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P0A4G6 · SECA_STRCO

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

1947100200300400500600700800900
TypeIDPosition(s)Description
Binding site85ATP (UniProtKB | ChEBI)
Binding site103-107ATP (UniProtKB | ChEBI)
Binding site514ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionprotein-exporting ATPase activity
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      SCE33.07c
    • Ordered locus names
      SCO3005

Organism names

Accessions

  • Primary accession
    P0A4G6
  • Secondary accessions
    • P55021
    • P95725
    • Q54396

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Note: Distribution is 50-50.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001096151-947Protein translocase subunit SecA

Proteomic databases

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region864-947Disordered

Sequence similarities

Belongs to the SecA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    947
  • Mass (Da)
    106,456
  • Last updated
    2005-03-15 v1
  • MD5 Checksum
    D718FBCE08D133BDDC54A74386584DA6
MSVLSKLMRAGEGKILRKLHRIADQVNSIEEDFADLSDAELRALTDEYKQRYADGESLDDLLPEAFATVREAAKRVLGQRHYDVQIMGGAALHMGYVAEMKTGEGKTLVGTLPAYLNALSGEGVHIVTVNDYLAERDSELMGRVHKFLGLNVGCILANQTPAQRREMYACDITYGTNNEFGFDYLRDNMAWSKDELVQRGHNFAIVDEVDSILVDEARTPLIISGPADQATKWYGDFAKLVTRLKKGEAGNTLKGIEETGDYEVDEKKRTVAIHESGVAKVEDWLGIDNLYESVNTPLVGYLNNAIKAKELFKKDKDYVVLDGEVMIVDEHTGRILAGRRYNEGMHQAIEAKEGVDIKDENQTLATITLQNFFRLYKRHDHDGKEQPGLSGMTGTAMTEAAEFHQIYKLGVVPIPTNRPMVRKDQSDLIYRTEVAKFEAVVDDIEEKHRKGQPILVGTTSVEKSEYLSQQLSKRGVQHEVLNAKQHDREATIVAQAGRKGSVTVATNMAGRGTDIKLGGNPEDLAEAELRQRGLDPEEHIEEWAAALPAALERAEQAVKAEFEEVKELGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDDLMRLFKAQMVERVMSMANVPDDVPIENKMVTRAIASAQSQVETQNFETRKNVLKYDEVLNRQREVIYGERRRVLEGEDLQEQIQHFTNDTIDAYVQAETAEGFPEDWDLDRLWGAFKQLYPVKVTVEELEEAAGDRAGLTADYIAESIKDDVREQYEAREKQLGSEIMRELERRVVLSVLDRKWREHLYEMDYLQEGIGLRAMAQKDPLVEYQREGFDMFQAMMDGIKEESVGYLFNLEVQVEQQVEEVPVEDAAPSLDKGAQDAVPAQAGARPEIRAKGLDAPQRRDLHFSAPTVDGEGGVVEGEFTDGEPAQAQSDGLTRAERRKQAKGGRRRKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X79813
EMBL· GenBank· DDBJ
CAA56209.1
EMBL· GenBank· DDBJ
Genomic DNA
AL939114
EMBL· GenBank· DDBJ
CAB90916.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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