P0A9T3 · SERA_SHIFL

  • Protein
    D-3-phosphoglycerate dehydrogenase
  • Gene
    serA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

Catalytic activity

Activity regulation

In bacteria displays feedback inhibition by L-serine.

Pathway

Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site161-162NAD+ (UniProtKB | ChEBI)
Binding site181NAD+ (UniProtKB | ChEBI)
Binding site238-240NAD+ (UniProtKB | ChEBI)
Active site240
Binding site264NAD+ (UniProtKB | ChEBI)
Active site269
Active site292Proton donor
Binding site292-295NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNAD binding
Molecular Functionphosphoglycerate dehydrogenase activity
Biological ProcessL-serine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D-3-phosphoglycerate dehydrogenase
  • EC number
  • Short names
    PGDH
  • Alternative names
    • 2-oxoglutarate reductase
      (EC:1.1.1.399
      ) . EC:1.1.1.399 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      serA
    • Ordered locus names
      SF2898, S3098

Organism names

  • Taxonomic identifier
  • Strains
    • 301 / Serotype 2a
    • ATCC 700930 / 2457T / Serotype 2a
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Shigella

Accessions

  • Primary accession
    P0A9T3
  • Secondary accessions
    • P08328
    • Q47633

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for initiator methionine, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00000760062-410D-3-phosphoglycerate dehydrogenase

Proteomic databases

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain339-410ACT

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    410
  • Mass (Da)
    44,176
  • Last updated
    2007-01-23 v2
  • Checksum
    61EF5EFC304DF6F0
MAKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE005674
EMBL· GenBank· DDBJ
AAN44382.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014073
EMBL· GenBank· DDBJ
AAP18204.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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