P0C625 · HBEAG_HBVA3
- ProteinExternal core antigen
- GeneC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids214 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 185-186 | Cleavage; by host | ||||
Sequence: RS |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | host cell | |
Cellular Component | host cell cytoplasm | |
Cellular Component | host cell nucleus | |
Cellular Component | T=4 icosahedral viral capsid | |
Molecular Function | DNA binding | |
Molecular Function | RNA binding | |
Molecular Function | structural molecule activity | |
Biological Process | microtubule-dependent intracellular transport of viral material towards nucleus | |
Biological Process | symbiont entry into host cell | |
Biological Process | viral penetration into host nucleus | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameExternal core antigen
- Alternative names
Gene names
Organism names
- Taxonomic lineageViruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Blubervirales > Hepadnaviridae > Orthohepadnavirus > Hepatitis B virus
- Virus hosts
Accessions
- Primary accessionP0C625
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 122 | |||||
Sequence: V → M | ||||||
Natural variant | 126 | frequent mutation in chronic HBV carriers | ||||
Sequence: I → L | ||||||
Natural variant | 198 | |||||
Sequence: R → P |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MQLFHLCLIISCTCPTVQA | ||||||
Chain | PRO_0000315013 | 20-214 | External core antigen | |||
Sequence: SKLCLGWLWGMDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMTLATWVGNNLEDPASRDLVVNYVNTNVGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRDRGRSPRRRTPSPRRRRSPSPRRRRSQSRESQC | ||||||
Disulfide bond | 77 | Interchain | ||||
Sequence: C | ||||||
Disulfide bond | 90 | Interchain | ||||
Sequence: C | ||||||
Propeptide | PRO_0000314869 | 186-214 | ||||
Sequence: SPRRRTPSPRRRRSPSPRRRRSQSRESQC |
Post-translational modification
Keywords
- PTM
Interaction
Subunit
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 25-27 | HBEAG | ||||
Sequence: GWL | ||||||
Region | 165-214 | Disordered | ||||
Sequence: NAPILSTLPETTVVRRRDRGRSPRRRTPSPRRRRSPSPRRRRSQSRESQC | ||||||
Compositional bias | 182-204 | Basic residues | ||||
Sequence: DRGRSPRRRTPSPRRRRSPSPRR | ||||||
Repeat | 186-192 | 1; half-length | ||||
Sequence: SPRRRTP | ||||||
Region | 186-208 | 3 X 8 AA repeats of S-P-R-R-R-R-S-[PQ] | ||||
Sequence: SPRRRTPSPRRRRSPSPRRRRSQ | ||||||
Repeat | 193-200 | 2 | ||||
Sequence: SPRRRRSP | ||||||
Repeat | 201-208 | 3 | ||||
Sequence: SPRRRRSQ |
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative initiation.
P0C625-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameExternal core antigen
- Length214
- Mass (Da)24,580
- Last updated2008-01-15 v1
- Checksum56438263E63B46F6
P03148-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameCapsid protein
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 182-204 | Basic residues | ||||
Sequence: DRGRSPRRRTPSPRRRRSPSPRR |
Keywords
- Coding sequence diversity