P0C890 · MDH_PROVB

Function

function

Catalyzes the reversible oxidation of malate to oxaloacetate.

Catalytic activity

Features

Showing features for binding site, active site.

131020406080100120140160180200220240260280300
TypeIDPosition(s)Description
Binding site7-12NAD+ (UniProtKB | ChEBI)
Binding site32NAD+ (UniProtKB | ChEBI)
Binding site81substrate
Binding site87substrate
Binding site94NAD+ (UniProtKB | ChEBI)
Binding site117-119NAD+ (UniProtKB | ChEBI)
Binding site119substrate
Binding site150substrate
Active site174Proton acceptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionL-lactate dehydrogenase activity
Molecular FunctionL-malate dehydrogenase (NAD+) activity
Biological Processlactate metabolic process
Biological Processpyruvate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Malate dehydrogenase
  • EC number

Gene names

    • Name
      mdh

Organism names

Accessions

  • Primary accession
    P0C890
  • Secondary accessions
    • P80038
    • P94687

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001134491-310Malate dehydrogenase

Interaction

Subunit

Homotetramer; arranged as a dimer of dimers.

Family & Domains

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    310
  • Mass (Da)
    33,273
  • Last updated
    2008-10-14 v1
  • Checksum
    DFF3033B27FEC714
MKITVIGAGNVGATTAFRIADKKLARELVLLDVVEGIPQGKGLDMYETGPVGLFDTKITGSNDYADTADSDIVIITAGLPRKPGMTREDLLMKNAGIVKEVTDNIMKHSKNPIIIVVSNPLDIMTHVAWVRSGLPKERVIGMAGVLDAARFRSFIAMELGVSMQDINACVLGGHGDAMVPVVKYTTVAGIPISDLLPAETIDKLVERTRNGGAEIVEHLKQGSAFYSPGSSVVEMVESIVLDRKRVLPCAVGLEGQYGIDKTFVGVPVKLGRNGVEQIYEINLDQADLDLLQKSAKIVDENCKMLESTIG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X80837
EMBL· GenBank· DDBJ
CAA56809.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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