P0A084 · MSRA1_STAA8
- ProteinPeptide methionine sulfoxide reductase MsrA 1
- GenemsrA1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids169 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
Catalytic activity
- [thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 + RHEA-COMP:12313 = RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3+ RHEA-COMP:12315
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 12 | |||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | L-methionine-(S)-S-oxide reductase activity | |
Molecular Function | peptide-methionine (S)-S-oxide reductase activity | |
Biological Process | cellular response to oxidative stress | |
Biological Process | protein modification process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeptide methionine sulfoxide reductase MsrA 1
- EC number
- Short namesProtein-methionine-S-oxide reductase 1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionP0A084
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000138589 | 1-169 | Peptide methionine sulfoxide reductase MsrA 1 | |||
Sequence: MNINTAYFAGGCFWCMTKPFDTFDGIEKVTSGYMGGHIENPTYEQVKSGTSGHLETVEIQYDVALFSYNKLLEIFFSVIDPLDTGGQYQDRGPQYQTAIFYTNDHQKELAETYIEQLKNTINADKAIATKILPASQFYKAEDYHQDFYKKNPERYAEEQKIRQEYKNKQ |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length169
- Mass (Da)19,611
- Last updated2005-03-01 v1
- Checksum6C5406148DAAC9A0
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF311784 EMBL· GenBank· DDBJ | AAK00894.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP000253 EMBL· GenBank· DDBJ | ABD30455.1 EMBL· GenBank· DDBJ | Genomic DNA |