P09588 · H2A_CAEEL

  • Protein
    Histone H2A
  • Gene
    his-3; his-7; his-12; his-16; his-19; his-21; his-30; his-33; his-43; his-47; his-51; his-53; his-57; his-61; his-65; his-68
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleosome
Cellular Componentnucleus
Molecular Functionnucleosomal DNA binding
Molecular Functionprotein heterodimerization activity
Molecular Functionstructural constituent of chromatin
Biological ProcessDNA repair
Biological Processheterochromatin formation
Biological Processregulation of DNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone H2A

Gene names

    • Name
      his-3
    • ORF names
      T10C6.12
    • Name
      his-7
    • ORF names
      F45F2.4
    • Name
      his-12
    • ORF names
      ZK131.6
    • Name
      his-16
    • ORF names
      ZK131.10
    • Name
      his-19
    • ORF names
      K06C4.11

Organism names

  • Taxonomic identifier
  • Strains
    • Bristol N2
    • DR27
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    P09588
  • Secondary accessions
    • Q7JKF5

Proteomes

    • Identifier
    • Component
      Chromosome I, Chromosome II, Chromosome IV, Chromosome V

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, cross-link.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
Modified residue2Phosphoserine
ChainPRO_00000552102-127Histone H2A
Modified residue6N6-acetyllysine; partial
Modified residue9N6-acetyllysine; partial
Modified residue11N6-acetyllysine; partial
Modified residue106N5-methylglutamine
Cross-link121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Post-translational modification

Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-23Disordered

Sequence similarities

Belongs to the histone H2A family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    127
  • Mass (Da)
    13,405
  • Last updated
    2007-01-23 v2
  • Checksum
    FBF085558F1BD340
MSGRGKGGKAKTGGKAKSRSSRAGLQFPVGRLHRILRKGNYAQRVGAGAPVYLAAVLEYLAAEVLELAGNAARDNKKTRIAPRHLQLAVRNDEELNKLLAGVTIAQGGVLPNIQAVLLPKKTGGDKE

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
J7SA65J7SA65_CAEELhis-57147
J7S164J7S164_CAEELhis-57136

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X15633
EMBL· GenBank· DDBJ
CAA33641.1
EMBL· GenBank· DDBJ
Genomic DNA
FO081169
EMBL· GenBank· DDBJ
CCD69634.1
EMBL· GenBank· DDBJ
Genomic DNA
FO081135
EMBL· GenBank· DDBJ
CCD69397.1
EMBL· GenBank· DDBJ
Genomic DNA
FO081551
EMBL· GenBank· DDBJ
CCD72371.1
EMBL· GenBank· DDBJ
Genomic DNA
FO081551
EMBL· GenBank· DDBJ
CCD72361.1
EMBL· GenBank· DDBJ
Genomic DNA
FO081223
EMBL· GenBank· DDBJ
CCD70021.1
EMBL· GenBank· DDBJ
Genomic DNA
Z73102
EMBL· GenBank· DDBJ
CAA97414.1
EMBL· GenBank· DDBJ
Genomic DNA
Z81128
EMBL· GenBank· DDBJ
CAB03399.1
EMBL· GenBank· DDBJ
Genomic DNA
Z81495
EMBL· GenBank· DDBJ
CAB04056.1
EMBL· GenBank· DDBJ
Genomic DNA
Z82271
EMBL· GenBank· DDBJ
CAB05212.1
EMBL· GenBank· DDBJ
Genomic DNA
Z83245
EMBL· GenBank· DDBJ
CAB05836.1
EMBL· GenBank· DDBJ
Genomic DNA
Z83245
EMBL· GenBank· DDBJ
CAB05838.1
EMBL· GenBank· DDBJ
Genomic DNA
Z92789
EMBL· GenBank· DDBJ
CAB07221.1
EMBL· GenBank· DDBJ
Genomic DNA
Z93388
EMBL· GenBank· DDBJ
CAB07656.1
EMBL· GenBank· DDBJ
Genomic DNA
FO081059
EMBL· GenBank· DDBJ
CCD68872.1
EMBL· GenBank· DDBJ
Genomic DNA
FO081059
EMBL· GenBank· DDBJ
CCD68866.1
EMBL· GenBank· DDBJ
Genomic DNA
FO081018
EMBL· GenBank· DDBJ
CCD68534.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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