P09959 · SWI6_YEAST
- ProteinRegulatory protein SWI6
- GeneSWI6
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids803 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Part of a complex involved in cell-cycle-dependent transcription. SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex. The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB).
Miscellaneous
Present with 3340 molecules/cell in log phase SD medium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | MBF transcription complex | |
Cellular Component | nucleus | |
Cellular Component | SBF transcription complex | |
Molecular Function | DNA binding | |
Molecular Function | transcription coactivator activity | |
Biological Process | cellular response to heat | |
Biological Process | G1/S transition of mitotic cell cycle | |
Biological Process | positive regulation of reciprocal meiotic recombination | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRegulatory protein SWI6
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP09959
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000067071 | 1-803 | Regulatory protein SWI6 | |||
Sequence: MALEEVVRYLGPHNEIPLTLTRDSETGHFLLKHFLPILQQYHDTGNINETNPDSFPTDEERNKLLAHYGIAVNTDDRGELWIELEKCLQLLNMLNLFGLFQDAFEFEEPETDQDEEDPSHSKLPENKTKSENSKDNISSKRINNLQDMSLDSDAHRELGSPLKKLKIDTSVIDAESDSTPNTARGKPNDDINKGPSGDNENNGTDDNDRTAGPIITFTHDLTSDFLSSPLKIMKALPSPVVNDNEQKMKLEAFLQRLLFPEIQEMPTSLNNDSSNRNSEGGSSNQQQQHVSFDSLLQEVNDAFPNTQLNLNIPVDEHGNTPLHWLTSIANLELVKHLVKHGSNRLYGDNMGESCLVKAVKSVNNYDSGTFEALLDYLYPCLILEDSMNRTILHHIIITSGMTGCSAAAKYYLDILMGWIVKKQNRPIQSGTNEKESKPNDKNGERKDSILENLDLKWIIANMLNAQDSNGDTCLNIAARLGNISIVDALLDYGADPFIANKSGLRPVDFGAGTSKLQNTNGGDENSKMVSKGDYDGQKNGKAKKIRSQLLKNPPETTSLINDVQNLLNSISKDYENETVQYNEKLEKLHKELNEQREELANSREQLANVKQLKDEYSLMQEQLTNLKAGIEEEEESFREESKKLGIIADESSGIDWDSSEYDADEPFKVEFLSDFLEDKLQKNYEGDISKLLEAESKEQIMEQIRNQLPAEKIQSMLPPTVLLKARINAYKRNDKHLTNVLDTISTKQSELENKFRRVLSLCLKIDENKVDNMLDGLLQAISSEDPQDIDTDEMQDFLKKHAS | ||||||
Modified residue | 149 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 160 | Phosphoserine; by CDC28 | ||||
Sequence: S | ||||||
Modified residue | 176 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 179 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 182 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 547 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylated by CDC28 and dephosphorylated by CDC14.
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Component of the transcription complex MCB-binding factor (MBF) composed of SWI6 and MBP1. Component of the transcription complex SCB-binding factor (SBF) composed of SWI6 and SWI4. Interacts with MSA1 and STB1.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P09959 | CLN3 P13365 | 2 | EBI-18641, EBI-4490 | |
BINARY | P09959 | MBP1 P39678 | 5 | EBI-18641, EBI-10485 | |
BINARY | P09959 | SWI4 P25302 | 9 | EBI-18641, EBI-18626 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 108-150 | Disordered | ||||
Sequence: EPETDQDEEDPSHSKLPENKTKSENSKDNISSKRINNLQDMSL | ||||||
Compositional bias | 115-136 | Basic and acidic residues | ||||
Sequence: EEDPSHSKLPENKTKSENSKDN | ||||||
Region | 169-212 | Disordered | ||||
Sequence: TSVIDAESDSTPNTARGKPNDDINKGPSGDNENNGTDDNDRTAG | ||||||
Compositional bias | 172-186 | Polar residues | ||||
Sequence: IDAESDSTPNTARGK | ||||||
Compositional bias | 194-212 | Polar residues | ||||
Sequence: GPSGDNENNGTDDNDRTAG | ||||||
Region | 266-288 | Disordered | ||||
Sequence: PTSLNNDSSNRNSEGGSSNQQQQ | ||||||
Repeat | 318-346 | ANK 1 | ||||
Sequence: GNTPLHWLTSIANLELVKHLVKHGSNRLY | ||||||
Repeat | 347-383 | ANK 2 | ||||
Sequence: GDNMGESCLVKAVKSVNNYDSGTFEALLDYLYPCLIL | ||||||
Repeat | 384-469 | ANK 3 | ||||
Sequence: EDSMNRTILHHIIITSGMTGCSAAAKYYLDILMGWIVKKQNRPIQSGTNEKESKPNDKNGERKDSILENLDLKWIIANMLNAQDSN | ||||||
Repeat | 470-498 | ANK 4 | ||||
Sequence: GDTCLNIAARLGNISIVDALLDYGADPFI | ||||||
Repeat | 499-514 | ANK 5 | ||||
Sequence: ANKSGLRPVDFGAGTS | ||||||
Compositional bias | 512-526 | Polar residues | ||||
Sequence: GTSKLQNTNGGDENS | ||||||
Region | 512-540 | Disordered | ||||
Sequence: GTSKLQNTNGGDENSKMVSKGDYDGQKNG |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length803
- Mass (Da)90,560
- Last updated1989-07-01 v1
- Checksum9B317FCACEEC493C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 115-136 | Basic and acidic residues | ||||
Sequence: EEDPSHSKLPENKTKSENSKDN | ||||||
Compositional bias | 172-186 | Polar residues | ||||
Sequence: IDAESDSTPNTARGK | ||||||
Compositional bias | 194-212 | Polar residues | ||||
Sequence: GPSGDNENNGTDDNDRTAG | ||||||
Compositional bias | 512-526 | Polar residues | ||||
Sequence: GTSKLQNTNGGDENS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X06238 EMBL· GenBank· DDBJ | CAA29581.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U17246 EMBL· GenBank· DDBJ | AAB67460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006945 EMBL· GenBank· DDBJ | DAA09502.1 EMBL· GenBank· DDBJ | Genomic DNA |