P0A4G6 · SECA_STRCO
- ProteinProtein translocase subunit SecA
- GenesecA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids947 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Catalytic activity
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 85 | ATP (UniProtKB | ChEBI) | |||
Binding site | 103-107 | ATP (UniProtKB | ChEBI) | |||
Binding site | 514 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell envelope Sec protein transport complex | |
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | protein-exporting ATPase activity | |
Biological Process | intracellular protein transmembrane transport | |
Biological Process | protein import | |
Biological Process | protein targeting | |
Biological Process | protein transport by the Sec complex |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein translocase subunit SecA
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces > Streptomyces albidoflavus group
Accessions
- Primary accessionP0A4G6
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Note: Distribution is 50-50.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000109615 | 1-947 | Protein translocase subunit SecA | ||
Proteomic databases
Interaction
Subunit
Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
Protein-protein interaction databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length947
- Mass (Da)106,456
- Last updated2005-03-15 v1
- MD5 ChecksumD718FBCE08D133BDDC54A74386584DA6
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X79813 EMBL· GenBank· DDBJ | CAA56209.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL939114 EMBL· GenBank· DDBJ | CAB90916.1 EMBL· GenBank· DDBJ | Genomic DNA |