P0C6V8 · R1AB_BRV1
- ProteinReplicase polyprotein 1ab
- Generep
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids6733 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
3C-like serine proteinase
The 3C-like serine proteinase is responsible for the majority of cleavages.
Helicase
The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity.
Exoribonuclease
Acts on both ssRNA and dsRNA in a 3' to 5' direction.
Uridylate-specific endoribonuclease
NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.
Catalytic activity
RNA-directed RNA polymerase
RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
Features
Showing features for site, active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 2753-2754 | Cleavage; by 3C-like serine proteinase | ||||
Sequence: QS | ||||||
Site | 3131-3132 | Cleavage; by 3C-like serine proteinase | ||||
Sequence: QS | ||||||
Active site | 3184 | Charge relay system; for 3C-like serine proteinase activity | ||||
Sequence: H | ||||||
Active site | 3222 | Charge relay system; for 3C-like serine proteinase activity | ||||
Sequence: E | ||||||
Active site | 3291 | Charge relay system; for 3C-like serine proteinase activity | ||||
Sequence: S | ||||||
Site | 3418-3419 | Cleavage; by 3C-like serine proteinase | ||||
Sequence: QS | ||||||
Site | 3677-3678 | Cleavage; by 3C-like serine proteinase | ||||
Sequence: QA | ||||||
Site | 3854-3855 | Cleavage; by 3C-like serine proteinase | ||||
Sequence: QS | ||||||
Site | 4036-4037 | Cleavage; by 3C-like serine proteinase | ||||
Sequence: QA | ||||||
Site | 4121-4122 | Cleavage; by 3C-like serine proteinase | ||||
Sequence: QG | ||||||
Site | 4274-4275 | Cleavage; by 3C-like serine proteinase | ||||
Sequence: QS | ||||||
Site | 5286-5287 | Cleavage; by 3C-like serine proteinase | ||||
Sequence: QA | ||||||
Binding site | 5293 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 5296 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 5304 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 5307 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 5314 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 5317 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 5321 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 5327 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 5336 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 5338 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 5359 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 5362 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Site | 5844-5845 | Cleavage; by 3C-like serine proteinase | ||||
Sequence: QS | ||||||
Active site | 5860 | |||||
Sequence: D | ||||||
Active site | 5862 | |||||
Sequence: E | ||||||
Active site | 5961 | |||||
Sequence: D | ||||||
Binding site | 6025 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 6029 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 6033 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 6037 | |||||
Sequence: H | ||||||
Active site | 6042 | |||||
Sequence: D | ||||||
Binding site | 6048 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Site | 6174-6175 | Cleavage; by 3C-like serine proteinase | ||||
Sequence: VE | ||||||
Site | 6318-6319 | Cleavage; by 3C-like serine proteinase | ||||
Sequence: LG | ||||||
Active site | 6363 | |||||
Sequence: H | ||||||
Active site | 6380 | |||||
Sequence: H | ||||||
Active site | 6412 | |||||
Sequence: K | ||||||
Site | 6468-6469 | Cleavage; by 3C-like serine proteinase | ||||
Sequence: QK | ||||||
Active site | 6509 | |||||
Sequence: K | ||||||
Active site | 6585 | |||||
Sequence: D | ||||||
Active site | 6613 | |||||
Sequence: K | ||||||
Active site | 6647 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell membrane | |
Cellular Component | membrane | |
Molecular Function | 3'-5'-RNA exonuclease activity | |
Molecular Function | 5'-3' DNA helicase activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | cysteine-type peptidase activity | |
Molecular Function | endonuclease activity | |
Molecular Function | mRNA (nucleoside-2'-O-)-methyltransferase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Molecular Function | serine-type peptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | DNA-templated transcription | |
Biological Process | methylation | |
Biological Process | proteolysis | |
Biological Process | viral RNA genome replication | |
Biological Process | viral translational frameshifting |
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameReplicase polyprotein 1ab
- Short namespp1ab
- Alternative names
- Cleaved into 14 chains
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Tornidovirineae > Tobaniviridae > Torovirinae > Torovirus > Renitovirus > Bovine torovirus
- Virus hosts
Accessions
- Primary accessionP0C6V8
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Putative papain-like proteinase
Host membrane ; Multi-pass membrane protein
Non-structural protein 2
Host membrane ; Multi-pass membrane protein
Non-structural protein 4
Host membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 2191-2211 | Helical | ||||
Sequence: IVVYLMVLWFVLLYCFSDFSL | ||||||
Transmembrane | 2219-2239 | Helical | ||||
Sequence: VFLLWLSHVVLVVKKLDLGLV | ||||||
Transmembrane | 2266-2286 | Helical | ||||
Sequence: GVHWLILKLLFYSFHFYDFFV | ||||||
Transmembrane | 2411-2431 | Helical | ||||
Sequence: ALWFYVVFYSGFVSFWLPLMF | ||||||
Transmembrane | 2521-2541 | Helical | ||||
Sequence: VAVSSLGFINPLMWPLFIVVL | ||||||
Transmembrane | 2546-2566 | Helical | ||||
Sequence: FVWFFNVLSYIMLPVFVIILF | ||||||
Transmembrane | 2769-2789 | Helical | ||||
Sequence: VMLIIALGAIFVFMYSCFMVG | ||||||
Transmembrane | 2937-2957 | Helical | ||||
Sequence: IISPYVFVVLVAIFTIVFLFL | ||||||
Transmembrane | 2986-3006 | Helical | ||||
Sequence: VLFVVCLPPLVPGVVFVLALW | ||||||
Transmembrane | 3022-3042 | Helical | ||||
Sequence: LFILPWFYVMLFVLIVGGFVF | ||||||
Transmembrane | 3422-3442 | Helical | ||||
Sequence: SNVSWVVENLHFIFSVYFLVC | ||||||
Transmembrane | 3456-3478 | Helical | ||||
Sequence: VVLPLFFVVQLLSTVVLKNVLFW | ||||||
Transmembrane | 3486-3506 | Helical | ||||
Sequence: LAVTFYVHSEVAESMYLLGLF | ||||||
Transmembrane | 3514-3534 | Helical | ||||
Sequence: VGLILVVSVMCLFVVVRVVVN | ||||||
Transmembrane | 3538-3558 | Helical | ||||
Sequence: AIFVVVVSVLLIVVNVVLGVV | ||||||
Transmembrane | 3573-3593 | Helical | ||||
Sequence: AVFAALLTPQPVVAIMMLILF | ||||||
Transmembrane | 3598-3613 | Helical | ||||
Sequence: LMSFAFVVIVLSFRVF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000283859 | 1-2753 | Putative papain-like proteinase | |||
Sequence: MSKTSRELTNETELHLCSSTLDLISKSQLLAQCLGTPQNLVSLSKMVPSILESPTLEPRYTSTHSSSLQSLQLLALNTSSTLYKWTTGSISKLRGHLERELCRGLVPLNDFIPKGNYVELSLMIPSVLTGQGTSTTTTLQEMCSDMVQSCIKSMETDLLKGVLALKDQTSCQEYFLSANYQSLIPPQPLVNAMRMSSVVDLSPLILENTRLLLKLSPFHGGTSVSYTSMIREFVDCSRRDEKCLKRRLTKKQKRQEEGSFDANKVITLGGKMYRYRVVILKCSDEVDDLIGFDGKVGEFDYNFENVPHCWRDLVKRRCLIRAKATWNLAGGVDENLDHVYIDESQXDFRCADGSSDSPSACVEDPHLEERIFSRVWLKQTSRFFGTKIQQVSELFKSIGLPELETTYCGVNPVKVGNKWLSFRDQGRSRVFFVYTDSNVYLATTRQKVCCDYILTKFKSVKWIGNKPDQCRVVKVLAWLISVNKVKNCTRVITPMLTVQGKISHRRVDYLDISVLDSYVSDTAGLNCVQKVKKFLSMYYNCGADLGLLDNFLTPIECGTKQLVFERCNCPNHQFYVAQFDNHVVLGLGRPTGVVYPEEIPSCANIYAVGFATQKRVVEVHYYSEMDRHQLPQDYYYFAYDQEFQHVGGDDYVNHHLDDVEDQPFPPVLFDDVYDSGDSLDDGGSDLDCFDVGYDFFWPEAPIPVPSPYGYYQGQRLRDLCVAGGDFGCDCPRCDGTFIYHPFRPRHYHSFDEVGPFIQMCEFTLTYSGQNYNLFYGLEPKVCLQDLVEASDKLLQLLVRGQLENISLPNDILACLSSLKLGANIHPFLWPAPFFNANGEWVDIFGGGDFTVFGEDFCLKAKSMVESVYFLVENFFSVDCPIGNLYCNLHLDGDVKKMLWSTIHMKYIYLALIHSEKVFNIILNSRQLSHQELVKLVIIGTFDVSIVAPCACSGDCNHGKVYNWTNLLSSVYRFVTLDQLVGLSYCEKRSLVLRKVQQYLEVEEGYQRPVQLLMAPFYGFNDNAEPDEQPLTGVFHQQVMQMFDTCVMLDVICGLKRPRASVYNLFGVLADYFRRPFTFRYYQVAEFSGSESTQVFTDVTSALTSKDPCSNRPYIYHDYAVCRVVEPRTAAVTTRGAIYPPEVIEMIRSYLPIEFDVGVMNYVDGNCDFKYCNLEFCLSGRGLVKLDTGELLDYKTNLFVVRYKTLPLLYVTSNPIYLSDFSLDNAVCLTGDFKLSFDVEPGSTLFGLYFTNGRCYRDVWETLPRFGLGTLSPPKCHSKCEPFENLAEVFFFKRRVQLVPLVNNYTPVFRHRPDIPKVLTVELMPYYSSIGYQGFVAPKCVLPGCVATQYCKLRHQLDRCVQVTKLAVAYAFYFKPLNIGSLYHLDPMRGTSYGKPAVVQFEPVGLIKEVNILVYQFGKHVAIHYFPECPTYVAYGHYPSHSVGVWLGYLPSVEECVIAQRNYRVYVPTCFRLSRTGCYHIQQDEDFERTHITVSYHYARDFDTKSLTPMFQMFSKIFGKSKQDLICALNSLSEESQSVLTLFCEEFDSAYTLQTISDEVSFETSTSPELVACVLAYAIGYELCLTVKTDGECESLDVGSSLEQVYVDYDVSKNVWDLSTHLQDDSSDDLELPFNQYYEFKVGRASVVLVQDDFKSVYDFLKSEQGVDYVVNPANNQLKHGGGIAKVISCMCGPKLTSWSNNYIKQYKKLGVTCAIRSPGFQLGKGVQIIHVVGPKSADSDVVNKLEASWRSVFQNVKPDTTVLTSMLSTGIFGCSVTDSATTLLSNLVDLDKDVVVFVVTNVSDQYIEALGVVESFQSAHGLPNFGNTCWFNALYQLLKSFAVKEQIVQDLVNCFDDFYECPTRQCVEWVCDQLGVVFGEQYDAVEMLVKIFDVFKCNVRVGYDCLARLQQVALGSCREVPADAVLMFFGQDKSGHWVAARKVCGVWYTFDDKVVVKKDPDWSKVVLVLRERGLFKATDFETPRPRRRRVAYRVPRDTISQDAIMFLEERQFSSGTMLAHSCVESVESFHVEGVQPSPLQSVDGLDDVADLSCDNHVCDNSDLQEPQVVVSQPSEVLTTSMSIECPVLENSECSVETDLNPVCEENEQVGESGIKEQDGVTTSDSQQVFSKSLDPIIKQHEVESVEPQDLPVFSQQPQVMLSMTWRDVLFQQYLGFKSDLLSLTHVNKFKIVVYLMVLWFVLLYCFSDFSLLSRFCLYVFLLWLSHVVLVVKKLDLGLVNSGGESYVLRILSSVKVPNCIAFNCDGVHWLILKLLFYSFHFYDFFVKTLVVVFQMPQLRCFTWPLLKLGFADTFLSHHILAFPTKQVSQSCLPVFGDERKYIYVPYWCKESFRTLVARAKQLTATGRTKTLDNWHYQCCSKTVKPSSCFNVRDFVFDDACNNHKHYGFFSALWFYVVFYSGFVSFWLPLMFCYCALFMCTFKNLPVNITRPIRWTVLQQVVDDLLSIITKPLFGRPACPPLSAYLTATTADEAVRASRSLLGRFCTPVGFQQPIMNVENGVAVSSLGFINPLMWPLFIVVLLDNRFVWFFNVLSYIMLPVFVIILFYFYLRKICGCVNVKGVVKNCTRHFQNFSKPLVAAGVHGNRTNFTYQPMQENWCDRHSWYCPKEEHYMTPEMAMFIKNYYNLATSPMADTIWCDYVKSVPNMTWANFKFSLFKSNETVMCGPSSHADSMLLSWYAFLHGIRFAVNPSVIDIPSQTQPIYVSSDSDDSLDKGCDVSLRPTKNKGKFKKQ | ||||||
Chain | PRO_0000283860 | 2754-3131 | Non-structural protein 2 | |||
Sequence: SVAYFSAGPVDLWYYVMLIIALGAIFVFMYSCFMVGQYVVMPRDKFFGVNPTGYSYVNAQPYLHASPPVLRNSDGMVLATPLKVPSISYSVYRLLSGHLYFTKLIVAENECTPPFGAXRLSHEFTCNDFTYILPAHLRIFGRYIMLIHPDQLHMLPFEVEHSTHTRLCYVTGTNIVECLPTFEIISPYVFVVLVAIFTIVFLFLLRMYIVMYSYFKVFTYVVFKLLFVNTVMVLFVVCLPPLVPGVVFVLALWLCDSVVFLLYLAVLSLFILPWFYVMLFVLIVGGFVFWWMMKSSDVVHLTPDGLTFNGTFEQVSKCVFPLNPLIVNRLLLDCRMSHSDLVEKSKLKTTEGKLATEMMKVFMTGETAYYQPSNFSFQ | ||||||
Chain | PRO_0000283862 | 3132-3418 | 3C-like serine proteinase | |||
Sequence: SVFSKVVSPFTLHARPPMPMFRLYVYFNGQCVGTTCTGTGFAIDDSTIVTAKHLFECDDLKPTHLSVELSCRSYWCTWKEPNVLSWKFEGENAYISVENLRDFYGIDFKYLPFQQIECEFYKRMEAVTIYSIKYGSEFATQAWQTVNGHFVCCNTEGGDSGAPLVWRDSVIGVHQGLCDSFKTTLASDSKGVMMTEVKGYHVDPPVYYKPIIMSAAYNKFVADSDVSVGECTNYHNFVNEDFFSMHDELEKVSFGDKMFRYCQSLPRYLEPLHYFHVPSFWQPFKKQ | ||||||
Chain | PRO_0000283863 | 3419-3677 | Non-structural protein 4 | |||
Sequence: SVSSNVSWVVENLHFIFSVYFLVCDFVAYWWLDDPFSVVLPLFFVVQLLSTVVLKNVLFWNTSYLVTLAVTFYVHSEVAESMYLLGLFSDQIVNRVGLILVVSVMCLFVVVRVVVNVKRAIFVVVVSVLLIVVNVVLGVVQFNSLVAVCMFDIYAVFAALLTPQPVVAIMMLILFDTKCLMSFAFVVIVLSFRVFKNYKFVRVLHNLCNFDFVLTQLSLFRYRHHNQGNNPSHYEALWLFLKELYYGVQDVKYEVFSPQ | ||||||
Chain | PRO_0000283864 | 3678-3854 | Non-structural protein 5 | |||
Sequence: AGTYNVRFLTDMTEQDQLEAVEQVQRRLQRFSIVQDKNSQRLVLYSKNVDFLRSQIQHQRVLGANPFIITTLTPKDIAIDNVEVHNPSQFKPEDLQAHMWFYSKSPIFVGQVPIPTNVQTAAVLDTTYNCQDLTADEKNNVAANLQIQNAALTLSLFEECNRFLESELGDVPTLMWQ | ||||||
Chain | PRO_0000283865 | 3855-4036 | Non-structural protein 6 | |||
Sequence: SEDVVDVKQLEVQIEKLRVVLDGMQLGTSEYKATRKQINILQSQLDKALAFERKLAKFLEKVDQQQAITNETAKQLSAFKNLVKQVYESYMSSLKVRVVESNDASCLLTSTDLPRKLVLMRPITGLDNIKIVEKANGCEITAFGDTFTTGLGSNLAGLAYSSTQPLSAYPFIFNLEGIFKQQ | ||||||
Chain | PRO_0000283866 | 4037-4121 | Non-structural protein 7 | |||
Sequence: ANIGYKTVECNMSSDNGSVLYKGKIVAVPSEDNPDFVVCGKGYKLDCGINVLMIPSIVRYITLNLTDHLQRQSLKPRRRLQYKQQ | ||||||
Chain | PRO_0000283867 | 4122-4274 | Non-structural protein 8 | |||
Sequence: GVRLGGVNLGEHQAFSNELISSVGYTTWVSSTVCTDKSHKHPWFVQIPSSEKDPEWFMHNTQVKNNQWVVDAKPTHWLVDADTNEQLFALALTDEEYLKAESILAKWSPITQDVECWFKDLRGYYTVSGLQPLWPVCPKKICSLKIVPIFQSQ | ||||||
Chain | PRO_0000283868 | 4275-5286 | RNA-directed RNA polymerase | |||
Sequence: SVAYADEPTHFLSLPVVNKNFLEAFYELQEGFPGEKQVAPHISLTMLKLTEEDVAKVEDILDEMVLPNTYATITNPHMMGQYYVFEVEGLQALHDEVVSVLRQHGIACDQTRMWKPHLTIGEIKDGSVFNKFKDFGITCKLEDCDFVKLGAPKANARYEFIATLPVGDFKLLRDVWCACRHLCFQNGAYQSSRSKHYIDLATEYNAGIVKVNKSNTHSVEYKGQRFMIKRVKDQHEFALARTAFLPSIIPHHMVHQNGEWFLVRGPTTQWSLGDLVYAIWLGDQAYLDECGFVFNPSRDEFLDDANQRSYLANLLEPAILSFCEIFHCVKGCQVPYKITLDNLDLKGQLYDFGDYPCPNKVDNQSALFVLAEVWSMTRKPFPTKFAQVLAKEMNVPADFQMYFQHTLLSGKYFDKAMCLNNVRPLLRDPANLTTTPFFSQHSGVWTHFYNPIYGLVECDLEEFSNLPEVLQQLITVQGPITSAMTPAISIGEGVYAANVPPVAAAKQKIPLYDVGLCQELTDAGVDCGEAFKYFYYLSNPAGALADVCFYDYQGTGFYSPKLLAGVYDFMKRVTTCYKTDERFTYEQAKPRKSSMGINITGYQQDAVYRALGPENITKLFEYAQKAPLPFCTKIITKFALSAKARARTVSSCSFIASTIFRFAHKPVTSKMVEVAQNSQGFCLIGVSKYGLKFSKFLKDKYGAIEQFDVFGSDYTKCDRTFPLSFRALTAALLYELGGWEEDSWLYLNEVNSYMLDTMLCDGMLLNKPGGTSSGDATTAHSNTFYNYMVHYVVAFKTILSDLSDCNKVMRIAAHNAYTTGDYGVFNTLLEEQFQTNYFLNFLSDDSFIFSKPGALKIFTCENFSNKLQTILHTKVDLTKSWATTGHIEEFCSAHIIKTDGEYHFLPSRGRLLASLLILDKLSDVDIYYMRFVAILCESAVYSRYQPEFFNGLFQVFLDKVQQFRKDYCCDPCPTQLLDRQFYENLVFTSNTEVGLVDCYLENFKLQCEFKQQ | ||||||
Chain | PRO_0000283869 | 5287-5844 | Helicase | |||
Sequence: AGFDRVCFCCPNPAVSVCEECYVPLPLCAYCYYVHVVISSHCKIEDKFKCPCGQDDIRELFIVLNNSICIYQCRSCVESDRLRISLLSDVDQVVRLPGFKANSASIAKNGVAQLLTPVDNVDVSLDWNHQETVQQNVARIVYHSANMTQMSIEVVYVNFSLVRNDGSSAILDIPNFKCPDTSYCLFYKPGKTGVLKFTGKGTLTSCYDSNNLTWFKVTCPDFNQPWRLATCFVIQQHDAVYPPIKSTQYENVTFVMGPPGTGKTTFVYNTYLSKASPSNRFVYCAPTHRLVGDMDEKVDGAVVVSAYNDRTYRNPVWKKDDSYDVLLCTHNTLPFIKSAVLIVDEVSLIPPHVMIKILSMGFKKVVLLGDPFQLSPVYKNHKVHFKYDTFYLLQLATQKRYLTACYRCPPQILSAFSKPYCDVGVDLVSFNNKPGKFDIIVSKQLANMQDFSVLSVLSKEYPGYVILVNYRAAVDYAMQNGLGDVTTIDSSQGTTAANHLLVLFGASNFSKTINRVIVGCSRSTTHLVVVCCPELYKHFQPILNWPEPVYRYFGMEKQ | ||||||
Chain | PRO_0000283870 | 5845-6174 | Exoribonuclease | |||
Sequence: SDFNIIPEVASLVFCDIEFWHYKADPNSKTRTVYPGQIAVVTSQTLQLYLGVFDDAGYKSALRGLPKDVFVPPNWVWMRKHYPSFEQHAYNMQRLFKFIIDTTCGQPWFILYSCSNDLKSLKFYVEFGTNYFCSCGELAICLMRDGLYKCRNCYGNMSISKLVNCKYLDVQKERIKLQDAHDAICQQFHGDSHEALCDAVMTKCLYLASYDAAFKDTIHVKYKDLCLEIQYKITSPYVRYDGVNKRYLYRDHGAMHYFKTPKSPMQNVYRYEVGAHTEYSINICNSYEGCQSFGKTCTKCIHIHCIVEQFMADDRYRDFILVSVVKSDFV | ||||||
Chain | PRO_0000283871 | 6175-6318 | Non-structural protein 13 | |||
Sequence: EQALSPAAKALMLTVTRVEGKSFYTSNGQRYDLYDYDLSKSVMRVVGASVKPLPLYSVVVGLGINCTVGCVLPNVPMKLKDELLSTDVPLSTLRLDLPTWYYVTWPTLSNRTSRWKLAGAQVYDCSVHIYVEATGEQPLYYLQL | ||||||
Chain | PRO_0000283872 | 6319-6468 | Uridylate-specific endoribonuclease | |||
Sequence: GNGESLRELPETLFSTGRLYNLEHDPSKNFNVQQLAIETIPKNHHVFAGDFTDVGTDIGGVHHVVALNGYKGSIIPNYVKPIATGLINVGRSVKRTTLVDVCANQLYEKVKQQIAGVKVSKVIFVNIDFQEVQFMVFAKGEDDIQTFYPQ | ||||||
Chain | PRO_0000283873 | 6469-6733 | Putative 2'-O-methyl transferase | |||
Sequence: KEFIRSYYEWPTILPELESHYDLKNYGQDPQFMPQPVNFAKYTQICTFIQEHVKVARNSLIWHVGAAGIDGCSPGDIVLSSFFKECLVYSWDVKDYDTLLEKHNYDCNFRPNLIVSDVYNVSSNVSEVLEDCVHRLALGGTIIFKTTESSRPDIQLSKVTKYFAAVHFFTAGVNTSSSEVFVVLKYKLHSEPIGEELCSPNILRRIAAYRNKLCIVPNFKVFSTSLSYRFSSVKFVQKCFYVSVPRQFCASGLIQEVPLLCQMKH |
Post-translational modification
Isoform Replicase polyprotein 1ab
Specific enzymatic cleavages in vivo by its own protease yield mature proteins. 3CL-PRO is autocatalytically processed.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1633-1814 | Macro | ||||
Sequence: FNQYYEFKVGRASVVLVQDDFKSVYDFLKSEQGVDYVVNPANNQLKHGGGIAKVISCMCGPKLTSWSNNYIKQYKKLGVTCAIRSPGFQLGKGVQIIHVVGPKSADSDVVNKLEASWRSVFQNVKPDTTVLTSMLSTGIFGCSVTDSATTLLSNLVDLDKDVVVFVVTNVSDQYIEALGVVE | ||||||
Region | 2183-2565 | HD1 | ||||
Sequence: LTHVNKFKIVVYLMVLWFVLLYCFSDFSLLSRFCLYVFLLWLSHVVLVVKKLDLGLVNSGGESYVLRILSSVKVPNCIAFNCDGVHWLILKLLFYSFHFYDFFVKTLVVVFQMPQLRCFTWPLLKLGFADTFLSHHILAFPTKQVSQSCLPVFGDERKYIYVPYWCKESFRTLVARAKQLTATGRTKTLDNWHYQCCSKTVKPSSCFNVRDFVFDDACNNHKHYGFFSALWFYVVFYSGFVSFWLPLMFCYCALFMCTFKNLPVNITRPIRWTVLQQVVDDLLSIITKPLFGRPACPPLSAYLTATTADEAVRASRSLLGRFCTPVGFQQPIMNVENGVAVSSLGFINPLMWPLFIVVLLDNRFVWFFNVLSYIMLPVFVIIL | ||||||
Region | 2769-3042 | HD2 | ||||
Sequence: VMLIIALGAIFVFMYSCFMVGQYVVMPRDKFFGVNPTGYSYVNAQPYLHASPPVLRNSDGMVLATPLKVPSISYSVYRLLSGHLYFTKLIVAENECTPPFGAXRLSHEFTCNDFTYILPAHLRIFGRYIMLIHPDQLHMLPFEVEHSTHTRLCYVTGTNIVECLPTFEIISPYVFVVLVAIFTIVFLFLLRMYIVMYSYFKVFTYVVFKLLFVNTVMVLFVVCLPPLVPGVVFVLALWLCDSVVFLLYLAVLSLFILPWFYVMLFVLIVGGFVF | ||||||
Region | 3430-3613 | HD3 | ||||
Sequence: NLHFIFSVYFLVCDFVAYWWLDDPFSVVLPLFFVVQLLSTVVLKNVLFWNTSYLVTLAVTFYVHSEVAESMYLLGLFSDQIVNRVGLILVVSVMCLFVVVRVVVNVKRAIFVVVVSVLLIVVNVVLGVVQFNSLVAVCMFDIYAVFAALLTPQPVVAIMMLILFDTKCLMSFAFVVIVLSFRVF | ||||||
Domain | 4442-4673 | NiRAN | ||||
Sequence: DFKLLRDVWCACRHLCFQNGAYQSSRSKHYIDLATEYNAGIVKVNKSNTHSVEYKGQRFMIKRVKDQHEFALARTAFLPSIIPHHMVHQNGEWFLVRGPTTQWSLGDLVYAIWLGDQAYLDECGFVFNPSRDEFLDDANQRSYLANLLEPAILSFCEIFHCVKGCQVPYKITLDNLDLKGQLYDFGDYPCPNKVDNQSALFVLAEVWSMTRKPFPTKFAQVLAKEMNVPADF | ||||||
Domain | 4981-5132 | RdRp catalytic | ||||
Sequence: FDVFGSDYTKCDRTFPLSFRALTAALLYELGGWEEDSWLYLNEVNSYMLDTMLCDGMLLNKPGGTSSGDATTAHSNTFYNYMVHYVVAFKTILSDLSDCNKVMRIAAHNAYTTGDYGVFNTLLEEQFQTNYFLNFLSDDSFIFSKPGALKIF | ||||||
Domain | 5289-5404 | CV ZBD | ||||
Sequence: FDRVCFCCPNPAVSVCEECYVPLPLCAYCYYVHVVISSHCKIEDKFKCPCGQDDIRELFIVLNNSICIYQCRSCVESDRLRISLLSDVDQVVRLPGFKANSASIAKNGVAQLLTPV | ||||||
Domain | 5509-5688 | +RNA virus helicase ATP-binding | ||||
Sequence: NQPWRLATCFVIQQHDAVYPPIKSTQYENVTFVMGPPGTGKTTFVYNTYLSKASPSNRFVYCAPTHRLVGDMDEKVDGAVVVSAYNDRTYRNPVWKKDDSYDVLLCTHNTLPFIKSAVLIVDEVSLIPPHVMIKILSMGFKKVVLLGDPFQLSPVYKNHKVHFKYDTFYLLQLATQKRYL | ||||||
Domain | 5689-5848 | +RNA virus helicase C-terminal | ||||
Sequence: TACYRCPPQILSAFSKPYCDVGVDLVSFNNKPGKFDIIVSKQLANMQDFSVLSVLSKEYPGYVILVNYRAAVDYAMQNGLGDVTTIDSSQGTTAANHLLVLFGASNFSKTINRVIVGCSRSTTHLVVVCCPELYKHFQPILNWPEPVYRYFGMEKQSDFN | ||||||
Domain | 5846-6059 | ExoN | ||||
Sequence: DFNIIPEVASLVFCDIEFWHYKADPNSKTRTVYPGQIAVVTSQTLQLYLGVFDDAGYKSALRGLPKDVFVPPNWVWMRKHYPSFEQHAYNMQRLFKFIIDTTCGQPWFILYSCSNDLKSLKFYVEFGTNYFCSCGELAICLMRDGLYKCRNCYGNMSISKLVNCKYLDVQKERIKLQDAHDAICQQFHGDSHEALCDAVMTKCLYLASYDAAFK | ||||||
Domain | 6327-6467 | NendoU | ||||
Sequence: LPETLFSTGRLYNLEHDPSKNFNVQQLAIETIPKNHHVFAGDFTDVGTDIGGVHHVVALNGYKGSIIPNYVKPIATGLINVGRSVKRTTLVDVCANQLYEKVKQQIAGVKVSKVIFVNIDFQEVQFMVFAKGEDDIQTFYP | ||||||
Domain | 6469-6733 | Nidovirus-type SAM-dependent 2'-O-MTase | ||||
Sequence: KEFIRSYYEWPTILPELESHYDLKNYGQDPQFMPQPVNFAKYTQICTFIQEHVKVARNSLIWHVGAAGIDGCSPGDIVLSSFFKECLVYSWDVKDYDTLLEKHNYDCNFRPNLIVSDVYNVSSNVSEVLEDCVHRLALGGTIIFKTTESSRPDIQLSKVTKYFAAVHFFTAGVNTSSSEVFVVLKYKLHSEPIGEELCSPNILRRIAAYRNKLCIVPNFKVFSTSLSYRFSSVKFVQKCFYVSVPRQFCASGLIQEVPLLCQMKH |
Domain
The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.
Keywords
- Domain
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Ribosomal frameshifting.
P0C6V8-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameReplicase polyprotein 1ab
- Synonymspp1ab
- NoteProduced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
- Length6,733
- Mass (Da)765,975
- Last updated2008-06-10 v1
- Checksum7947CE8F5F1FA90D
P0C6F4-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameReplicase polyprotein 1a
- Synonymspp1a, ORF1a polyprotein
- NoteProduced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Keywords
- Coding sequence diversity
- Technical term