P0C745 · HBZ_HTL1C

Function

function

Enhances viral infectivity and persistence, and facilitates proliferation of HTLV-1-infected lymphocytes (PubMed:16424388).
Mechanistically, inhibits Tax-mediated viral replication and NF-kappa-B activation (PubMed:18599479, PubMed:21552325).
Plays a role in allowing infected T-cells to escape the cytotoxic T-lymphocyte response by maintaining low levels of viral protein production. Inhibits also host EP300 histone acetyltransferase (HAT) activity, reducing levels of acetylated histone H3 at 'Lys-18' (H3K18ac) in infected cells (PubMed:22434882).
Contributes to the accumulation of chromosomal abnormalities by inhibiting double-stranded DNA breaks (DSB) repair through the NHEJ pathway (PubMed:29769340).
Participates in the modulation of host immune response at multiple levels contributing to abnormal interferon signaling and viral pathogenesis (PubMed:28768861).

Miscellaneous

Expressed from antisense transcripts. While mRNA expression levels of HBZ-SI were similar to those of HBZ, HBZ-SI seems slightly more expressed at the protein level ex vivo.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleus
Molecular FunctionDNA binding
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processsymbiont-mediated suppression of host NF-kappaB cascade
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    HTLV-1 basic zipper factor
  • Short names
    HBZ

Gene names

    • Name
      HBZ

Organism names

Accessions

  • Primary accession
    P0C745

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003798881-209HTLV-1 basic zipper factor

Post-translational modification

Ubiquitinated by host E3 ligase UBR5 leading to HBZ degradation.

Keywords

Interaction

Subunit

Interacts with host ATF4; this interaction inhibits viral RNA transcriptional activation by preventing ATF4 binding to Tax-responsive elements. Interacts with host CREB1; this interaction inhibits host CREB1 transcriptional activity. Interacts with host JUN, JUNB and JUND (By similarity).
Interacts with host EP300 and CREBBP; these interactions inhibit the association of the coactivators with the viral promoter (PubMed:18599479, PubMed:22434882).
Interacts with host UBR5; this interaction regulates HBZ protein stability (PubMed:29441057).
Interacts with XRCC5 and XRCC6 (PubMed:29769340).
Interacts with IRF7 and IKBKE; this interaction modulates host interferon signaling (PubMed:28768861).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
XENO P0C745THEMIS Q8N1K53EBI-16218595, EBI-2873538

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, motif.

TypeIDPosition(s)Description
Region41-165Disordered
Compositional bias43-63Basic and acidic residues
Compositional bias72-163Basic and acidic residues
Motif87-92Nuclear localization signal 1
Motif116-120Nuclear localization signal 2
Motif137-141Nuclear localization signal 3

Domain

Contains three nuclear localization signals NLS-1 and NLS-2, corresponding to two regions rich in basic amino acids, and NLS-3 corresponding to its DNA-binding domain.

Sequence similarities

Belongs to the HTLV-1 HBZ protein family.

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P0C745-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    HBZ
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    209
  • Mass (Da)
    24,936
  • Last updated
    2009-07-28 v1
  • Checksum
    55323CF9189A7D54
MVNFVSVGLFRCLPVPCPEDLLVEELVDGLLSLEEELKDKEEEETVLDGLLSLEEESRGRLRRGPPGGKAPPRGETHRDRQRRAEEKRKRKKEREKEEEKQIAEYLKRKEEEKARRRKRAEEKAADFARRKQEEQERRERKWRQGAEKAKQHSARKEKMQELGVDGYTRQLEGEVESLEAERRRLLQEKEDLMGEVNYWQGRLEAMWLQ

P0C745-2

  • Name
    HBZ-SI
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-7: MVNFVSV → MAAS

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0377281-7in isoform HBZ-SI
Compositional bias43-63Basic and acidic residues
Compositional bias72-163Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D13784
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AF033817
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Similar Proteins

Disclaimer

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