P0C5V8 · PB1F2_I03A1

Function

function

Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.

Miscellaneous

Is not encoded in all strains, and seems to be dispensable for replication.

Features

Showing features for site.

190102030405060708090
MEQGQDTPWTQSTEHTNIQKRGSGQQTQRLEHPNSTRLMDHYLRIMSPVGMHKQIVYWKQWLSLKNPTQESLKTRVLKRWKLFNKQEWIN
TypeIDPosition(s)Description
Site66Low pathogenicity

GO annotations

AspectTerm
Cellular Componenthost cell cytosol
Cellular Componenthost cell mitochondrial inner membrane
Cellular Componenthost cell nucleus
Cellular Componentmembrane
Biological Processapoptotic process
Biological Processsymbiont-mediated perturbation of host apoptosis
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein PB1-F2

Gene names

    • Name
      PB1

Organism names

Accessions

  • Primary accession
    P0C5V8

Subcellular Location

Host nucleus
Host cytoplasm, host cytosol
Note: Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003116491-90Protein PB1-F2

Interaction

Subunit

Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1. Interacts with host MAVS.

Structure

3D structure databases

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-33Polar residues
Region1-34Disordered
Region65-87Mitochondrial targeting sequence

Sequence similarities

Belongs to the influenza viruses PB1-F2 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    90
  • Mass (Da)
    10,917
  • Last updated
    2007-11-13 v1
  • Checksum
    0F4E97AED546F678
MEQGQDTPWTQSTEHTNIQKRGSGQQTQRLEHPNSTRLMDHYLRIMSPVGMHKQIVYWKQWLSLKNPTQESLKTRVLKRWKLFNKQEWIN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-33Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY651697
EMBL· GenBank· DDBJ
-Genomic RNA No translation available.

Similar Proteins

Disclaimer

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