P09631 · HXA9_MOUSE

  • Protein
    Homeobox protein Hox-A9
  • Gene
    Hoxa9
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cell surface at sites of inflammation (By similarity).
Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (PubMed:15657436).

Features

Showing features for dna binding.

127120406080100120140160180200220240260
TypeIDPosition(s)Description
DNA binding205-264Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componenttranscription regulator complex
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionenzyme binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processanterior/posterior pattern specification
Biological Processdefinitive hemopoiesis
Biological ProcessDNA-templated transcription
Biological Processembryonic forelimb morphogenesis
Biological Processembryonic skeletal system development
Biological Processembryonic skeletal system morphogenesis
Biological Processendothelial cell activation
Biological Processmale gonad development
Biological Processmammary gland development
Biological Processnegative regulation of myeloid cell differentiation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processprostate gland development
Biological Processproximal/distal pattern formation
Biological Processregulation of gene expression
Biological Processregulation of transcription by RNA polymerase II
Biological Processresponse to testosterone
Biological Processsingle fertilization
Biological Processspermatogenesis
Biological Processuterus development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Homeobox protein Hox-A9
  • Alternative names
    • Homeobox protein Hox-1.7

Gene names

    • Name
      Hoxa9
    • Synonyms
      Hox-1.7, Hoxa-9

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • ICR
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P09631
  • Secondary accessions
    • O70154
    • O70155

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis11Significant reduction in interaction with EIF4E.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 8 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002000821-271Homeobox protein Hox-A9
Modified residue139Symmetric dimethylarginine

Post-translational modification

Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in high level in the embryonic and adult spinal cord with a preference in the posterior region.

Gene expression databases

Interaction

Subunit

Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells (By similarity).
Interacts with EIF4E (PubMed:15657436).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P09631Ehmt2 Q9Z1482EBI-925334, EBI-444966
BINARY P09631Pbx1 P417782EBI-925334, EBI-6996259

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region154-197Disordered

Sequence similarities

Belongs to the Abd-B homeobox family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P09631-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    HoxA-9
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    271
  • Mass (Da)
    29,917
  • Last updated
    1999-07-15 v2
  • Checksum
    C1E679D9CBF677B0
MATTGALGNYYVDSFLLGADAADELGAGRYAPGTLGQPPRQAAALAEHPDFSPCSFQSKAAVFGASWNPVHAAGANAVPAAVYHHHHHPYVHPQAPVAAAAPDGRYMRSWLEPTPGALSFAGLPSSRPYGIKPEPLSARRGDCPTLDTHTLSLTDYACGSPPVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKINKDRAKDE

P09631-2

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_002382105in isoform HoxA-9T
Alternative sequenceVSP_002383106-271in isoform HoxA-9T

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB005457
EMBL· GenBank· DDBJ
BAA25800.1
EMBL· GenBank· DDBJ
mRNA
AB005458
EMBL· GenBank· DDBJ
BAA25801.1
EMBL· GenBank· DDBJ
mRNA
AB008914
EMBL· GenBank· DDBJ
BAA25802.1
EMBL· GenBank· DDBJ
Genomic DNA
BC055059
EMBL· GenBank· DDBJ
AAH55059.1
EMBL· GenBank· DDBJ
mRNA
M28449
EMBL· GenBank· DDBJ
AAA78790.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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