P0AED7 · DAPE_ECOLI
- ProteinSuccinyl-diaminopimelate desuccinylase
- GenedapE
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids375 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
Miscellaneous
DapE/msgB is a multicopy suppressor of a temperature-sensitive allele of the heat shock gene grpE.
Catalytic activity
- H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate
Cofactor
Co2+ (UniProtKB | Rhea| CHEBI:48828 )
Note: Binds 2 Zn2+ or Co2+ ions per subunit.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
0.41 mM | L,L-SDAP | 7.0 | in the presence of Zn2+ |
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 66 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 68 | |||||
Sequence: D | ||||||
Binding site | 99 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 99 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 133 | Proton acceptor | ||||
Sequence: E | ||||||
Binding site | 134 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 162 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 348 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell division site | |
Cellular Component | cytosol | |
Molecular Function | cobalt ion binding | |
Molecular Function | identical protein binding | |
Molecular Function | succinyl-diaminopimelate desuccinylase activity | |
Molecular Function | zinc ion binding | |
Biological Process | diaminopimelate biosynthetic process | |
Biological Process | FtsZ-dependent cytokinesis | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSuccinyl-diaminopimelate desuccinylase
- EC number
- Short namesSDAP desuccinylase
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionP0AED7
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000185261 | 1-375 | Succinyl-diaminopimelate desuccinylase | |||
Sequence: MSCPVIELTQQLIRRPSLSPDDAGCQALLIERLQAIGFTVERMDFADTQNFWAWRGQGETLAFAGHTDVVPPGDADRWINPPFEPTIRDGMLFGRGAADMKGSLAAMVVAAERFVAQHPNHTGRLAFLITSDEEASAHNGTVKVVEALMARNERLDYCLVGEPSSIEVVGDVVKNGRRGSLTCNLTIHGVQGHVAYPHLADNPVHRAAPFLNELVAIEWDQGNEFFPATSMQIANIQAGTGSNNVIPGELFVQFNFRFSTELTDEMIKAQVLALLEKHQLRYTVDWWLSGQPFLTARGKLVDAVVNAVEHYNEIKPQLLTTGGTSDGRFIARMGAQVVELGPVNATIHKINECVNAADLQLLARMYQRIMEQLVA |
Proteomic databases
Structure
Sequence
- Sequence statusComplete
- Length375
- Mass (Da)41,269
- Last updated2005-12-06 v1
- Checksum181F43D05E88C20E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
S41760 EMBL· GenBank· DDBJ | AAB22798.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X57403 EMBL· GenBank· DDBJ | CAA40665.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U00096 EMBL· GenBank· DDBJ | AAC75525.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009048 EMBL· GenBank· DDBJ | BAA16346.1 EMBL· GenBank· DDBJ | Genomic DNA |