P0C7U5 · C5AR1_DANRE

Function

function

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical part of cell
Cellular Componentbasolateral plasma membrane
Cellular Componentplasma membrane
Molecular Functioncomplement component C5a receptor activity
Molecular Functioncomplement receptor activity
Molecular FunctionG protein-coupled receptor activity
Biological Processchemotaxis
Biological Processcomplement receptor mediated signaling pathway
Biological Processinflammatory response
Biological ProcessmRNA transcription by RNA polymerase II
Biological Processphospholipase C-activating G protein-coupled receptor signaling pathway
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of epithelial cell proliferation
Biological Processpositive regulation of ERK1 and ERK2 cascade

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    C5a anaphylatoxin chemotactic receptor 1
  • Alternative names
    • C5a anaphylatoxin chemotactic receptor (C5a-R; C5aR)

Gene names

    • Name
      c5ar1

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    P0C7U5

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-33Extracellular
Transmembrane34-60Helical; Name=1
Topological domain61-65Cytoplasmic
Transmembrane66-89Helical; Name=2
Topological domain90-106Extracellular
Transmembrane107-128Helical; Name=3
Topological domain129-149Cytoplasmic
Transmembrane150-170Helical; Name=4
Topological domain171-194Extracellular
Transmembrane195-220Helical; Name=5
Topological domain221-238Cytoplasmic
Transmembrane239-261Helical; Name=6
Topological domain262-279Extracellular
Transmembrane280-300Helical; Name=7
Topological domain301-346Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00003437951-346C5a anaphylatoxin chemotactic receptor 1
Glycosylation4N-linked (GlcNAc...) asparagine
Glycosylation15N-linked (GlcNAc...) asparagine
Disulfide bond105↔183

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region323-346Disordered
Compositional bias324-339Polar residues

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    346
  • Mass (Da)
    39,115
  • Last updated
    2008-07-22 v1
  • Checksum
    832164A475DCA5AA
MDDNNSDWTSYDFGNDTIPSPNEISLSHIGTRHWITLVCYGIVFLLGVPGNALVVWVTGFRMPNSVNAQWFLNLAIADLLCCLSLPILMVPLAQDQHWPFGALACKLFSGIFYMMMYCSVLLLVVISLDRFLLVTKPVWCQNNRQPRQARILCFIIWILGLLGSSPYFAHMEIQHHSETKTVCTGSYSSLGHAWAITIIRSFLFFLLPFLIICISHWKVYHMTSSGRRQRDKSSRTLRVILALVLGFFLCWTPLHIVDLLILVSDQPSERFEVNLNLAHVLTLCLAYINSCLNPLLYVCLGRGFKENLISSLRSVLHFASEAPTHGPSMTTNSKSTTDGVFREKPV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias324-339Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAAK04023738
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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