P0C5A1 · DUS29_ORYLA
- ProteinDual specificity phosphatase 29
- Genedusp29
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids203 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity).
Involved in the modulation of AMPK and MAPK1/2 signaling pathways (By similarity).
Involved in the modulation of AMPK and MAPK1/2 signaling pathways (By similarity).
Catalytic activity
- O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 137-144 | substrate | |||
Active site | 138 | Phosphocysteine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | MAP kinase phosphatase activity | |
Molecular Function | myosin phosphatase activity | |
Molecular Function | protein tyrosine phosphatase activity | |
Molecular Function | protein tyrosine/serine/threonine phosphatase activity | |
Biological Process | negative regulation of MAPK cascade | |
Biological Process | protein dephosphorylation |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameDual specificity phosphatase 29
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias
Accessions
- Primary accessionP0C5A1
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000295888 | 1-203 | Dual specificity phosphatase 29 | ||
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 47-193 | Tyrosine-protein phosphatase | |||
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length203
- Mass (Da)23,002
- Last updated2007-07-24 v1
- MD5 Checksum8A0DF45075B145D32D772F92F7527DB5
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BAAF04042477 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |