P0C2P1 · BSD_ASPTN
- ProteinBlasticidin-S deaminase
- Genebsd
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids130 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the deamination of the cytosine moiety of the antibiotics blasticidin S, cytomycin and acetylblasticidin S.
Catalytic activity
- blasticidin S + H2O + H+ = deaminohydroxyblasticidin S + NH4+
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 28 | substrate; ligand shared between two homotetrameric partners; in other chain | ||||
Sequence: S | ||||||
Binding site | 54 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Active site | 56 | Proton donor | ||||
Sequence: E | ||||||
Binding site | 82 | substrate; ligand shared between two homotetrameric partners; in other chain | ||||
Sequence: R | ||||||
Binding site | 88 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Binding site | 91 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Binding site | 126 | substrate; ligand shared between two homotetrameric partners | ||||
Sequence: Y |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | blasticidin-S deaminase activity | |
Molecular Function | cytidine deaminase activity | |
Molecular Function | identical protein binding | |
Molecular Function | zinc ion binding | |
Biological Process | cytidine deamination | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBlasticidin-S deaminase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionP0C2P1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000283714 | 1-130 | Blasticidin-S deaminase | |||
Sequence: MPLSQEESTLIERATATINSIPISEDYSVASAALSSDGRIFTGVNVYHFTGGPCAELVVLGTAAAAAAGNLTCIVAIGNENRGILSPCGRCRQVLLDLHPGIKAVVKDSDGQPTAVGIRELLPSGYMNRA |
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-129 | CMP/dCMP-type deaminase | ||||
Sequence: MPLSQEESTLIERATATINSIPISEDYSVASAALSSDGRIFTGVNVYHFTGGPCAELVVLGTAAAAAAGNLTCIVAIGNENRGILSPCGRCRQVLLDLHPGIKAVVKDSDGQPTAVGIRELLPSGYMNR |
Sequence similarities
Belongs to the cytidine and deoxycytidylate deaminase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length130
- Mass (Da)13,455
- Last updated2007-04-03 v1
- Checksum9D77B27B0110EE24
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH476603 EMBL· GenBank· DDBJ | EAU32497.1 EMBL· GenBank· DDBJ | Genomic DNA |