P0AEG1 · DPPC_ECOLI
- ProteinDipeptide transport system permease protein DppC
- GenedppC
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids300 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Part of the ABC transporter DppABCDF involved in dipeptide transport (PubMed:7536291).
Responsible for the translocation of the substrate across the membrane (Probable)
Responsible for the translocation of the substrate across the membrane (Probable)
When a foreign outer membrane heme receptor is expressed in E.coli, DppABCDF can also transport heme and its precursor, 5-aminolevulinic acid (ALA), from the periplasm into the cytoplasm.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | dipeptide transmembrane transporter activity | |
Biological Process | dipeptide transport | |
Biological Process | heme transmembrane transport | |
Biological Process | peptide transport | |
Biological Process | protein transport |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDipeptide transport system permease protein DppC
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionP0AEG1
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-31 | Cytoplasmic | ||||
Sequence: MSQVTENKVISAPVPMTPLQEFWHYFKRNKG | ||||||
Transmembrane | 32-52 | Helical | ||||
Sequence: AVVGLVYVVIVLFIAIFANWI | ||||||
Topological domain | 53-101 | Periplasmic | ||||
Sequence: APYNPAEQFRDALLAPPAWQEGGSMAHLLGTDDVGRDVLSRLMYGARLS | ||||||
Transmembrane | 102-122 | Helical | ||||
Sequence: LLVGCLVVVLSLIMGVILGLI | ||||||
Topological domain | 123-136 | Cytoplasmic | ||||
Sequence: AGYFGGLVDNIIMR | ||||||
Transmembrane | 137-157 | Helical | ||||
Sequence: VVDIMLALPSLLLALVLVAIF | ||||||
Topological domain | 158-206 | Periplasmic | ||||
Sequence: GPSIGNAALALTFVALPHYVRLTRAAVLVEVNRDYVTASRVAGAGAMRQ | ||||||
Transmembrane | 207-227 | Helical | ||||
Sequence: MFINIFPNCLAPLIVQASLGF | ||||||
Topological domain | 228-230 | Cytoplasmic | ||||
Sequence: SNA | ||||||
Transmembrane | 231-251 | Helical | ||||
Sequence: ILDMAALGFLGMGAQPPTPEW | ||||||
Topological domain | 252-265 | Periplasmic | ||||
Sequence: GTMLSDVLQFAQSA | ||||||
Transmembrane | 266-286 | Helical | ||||
Sequence: WWVVTFPGLAILLTVLAFNLM | ||||||
Topological domain | 287-300 | Cytoplasmic | ||||
Sequence: GDGLRDALDPKLKQ |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Inactivation of the gene abolishes use of heme as an iron source.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000060009 | 1-300 | Dipeptide transport system permease protein DppC | |||
Sequence: MSQVTENKVISAPVPMTPLQEFWHYFKRNKGAVVGLVYVVIVLFIAIFANWIAPYNPAEQFRDALLAPPAWQEGGSMAHLLGTDDVGRDVLSRLMYGARLSLLVGCLVVVLSLIMGVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVAIFGPSIGNAALALTFVALPHYVRLTRAAVLVEVNRDYVTASRVAGAGAMRQMFINIFPNCLAPLIVQASLGFSNAILDMAALGFLGMGAQPPTPEWGTMLSDVLQFAQSAWWVVTFPGLAILLTVLAFNLMGDGLRDALDPKLKQ |
Proteomic databases
Interaction
Subunit
The complex is composed of two ATP-binding proteins (DppD and DppF), two transmembrane proteins (DppB and DppC) and a solute-binding protein (DppA) (PubMed:16905647, PubMed:7536291).
MppA can replace DppA as binding protein for heme and ALA transport (PubMed:16905647).
MppA can replace DppA as binding protein for heme and ALA transport (PubMed:16905647).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 98-287 | ABC transmembrane type-1 | ||||
Sequence: ARLSLLVGCLVVVLSLIMGVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVAIFGPSIGNAALALTFVALPHYVRLTRAAVLVEVNRDYVTASRVAGAGAMRQMFINIFPNCLAPLIVQASLGFSNAILDMAALGFLGMGAQPPTPEWGTMLSDVLQFAQSAWWVVTFPGLAILLTVLAFNLMG |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length300
- Mass (Da)32,308
- Last updated2005-12-06 v1
- ChecksumC4DD7BD82286EE62
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L08399 EMBL· GenBank· DDBJ | AAA23704.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U00039 EMBL· GenBank· DDBJ | AAB18520.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U00096 EMBL· GenBank· DDBJ | AAC76567.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009048 EMBL· GenBank· DDBJ | BAE77752.1 EMBL· GenBank· DDBJ | Genomic DNA |