQPRGNPCLRLRGAC | ||||||
Disulfide bond | 47↔61 | |||||
Sequence: CLRLRGACPRGSRCC |
Keywords
- PTM
Expression
Tissue specificity
Highly expressed in intestine, liver and spleen and expressed at lower levels in brain, kidney, lung, testis and venom gland.
Gene expression databases
Structure
Family & Domains
Domain
The 4 N-terminal Arg residues do not affect the overall fold, but are important for the antimicrobial potency.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length68
- Mass (Da)7,455
- Last updated2008-10-14 v1
- Checksum6F73547C6E116277
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6I8NPY1 | A0A6I8NPY1_ORNAN | 66 |
Keywords
- Technical term