P0C0Y5 · NMTDH_DAVTA

Function

function

Interconverts D-mannitol and D-fructose. Not active with fructose 6-phosphate or NADH.

Catalytic activity

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
1.17 μMD-fructose7.5
0.23 μMD-mannitol7.5
53 μMNADPH7.5
67 μMNADP+7.5

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site108NADP+ (UniProtKB | ChEBI)
Binding site141NADP+ (UniProtKB | ChEBI)
Active site160Proton donor
Active site175Proton acceptor
Binding site175NADP+ (UniProtKB | ChEBI)
Active site179Lowers pKa of active site Tyr
Binding site179NADP+ (UniProtKB | ChEBI)
Binding site207NADP+ (UniProtKB | ChEBI)
Binding site209NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmannitol 2-dehydrogenase (NADP+) activity
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
Molecular Functionprotein homodimerization activity
Biological Processmannitol metabolic process
Biological Processprotein homotetramerization

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    NADP-dependent mannitol dehydrogenase
  • EC number
  • Short names
    MtDH
  • Alternative names
    • Mannitol 2-dehydrogenase [NADP(+)]
  • Allergen name
    Cla h 8

Organism names

Accessions

  • Primary accession
    P0C0Y5
  • Secondary accessions
    • Q2TV79

Phenotypes & Variants

Allergenic properties

Causes an allergic reaction in human. Binds to IgE in 57% of 21 C.herbarum-allergic patients tested.

Keywords

Protein family/group databases

PTM/Processing

Features

Showing features for initiator methionine, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00000547282-267NADP-dependent mannitol dehydrogenase

Interaction

Subunit

Exists as monomer, dimer and tetramer.

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    267
  • Mass (Da)
    28,464
  • Last updated
    2006-01-24 v1
  • Checksum
    4CF5EA012D71D446
MPGQQATKHESLLDQLSLKGKVVVVTGASGPKGMGIEAARGCAEMGAAVAITYASRAQGAEENVKELEKTYGIKAKAYKCQVDSYESCEKLVKDVVADFGQIDAFIANAGATADSGILDGSVEAWNHVVQVDLNGTFHCAKAVGHHFKERGTGSLVITASMSGHIANFPQEQTSYNVAKAGCIHMARSLANEWRDFARVNSISPGYIDTGLSDFVPKETQQLWHSMIPMGRDGLAKELKGAYVYFASDASTYTTGADLLIDGGYTTR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY191816
EMBL· GenBank· DDBJ
AAO91801.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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