P09792 · GST28_SCHMA

Function

function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.

Miscellaneous

There are at least three isoenzymes of GST in S.mansoni.

Catalytic activity

Features

Showing features for binding site.

121120406080100120140160180200
TypeIDPosition(s)Description
Binding site10glutathione (UniProtKB | ChEBI)
Binding site10-11glutathione (UniProtKB | ChEBI)
Binding site16glutathione (UniProtKB | ChEBI)
Binding site41-45glutathione (UniProtKB | ChEBI)
Binding site53glutathione (UniProtKB | ChEBI)
Binding site55-56glutathione (UniProtKB | ChEBI)
Binding site70-71glutathione (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionglutathione transferase activity
Biological Processglutathione metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione S-transferase class-mu 28 kDa isozyme
  • EC number
  • Short names
    GST 28
  • Alternative names
    • GSH transferase S.m. 1-1
    • Protective 28 kDa antigen
    • Sm28 antigen
    • Sm28GST
    • Smp28

Gene names

    • Name
      GST28
    • ORF names
      Smp_054160

Organism names

  • Taxonomic identifier
  • Strain
    • Puerto Rican
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Trematoda > Digenea > Strigeidida > Schistosomatoidea > Schistosomatidae > Schistosoma

Accessions

  • Primary accession
    P09792
  • Secondary accessions
    • G4LZY1
    • Q7M446

Proteomes

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylalanine
ChainPRO_00001858152-211Glutathione S-transferase class-mu 28 kDa isozyme

Keywords

PTM databases

Expression

Tissue specificity

In the adult, expressed in excretory epithelial cells but absent from the caecal epithelium and flame cells. Also expressed in the tegument and its extensions into the parenchyma. In the schistosomulum, expressed in the tegument and associated structures. Not expressed in digestive tract, reproductive organs or muscles (at protein level).

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-86GST N-terminal
Domain88-211GST C-terminal

Sequence similarities

Belongs to the GST superfamily. Mu family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    211
  • Mass (Da)
    23,820
  • Last updated
    1989-07-01 v1
  • Checksum
    F988AAF041D767E3
MAGEHIKVIYFDGRGRAESIRMTLVAAGVDYEDERISFQDWPKIKPTIPGGRLPAVKVTDDHGHVKWMLESLAIARYMAKKHHMMGETDEEYYSVEKLIGQAEDVEHEYHKTLMKPQEEKEKITKEILNGKVPVLLNMICESLKGSTGKLAVGDKVTLADLVLIAVIDHVTDLDKGFLTGKYPEIHKHRENLLASSPRLAKYLSNRPATPF

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict47in Ref. 6; AA sequence
Sequence conflict106in Ref. 6; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X05148
EMBL· GenBank· DDBJ
CAA28796.1
EMBL· GenBank· DDBJ
mRNA
M98271
EMBL· GenBank· DDBJ
AAA29891.1
EMBL· GenBank· DDBJ
Genomic DNA
S71584
EMBL· GenBank· DDBJ
AAC60508.1
EMBL· GenBank· DDBJ
mRNA
CABG01000068
EMBL· GenBank· DDBJ
CCD60449.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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