P0A0Y5 · GMHA_NEIMA

Function

function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.
Bacterial outer membrane biogenesis; LOS core biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site52-54substrate
Binding site61Zn2+ (UniProtKB | ChEBI)
Binding site65substrate
Binding site65Zn2+ (UniProtKB | ChEBI)
Binding site94-95substrate
Binding site120-122substrate
Binding site125substrate
Binding site175substrate
Binding site175Zn2+ (UniProtKB | ChEBI)
Binding site183Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarbohydrate derivative binding
Molecular FunctionD-sedoheptulose 7-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological Processcarbohydrate metabolic process
Biological ProcessD-glycero-D-manno-heptose 7-phosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoheptose isomerase
  • EC number
  • Alternative names
    • Sedoheptulose 7-phosphate isomerase

Gene names

    • Name
      gmhA
    • Synonyms
      lpcA
    • Ordered locus names
      NMA0340

Organism names

Accessions

  • Primary accession
    P0A0Y5
  • Secondary accessions
    • A1IPH1
    • Q9JQM1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001365381-197Phosphoheptose isomerase

Interaction

Subunit

Homotetramer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain37-197SIS

Sequence similarities

Belongs to the SIS family. GmhA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    197
  • Mass (Da)
    20,989
  • Last updated
    2005-03-01 v1
  • Checksum
    FAE0DA549A085280
MTTLQERVAAHFAESIRAKQEAGKVLVEPTVQAAELMLQCLMNDGKILACGNGGSAADAQHFAAEMTGRFEKERMELAAVALTTDTSALTAIGNDYGFDHVFSKQVRALGRAGDVLVGISTSGNSANVIEAVKAAHERDMHVIALTGRDGGKIAAILKDTDVLLNVPHPRTARIQENHILLIHAMCDCIDSVLLEGM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL157959
EMBL· GenBank· DDBJ
CAM07640.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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