P0C6L4 · LHDAG_HDV83
- ProteinLarge delta antigen
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids214 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication (By similarity).
Miscellaneous
This strain belongs to the genotype II found only in East Asia.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell | |
Cellular Component | host cell nucleolus | |
Cellular Component | virion component | |
Molecular Function | RNA binding | |
Biological Process | symbiont entry into host cell | |
Biological Process | viral penetration into host nucleus |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameLarge delta antigen
- Short namesL-HDAg
- Alternative names
Organism names
- Taxonomic lineageViruses > Ribozyviria > Kolmioviridae > Deltavirus > Hepatitis delta virus
- Virus hosts
Accessions
- Primary accessionP0C6L4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: isoprenylated in the cytoplasm, and translocates in the nucleus possibly after phosphorylation. Translocates after to nuclear speckle, then to the ER membrane where interaction with Hepatitis B virus antigene takes place (By similarity).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue, lipidation, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000038126 | 1-211 | Large delta antigen | |||
Sequence: MSQSETRRGRRGTREETLEKWITARKKAEELEKDLRKTRKTIKKLEEENPWLGNIVGIIRKGKDGEGAPPAKRPRTDQMEVDSGPGKRPHKSGFTDKEREDHRRRKALENKKKQLSAGGKILSKEEEEELRRLTDEDEERKRRVAGPRVGDVNPSRGGPRGAPGGGFVPQMAGVPESPFSRTGEGLDIRGTQGFPWVSPSPPQQRLPLLEC | ||||||
Modified residue | 2 | Phosphoserine; by host | ||||
Sequence: S | ||||||
Modified residue | 14 | Omega-N-methylated arginine; by host | ||||
Sequence: R | ||||||
Modified residue | 72 | N6-acetyllysine; by host | ||||
Sequence: K | ||||||
Modified residue | 123 | Phosphoserine; by host | ||||
Sequence: S | ||||||
Modified residue | 177 | Phosphoserine; by host | ||||
Sequence: S | ||||||
Modified residue | 211 | Cysteine methyl ester; by host | ||||
Sequence: C | ||||||
Lipidation | 211 | S-farnesyl cysteine; by host | ||||
Sequence: C | ||||||
Propeptide | PRO_0000396793 | 212-214 | Removed in mature form | |||
Sequence: TPQ |
Post-translational modification
Prenylated by host farnesyl-transferase in the cytoplasm prior to nucleus translocation.
Phosphorylated at serines by host CK2 and other kinases. phosphorylation does not seem to be important for its function (By similarity).
Keywords
- PTM
Interaction
Subunit
Homodimer. Homooctamer. Interacts with HBV HBsAg. May interact with clathrin to induce virion budding (By similarity).
Family & Domains
Features
Showing features for region, domain, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 13-60 | Dimerization | ||||
Sequence: TREETLEKWITARKKAEELEKDLRKTRKTIKKLEEENPWLGNIVGIIR | ||||||
Domain | 21-195 | HDAg | ||||
Sequence: WITARKKAEELEKDLRKTRKTIKKLEEENPWLGNIVGIIRKGKDGEGAPPAKRPRTDQMEVDSGPGKRPHKSGFTDKEREDHRRRKALENKKKQLSAGGKILSKEEEEELRRLTDEDEERKRRVAGPRVGDVNPSRGGPRGAPGGGFVPQMAGVPESPFSRTGEGLDIRGTQGFP | ||||||
Region | 58-214 | Disordered | ||||
Sequence: IIRKGKDGEGAPPAKRPRTDQMEVDSGPGKRPHKSGFTDKEREDHRRRKALENKKKQLSAGGKILSKEEEEELRRLTDEDEERKRRVAGPRVGDVNPSRGGPRGAPGGGFVPQMAGVPESPFSRTGEGLDIRGTQGFPWVSPSPPQQRLPLLECTPQ | ||||||
Compositional bias | 65-147 | Basic and acidic residues | ||||
Sequence: GEGAPPAKRPRTDQMEVDSGPGKRPHKSGFTDKEREDHRRRKALENKKKQLSAGGKILSKEEEEELRRLTDEDEERKRRVAGP | ||||||
Motif | 66-75 | Nuclear localization signal | ||||
Sequence: EGAPPAKRPR | ||||||
Region | 97-107 | RNA-binding | ||||
Sequence: KEREDHRRRKA | ||||||
Region | 130-195 | RNAPII-binding | ||||
Sequence: LRRLTDEDEERKRRVAGPRVGDVNPSRGGPRGAPGGGFVPQMAGVPESPFSRTGEGLDIRGTQGFP | ||||||
Region | 136-146 | RNA-binding | ||||
Sequence: EDEERKRRVAG |
Sequence similarities
Belongs to the hepatitis delta antigen family.
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length214
- Mass (Da)24,086
- Last updated2009-04-14 v1
- Checksum2562DEA7E2243FBD
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 65-147 | Basic and acidic residues | ||||
Sequence: GEGAPPAKRPRTDQMEVDSGPGKRPHKSGFTDKEREDHRRRKALENKKKQLSAGGKILSKEEEEELRRLTDEDEERKRRVAGP |
RNA Editing
Edited at position 196
Partially edited. RNA editing at this position occurs on the antigenomic strand and consists of a conversion of A to G catalyzed by the cellular enzyme ADAR1. The unedited RNA version gives rise to the small delta antigen (AC P69618), which ends with a nonsense codon at position 196. In the edited version, this amber codon is modified to a tryptophan codon and gives rise to the large delta antigen protein. S-HDAg suppresses editing of non-replicating antigenomic RNA, thereby regulating the extent of editing (By similarity)
Keywords
- Coding sequence diversity