P0C6L4 · LHDAG_HDV83

Function

function

Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication (By similarity).

Miscellaneous

This strain belongs to the genotype II found only in East Asia.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell
Cellular Componenthost cell nucleolus
Cellular Componentvirion component
Molecular FunctionRNA binding
Biological Processsymbiont entry into host cell
Biological Processviral penetration into host nucleus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Large delta antigen
  • Short names
    L-HDAg
  • Alternative names
    • p27

Organism names

Accessions

  • Primary accession
    P0C6L4

Proteomes

Subcellular Location

Note: isoprenylated in the cytoplasm, and translocates in the nucleus possibly after phosphorylation. Translocates after to nuclear speckle, then to the ER membrane where interaction with Hepatitis B virus antigene takes place (By similarity).

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, lipidation, propeptide.

TypeIDPosition(s)Description
ChainPRO_00000381261-211Large delta antigen
Modified residue2Phosphoserine; by host
Modified residue14Omega-N-methylated arginine; by host
Modified residue72N6-acetyllysine; by host
Modified residue123Phosphoserine; by host
Modified residue177Phosphoserine; by host
Modified residue211Cysteine methyl ester; by host
Lipidation211S-farnesyl cysteine; by host
PropeptidePRO_0000396793212-214Removed in mature form

Post-translational modification

Prenylated by host farnesyl-transferase in the cytoplasm prior to nucleus translocation.
Phosphorylated at serines by host CK2 and other kinases. phosphorylation does not seem to be important for its function (By similarity).

Keywords

Interaction

Subunit

Homodimer. Homooctamer. Interacts with HBV HBsAg. May interact with clathrin to induce virion budding (By similarity).

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain, compositional bias, motif.

TypeIDPosition(s)Description
Region13-60Dimerization
Domain21-195HDAg
Region58-214Disordered
Compositional bias65-147Basic and acidic residues
Motif66-75Nuclear localization signal
Region97-107RNA-binding
Region130-195RNAPII-binding
Region136-146RNA-binding

Sequence similarities

Belongs to the hepatitis delta antigen family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    214
  • Mass (Da)
    24,086
  • Last updated
    2009-04-14 v1
  • Checksum
    2562DEA7E2243FBD
MSQSETRRGRRGTREETLEKWITARKKAEELEKDLRKTRKTIKKLEEENPWLGNIVGIIRKGKDGEGAPPAKRPRTDQMEVDSGPGKRPHKSGFTDKEREDHRRRKALENKKKQLSAGGKILSKEEEEELRRLTDEDEERKRRVAGPRVGDVNPSRGGPRGAPGGGFVPQMAGVPESPFSRTGEGLDIRGTQGFPWVSPSPPQQRLPLLECTPQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias65-147Basic and acidic residues

RNA Editing

Edited at position 196
Partially edited. RNA editing at this position occurs on the antigenomic strand and consists of a conversion of A to G catalyzed by the cellular enzyme ADAR1. The unedited RNA version gives rise to the small delta antigen (AC P69618), which ends with a nonsense codon at position 196. In the edited version, this amber codon is modified to a tryptophan codon and gives rise to the large delta antigen protein. S-HDAg suppresses editing of non-replicating antigenomic RNA, thereby regulating the extent of editing (By similarity)

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X60193
EMBL· GenBank· DDBJ
CAA42749.1
EMBL· GenBank· DDBJ
Genomic RNA Different termination.

Similar Proteins

Disclaimer

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