P0C745 · HBZ_HTL1C
- ProteinHTLV-1 basic zipper factor
- GeneHBZ
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids209 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Enhances viral infectivity and persistence, and facilitates proliferation of HTLV-1-infected lymphocytes (PubMed:16424388).
Mechanistically, inhibits Tax-mediated viral replication and NF-kappa-B activation (PubMed:18599479, PubMed:21552325).
Plays a role in allowing infected T-cells to escape the cytotoxic T-lymphocyte response by maintaining low levels of viral protein production. Inhibits also host EP300 histone acetyltransferase (HAT) activity, reducing levels of acetylated histone H3 at 'Lys-18' (H3K18ac) in infected cells (PubMed:22434882).
Contributes to the accumulation of chromosomal abnormalities by inhibiting double-stranded DNA breaks (DSB) repair through the NHEJ pathway (PubMed:29769340).
Participates in the modulation of host immune response at multiple levels contributing to abnormal interferon signaling and viral pathogenesis (PubMed:28768861).
Mechanistically, inhibits Tax-mediated viral replication and NF-kappa-B activation (PubMed:18599479, PubMed:21552325).
Plays a role in allowing infected T-cells to escape the cytotoxic T-lymphocyte response by maintaining low levels of viral protein production. Inhibits also host EP300 histone acetyltransferase (HAT) activity, reducing levels of acetylated histone H3 at 'Lys-18' (H3K18ac) in infected cells (PubMed:22434882).
Contributes to the accumulation of chromosomal abnormalities by inhibiting double-stranded DNA breaks (DSB) repair through the NHEJ pathway (PubMed:29769340).
Participates in the modulation of host immune response at multiple levels contributing to abnormal interferon signaling and viral pathogenesis (PubMed:28768861).
Miscellaneous
Expressed from antisense transcripts. While mRNA expression levels of HBZ-SI were similar to those of HBZ, HBZ-SI seems slightly more expressed at the protein level ex vivo.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell nucleus | |
Molecular Function | DNA binding | |
Biological Process | symbiont-mediated suppression of host innate immune response | |
Biological Process | symbiont-mediated suppression of host NF-kappaB cascade | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHTLV-1 basic zipper factor
- Short namesHBZ
Gene names
Organism names
- Taxonomic lineageViruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Deltaretrovirus > Primate T-lymphotropic virus 1
- Virus hosts
Accessions
- Primary accessionP0C745
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000379888 | 1-209 | HTLV-1 basic zipper factor | |||
Sequence: MVNFVSVGLFRCLPVPCPEDLLVEELVDGLLSLEEELKDKEEEETVLDGLLSLEEESRGRLRRGPPGGKAPPRGETHRDRQRRAEEKRKRKKEREKEEEKQIAEYLKRKEEEKARRRKRAEEKAADFARRKQEEQERRERKWRQGAEKAKQHSARKEKMQELGVDGYTRQLEGEVESLEAERRRLLQEKEDLMGEVNYWQGRLEAMWLQ |
Post-translational modification
Ubiquitinated by host E3 ligase UBR5 leading to HBZ degradation.
Keywords
- PTM
Interaction
Subunit
Interacts with host ATF4; this interaction inhibits viral RNA transcriptional activation by preventing ATF4 binding to Tax-responsive elements. Interacts with host CREB1; this interaction inhibits host CREB1 transcriptional activity. Interacts with host JUN, JUNB and JUND (By similarity).
Interacts with host EP300 and CREBBP; these interactions inhibit the association of the coactivators with the viral promoter (PubMed:18599479, PubMed:22434882).
Interacts with host UBR5; this interaction regulates HBZ protein stability (PubMed:29441057).
Interacts with XRCC5 and XRCC6 (PubMed:29769340).
Interacts with IRF7 and IKBKE; this interaction modulates host interferon signaling (PubMed:28768861).
Interacts with host EP300 and CREBBP; these interactions inhibit the association of the coactivators with the viral promoter (PubMed:18599479, PubMed:22434882).
Interacts with host UBR5; this interaction regulates HBZ protein stability (PubMed:29441057).
Interacts with XRCC5 and XRCC6 (PubMed:29769340).
Interacts with IRF7 and IKBKE; this interaction modulates host interferon signaling (PubMed:28768861).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
XENO | P0C745 | THEMIS Q8N1K5 | 3 | EBI-16218595, EBI-2873538 |
Protein-protein interaction databases
Family & Domains
Features
Showing features for region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 41-165 | Disordered | ||||
Sequence: EEEETVLDGLLSLEEESRGRLRRGPPGGKAPPRGETHRDRQRRAEEKRKRKKEREKEEEKQIAEYLKRKEEEKARRRKRAEEKAADFARRKQEEQERRERKWRQGAEKAKQHSARKEKMQELGVD | ||||||
Compositional bias | 43-63 | Basic and acidic residues | ||||
Sequence: EETVLDGLLSLEEESRGRLRR | ||||||
Compositional bias | 72-163 | Basic and acidic residues | ||||
Sequence: PRGETHRDRQRRAEEKRKRKKEREKEEEKQIAEYLKRKEEEKARRRKRAEEKAADFARRKQEEQERRERKWRQGAEKAKQHSARKEKMQELG | ||||||
Motif | 87-92 | Nuclear localization signal 1 | ||||
Sequence: KRKRKK | ||||||
Motif | 116-120 | Nuclear localization signal 2 | ||||
Sequence: RRKRA | ||||||
Motif | 137-141 | Nuclear localization signal 3 | ||||
Sequence: RRERK |
Domain
Contains three nuclear localization signals NLS-1 and NLS-2, corresponding to two regions rich in basic amino acids, and NLS-3 corresponding to its DNA-binding domain.
Sequence similarities
Belongs to the HTLV-1 HBZ protein family.
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
P0C745-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameHBZ
- Length209
- Mass (Da)24,936
- Last updated2009-07-28 v1
- Checksum55323CF9189A7D54
P0C745-2
- NameHBZ-SI
- Differences from canonical
- 1-7: MVNFVSV → MAAS
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_037728 | 1-7 | in isoform HBZ-SI | |||
Sequence: MVNFVSV → MAAS | ||||||
Compositional bias | 43-63 | Basic and acidic residues | ||||
Sequence: EETVLDGLLSLEEESRGRLRR | ||||||
Compositional bias | 72-163 | Basic and acidic residues | ||||
Sequence: PRGETHRDRQRRAEEKRKRKKEREKEEEKQIAEYLKRKEEEKARRRKRAEEKAADFARRKQEEQERRERKWRQGAEKAKQHSARKEKMQELG |
Keywords
- Coding sequence diversity
- Technical term