P0C7U5 · C5AR1_DANRE
- ProteinC5a anaphylatoxin chemotactic receptor 1
- Genec5ar1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids346 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | apical part of cell | |
Cellular Component | basolateral plasma membrane | |
Cellular Component | plasma membrane | |
Molecular Function | complement component C5a receptor activity | |
Molecular Function | complement receptor activity | |
Molecular Function | G protein-coupled receptor activity | |
Biological Process | chemotaxis | |
Biological Process | complement receptor mediated signaling pathway | |
Biological Process | inflammatory response | |
Biological Process | mRNA transcription by RNA polymerase II | |
Biological Process | phospholipase C-activating G protein-coupled receptor signaling pathway | |
Biological Process | positive regulation of cytosolic calcium ion concentration | |
Biological Process | positive regulation of epithelial cell proliferation | |
Biological Process | positive regulation of ERK1 and ERK2 cascade |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameC5a anaphylatoxin chemotactic receptor 1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionP0C7U5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-33 | Extracellular | ||||
Sequence: MDDNNSDWTSYDFGNDTIPSPNEISLSHIGTRH | ||||||
Transmembrane | 34-60 | Helical; Name=1 | ||||
Sequence: WITLVCYGIVFLLGVPGNALVVWVTGF | ||||||
Topological domain | 61-65 | Cytoplasmic | ||||
Sequence: RMPNS | ||||||
Transmembrane | 66-89 | Helical; Name=2 | ||||
Sequence: VNAQWFLNLAIADLLCCLSLPILM | ||||||
Topological domain | 90-106 | Extracellular | ||||
Sequence: VPLAQDQHWPFGALACK | ||||||
Transmembrane | 107-128 | Helical; Name=3 | ||||
Sequence: LFSGIFYMMMYCSVLLLVVISL | ||||||
Topological domain | 129-149 | Cytoplasmic | ||||
Sequence: DRFLLVTKPVWCQNNRQPRQA | ||||||
Transmembrane | 150-170 | Helical; Name=4 | ||||
Sequence: RILCFIIWILGLLGSSPYFAH | ||||||
Topological domain | 171-194 | Extracellular | ||||
Sequence: MEIQHHSETKTVCTGSYSSLGHAW | ||||||
Transmembrane | 195-220 | Helical; Name=5 | ||||
Sequence: AITIIRSFLFFLLPFLIICISHWKVY | ||||||
Topological domain | 221-238 | Cytoplasmic | ||||
Sequence: HMTSSGRRQRDKSSRTLR | ||||||
Transmembrane | 239-261 | Helical; Name=6 | ||||
Sequence: VILALVLGFFLCWTPLHIVDLLI | ||||||
Topological domain | 262-279 | Extracellular | ||||
Sequence: LVSDQPSERFEVNLNLAH | ||||||
Transmembrane | 280-300 | Helical; Name=7 | ||||
Sequence: VLTLCLAYINSCLNPLLYVCL | ||||||
Topological domain | 301-346 | Cytoplasmic | ||||
Sequence: GRGFKENLISSLRSVLHFASEAPTHGPSMTTNSKSTTDGVFREKPV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000343795 | 1-346 | C5a anaphylatoxin chemotactic receptor 1 | |||
Sequence: MDDNNSDWTSYDFGNDTIPSPNEISLSHIGTRHWITLVCYGIVFLLGVPGNALVVWVTGFRMPNSVNAQWFLNLAIADLLCCLSLPILMVPLAQDQHWPFGALACKLFSGIFYMMMYCSVLLLVVISLDRFLLVTKPVWCQNNRQPRQARILCFIIWILGLLGSSPYFAHMEIQHHSETKTVCTGSYSSLGHAWAITIIRSFLFFLLPFLIICISHWKVYHMTSSGRRQRDKSSRTLRVILALVLGFFLCWTPLHIVDLLILVSDQPSERFEVNLNLAHVLTLCLAYINSCLNPLLYVCLGRGFKENLISSLRSVLHFASEAPTHGPSMTTNSKSTTDGVFREKPV | ||||||
Glycosylation | 4 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 15 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 105↔183 | |||||
Sequence: CKLFSGIFYMMMYCSVLLLVVISLDRFLLVTKPVWCQNNRQPRQARILCFIIWILGLLGSSPYFAHMEIQHHSETKTVC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 323-346 | Disordered | ||||
Sequence: PTHGPSMTTNSKSTTDGVFREKPV | ||||||
Compositional bias | 324-339 | Polar residues | ||||
Sequence: THGPSMTTNSKSTTDG |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length346
- Mass (Da)39,115
- Last updated2008-07-22 v1
- Checksum832164A475DCA5AA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 324-339 | Polar residues | ||||
Sequence: THGPSMTTNSKSTTDG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CAAK04023738 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |