P0C783 · 2B_CMVFN

Function

function

Multifunctional protein that plays two independent roles: viral suppressor of host RNAi (VSR) and viral inducer of host attractiveness to insect vectors (VIA). Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (PubMed:25380036).
May directly interfere with mobile silencing signaling (By similarity).
Also inhibits signal transduction by the phytohormone jasmonate, making the infected plant more attractive to aphids, which are the second host to play a role as a dissemination vector. Acts by binding to and inhibiting JAZ degradation in the host (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleus
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Suppressor of silencing 2b
  • Alternative names
    • Protein 2b

Gene names

    • ORF names
      ORF2b

Organism names

Accessions

  • Primary accession
    P0C783

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis1-3Loss of cell-to-cell movement.
Mutagenesis10-12Loss of gene silencing suppressor function.
Mutagenesis22-24Loss of gene silencing suppressor function.
Mutagenesis31-33Loss of gene silencing suppressor function.
Mutagenesis34-36Loss of gene silencing suppressor function.
Mutagenesis40-42Loss of gene silencing suppressor function.
Mutagenesis55-57Loss of gene silencing suppressor function.
Mutagenesis70-72Loss of cell-to-cell movement.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003999101-110Suppressor of silencing 2b

Interaction

Subunit

Homotetramer (Probable). Interacts with host AGO1; this interaction blocks AGO1 cleavage activity to attenuate RNA silencing and thus counter host defense (PubMed:17158744).
Interacts with host JAZ (By similarity).

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, motif.

TypeIDPosition(s)Description
Region16-45Disordered
Motif22-27Nuclear localization signal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    110
  • Mass (Da)
    12,749
  • Last updated
    2010-11-02 v1
  • Checksum
    59690777E7D64128
MELNVGAMTNVELQLARMVEAKKQRRRSHKQNRRERGHKSPSERARSNLRLFRFLPFYQVDGSELTGSCRHVNVAELPESEASRLELSAEDHDFDDTDWFAGNEWAEGAF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D00355
EMBL· GenBank· DDBJ
-Genomic RNA No translation available.

Similar Proteins

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