P09703 · US27_HCMVA

Function

function

Interacts with the host Gi complex without activating it, thereby probably interfering with the chemokine-Gi signaling (PubMed:35061538).
May also function as a G protein sink to sequester G protein from the cell surface via internalization (PubMed:35061538).
Plays an important role in spread of HCMV via the extracellular route

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componenthost cell plasma membrane
Cellular Componentvirion component
Molecular FunctionC-C chemokine binding
Molecular FunctionC-C chemokine receptor activity
Biological Processcalcium-mediated signaling
Biological Processcell chemotaxis
Biological Processimmune response
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    G-protein coupled receptor homolog US27
  • Alternative names
    • HHRF2

Gene names

    • Name
      US27

Organism names

Accessions

  • Primary accession
    P09703
  • Secondary accessions
    • Q7M6H4

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-34Virion surface
Transmembrane35-58Helical; Name=1
Topological domain59-67Intravirion
Transmembrane68-90Helical; Name=2
Topological domain91-104Virion surface
Transmembrane105-126Helical; Name=3
Topological domain127-148Intravirion
Transmembrane149-167Helical; Name=4
Topological domain168-193Virion surface
Transmembrane194-213Helical; Name=5
Topological domain214-233Intravirion
Transmembrane234-257Helical; Name=6
Topological domain258-274Virion surface
Transmembrane275-298Helical; Name=7
Topological domain299-362Intravirion

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000702451-362G-protein coupled receptor homolog US27
Glycosylation7N-linked (GlcNAc...) asparagine; by host
Glycosylation15N-linked (GlcNAc...) asparagine; by host
Glycosylation18N-linked (GlcNAc...) asparagine; by host
Glycosylation22N-linked (GlcNAc...) asparagine; by host

Keywords

PTM databases

Interaction

Subunit

Heterodimer with US28 (PubMed:21684267).
Interacts with host Gi alpha-1 subunit GNAI1; this interaction does not lead to the catalytic activation of Gi complex (PubMed:35061538).

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region341-362Disordered

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    362
  • Mass (Da)
    41,994
  • Last updated
    1989-07-01 v1
  • Checksum
    D4C22064001EFECA
MTTSTNNQTLTQVSNMTNHTLNSTEIYQLFEYTRLGVWLMCIVGTFLNVLVITTILYYRRKKKSPSDTYICNLAVADLLIVVGLPFFLEYAKHHPKLSREVVCSGLNACFYICLFAGVCFLINLSMDRYCVIVWGVELNRVRNNKRATCWVVIFWILAVLMGMPHYLMYSHTNNECVGEFANETSGWFPVFLNTKVNICGYLAPIALMAYTYNRMVRFIINYVGKWHMQTLHVLLVVVVSFASFWFPFNLALFLESIRLLAGVYNDTLQNVIIFCLYVGQFLAYVRACLNPGIYILVGTQMRKDMWTTLRVFACCCVKQEIPYQDIDIELQKDIQRRAKHTKRTHYDRKNAPMESGEEEFLL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X17403
EMBL· GenBank· DDBJ
CAA35259.1
EMBL· GenBank· DDBJ
Genomic DNA
X04650
EMBL· GenBank· DDBJ
CAA28337.1
EMBL· GenBank· DDBJ
Genomic DNA
BK000394
EMBL· GenBank· DDBJ
DAA00214.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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