Nonstructural protein 1 (nsp1) is a characteristic feature of alpha- and betacoronaviruses which exhibits both functional conservation and mechanistic diversity in inhibiting host gene expression and antiviral responses.
study demonstrates that overexpression of Porcine deltacoronavirus (PDCoV) nsp5 also antagonizes IFN signaling by cleaving STAT2 an essential component of transcription factor complex ISGF3 and that PDCoV infection reduces the levels of STAT2 which may affect the innate immune response
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