P09703 · US27_HCMVA
- ProteinG-protein coupled receptor homolog US27
- GeneUS27
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids362 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Interacts with the host Gi complex without activating it, thereby probably interfering with the chemokine-Gi signaling (PubMed:35061538).
May also function as a G protein sink to sequester G protein from the cell surface via internalization (PubMed:35061538).
Plays an important role in spread of HCMV via the extracellular route
May also function as a G protein sink to sequester G protein from the cell surface via internalization (PubMed:35061538).
Plays an important role in spread of HCMV via the extracellular route
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | external side of plasma membrane | |
Cellular Component | host cell plasma membrane | |
Cellular Component | virion component | |
Molecular Function | C-C chemokine binding | |
Molecular Function | C-C chemokine receptor activity | |
Biological Process | calcium-mediated signaling | |
Biological Process | cell chemotaxis | |
Biological Process | immune response | |
Biological Process | positive regulation of cytosolic calcium ion concentration | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameG-protein coupled receptor homolog US27
- Alternative names
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Betaherpesvirinae > Cytomegalovirus > Cytomegalovirus humanbeta5 > Human cytomegalovirus
- Virus hosts
Accessions
- Primary accessionP09703
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Host cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-34 | Virion surface | ||||
Sequence: MTTSTNNQTLTQVSNMTNHTLNSTEIYQLFEYTR | ||||||
Transmembrane | 35-58 | Helical; Name=1 | ||||
Sequence: LGVWLMCIVGTFLNVLVITTILYY | ||||||
Topological domain | 59-67 | Intravirion | ||||
Sequence: RRKKKSPSD | ||||||
Transmembrane | 68-90 | Helical; Name=2 | ||||
Sequence: TYICNLAVADLLIVVGLPFFLEY | ||||||
Topological domain | 91-104 | Virion surface | ||||
Sequence: AKHHPKLSREVVCS | ||||||
Transmembrane | 105-126 | Helical; Name=3 | ||||
Sequence: GLNACFYICLFAGVCFLINLSM | ||||||
Topological domain | 127-148 | Intravirion | ||||
Sequence: DRYCVIVWGVELNRVRNNKRAT | ||||||
Transmembrane | 149-167 | Helical; Name=4 | ||||
Sequence: CWVVIFWILAVLMGMPHYL | ||||||
Topological domain | 168-193 | Virion surface | ||||
Sequence: MYSHTNNECVGEFANETSGWFPVFLN | ||||||
Transmembrane | 194-213 | Helical; Name=5 | ||||
Sequence: TKVNICGYLAPIALMAYTYN | ||||||
Topological domain | 214-233 | Intravirion | ||||
Sequence: RMVRFIINYVGKWHMQTLHV | ||||||
Transmembrane | 234-257 | Helical; Name=6 | ||||
Sequence: LLVVVVSFASFWFPFNLALFLESI | ||||||
Topological domain | 258-274 | Virion surface | ||||
Sequence: RLLAGVYNDTLQNVIIF | ||||||
Transmembrane | 275-298 | Helical; Name=7 | ||||
Sequence: CLYVGQFLAYVRACLNPGIYILVG | ||||||
Topological domain | 299-362 | Intravirion | ||||
Sequence: TQMRKDMWTTLRVFACCCVKQEIPYQDIDIELQKDIQRRAKHTKRTHYDRKNAPMESGEEEFLL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000070245 | 1-362 | G-protein coupled receptor homolog US27 | |||
Sequence: MTTSTNNQTLTQVSNMTNHTLNSTEIYQLFEYTRLGVWLMCIVGTFLNVLVITTILYYRRKKKSPSDTYICNLAVADLLIVVGLPFFLEYAKHHPKLSREVVCSGLNACFYICLFAGVCFLINLSMDRYCVIVWGVELNRVRNNKRATCWVVIFWILAVLMGMPHYLMYSHTNNECVGEFANETSGWFPVFLNTKVNICGYLAPIALMAYTYNRMVRFIINYVGKWHMQTLHVLLVVVVSFASFWFPFNLALFLESIRLLAGVYNDTLQNVIIFCLYVGQFLAYVRACLNPGIYILVGTQMRKDMWTTLRVFACCCVKQEIPYQDIDIELQKDIQRRAKHTKRTHYDRKNAPMESGEEEFLL | ||||||
Glycosylation | 7 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Glycosylation | 15 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Glycosylation | 18 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Glycosylation | 22 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 341-362 | Disordered | ||||
Sequence: TKRTHYDRKNAPMESGEEEFLL |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length362
- Mass (Da)41,994
- Last updated1989-07-01 v1
- ChecksumD4C22064001EFECA
Keywords
- Technical term