P0AFE8 · NUOM_ECOLI

Function

function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular ComponentNADH dehydrogenase complex
Cellular Componentplasma membrane
Cellular Componentrespiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular Functionubiquinone binding
Biological Processaerobic respiration
Biological ProcessATP synthesis coupled electron transport
Biological Processelectron transport coupled proton transport
Biological Processrespiratory electron transport chain

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 3.D.1.1.1the h+ or na+-translocating nadh dehydrogenase (ndh) family

Names & Taxonomy

Protein names

  • Recommended name
    NADH-quinone oxidoreductase subunit M
  • EC number
  • Alternative names
    • NADH dehydrogenase I subunit M
    • NDH-1 subunit M
    • NUO13

Gene names

    • Name
      nuoM
    • Ordered locus names
      b2277, JW2272

Organism names

  • Taxonomic identifier
  • Strains
    • K12 / AN387
    • K12 / W3110 / ATCC 27325 / DSM 5911
    • K12 / MG1655 / ATCC 47076
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    P0AFE8
  • Secondary accessions
    • P31978
    • P78248

Proteomes

Subcellular Location

Features

Showing features for transmembrane, topological domain.

TypeIDPosition(s)Description
Transmembrane1-21Helical
Topological domain22-29Cytoplasmic
Transmembrane30-50Helical
Topological domain51-82Periplasmic
Transmembrane83-103Helical
Topological domain104-121Cytoplasmic
Transmembrane122-142Helical
Topological domain143-173Periplasmic
Transmembrane174-194Helical
Topological domain195-221Cytoplasmic
Transmembrane222-242Helical
Topological domain243-258Periplasmic
Transmembrane259-279Helical
Topological domain280-285Cytoplasmic
Transmembrane286-306Helical
Topological domain307-313Periplasmic
Transmembrane314-334Helical
Topological domain335-339Cytoplasmic
Transmembrane340-360Helical
Topological domain361-382Periplasmic
Transmembrane383-403Helical
Transmembrane404-424Helical
Topological domain425Periplasmic
Transmembrane426-446Helical
Topological domain447-464Cytoplasmic
Transmembrane465-485Helical
Topological domain486-509Periplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001180391-509NADH-quinone oxidoreductase subunit M

Keywords

Proteomic databases

Interaction

Subunit

Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.

Complex viewer

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the complex I subunit 4 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    509
  • Mass (Da)
    56,525
  • Last updated
    2005-12-20 v1
  • Checksum
    3F8395683908EF97
MLLPWLILIPFIGGFLCWQTERFGVKVPRWIALITMGLTLALSLQLWLQGGYSLTQSAGIPQWQSEFDMPWIPRFGISIHLAIDGLSLLMVVLTGLLGVLAVLCSWKEIEKYQGFFHLNLMWILGGVIGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHKASDGKTRITAATKFFIYTQASGLVMLIAILALVFVHYNATGVWTFNYEELLNTPMSSGVEYLLMLGFFIAFAVKMPVVPLHGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFSLPLFPNASAEFAPIAMWLGVIGIFYGAWMAFAQTDIKRLIAYTSVSHMGFVLIAIYTGSQLAYQGAVIQMIAHGLSAAGLFILCGQLYERIHTRDMRMMGGLWSKMKWLPALSLFFAVATLGMPGTGNFVGEFMILFGSFQVVPVITVISTFGLVFASVYSLAMLHRAYFGKAKSQIASQELPGMSLRELFMILLLVVLLVLLGFYPQPILDTSHSAIGNIQQWFVNSVTTTRP

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict464-465in Ref. 1 and 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X68301
EMBL· GenBank· DDBJ
CAA48372.1
EMBL· GenBank· DDBJ
Genomic DNA
L19568
EMBL· GenBank· DDBJ
AAA53583.1
EMBL· GenBank· DDBJ
Genomic DNA
U00096
EMBL· GenBank· DDBJ
AAC75337.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009048
EMBL· GenBank· DDBJ
BAA16105.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp