P0C5V8 · PB1F2_I03A1
- ProteinProtein PB1-F2
- GenePB1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
Miscellaneous
Is not encoded in all strains, and seems to be dispensable for replication.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 66 | Low pathogenicity | ||||
Sequence: N |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell cytosol | |
Cellular Component | host cell mitochondrial inner membrane | |
Cellular Component | host cell nucleus | |
Cellular Component | membrane | |
Biological Process | apoptotic process | |
Biological Process | symbiont-mediated perturbation of host apoptosis | |
Biological Process | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein PB1-F2
Gene names
Organism names
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Alphainfluenzavirus > Alphainfluenzavirus influenzae > Influenza A virus
- Virus hosts
Accessions
- Primary accessionP0C5V8
Subcellular Location
UniProt Annotation
GO Annotation
Note: Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000311649 | 1-90 | Protein PB1-F2 | |||
Sequence: MEQGQDTPWTQSTEHTNIQKRGSGQQTQRLEHPNSTRLMDHYLRIMSPVGMHKQIVYWKQWLSLKNPTQESLKTRVLKRWKLFNKQEWIN |
Interaction
Subunit
Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1. Interacts with host MAVS.
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-33 | Polar residues | ||||
Sequence: MEQGQDTPWTQSTEHTNIQKRGSGQQTQRLEHP | ||||||
Region | 1-34 | Disordered | ||||
Sequence: MEQGQDTPWTQSTEHTNIQKRGSGQQTQRLEHPN | ||||||
Region | 65-87 | Mitochondrial targeting sequence | ||||
Sequence: KNPTQESLKTRVLKRWKLFNKQE |
Sequence similarities
Belongs to the influenza viruses PB1-F2 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length90
- Mass (Da)10,917
- Last updated2007-11-13 v1
- Checksum0F4E97AED546F678
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-33 | Polar residues | ||||
Sequence: MEQGQDTPWTQSTEHTNIQKRGSGQQTQRLEHP |