P09588 · H2A_CAEEL
- ProteinHistone H2A
- Genehis-3; his-7; his-12; his-16; his-19; his-21; his-30; his-33; his-43; his-47; his-51; his-53; his-57; his-61; his-65; his-68
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids127 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleosome | |
Cellular Component | nucleus | |
Molecular Function | nucleosomal DNA binding | |
Molecular Function | protein heterodimerization activity | |
Molecular Function | structural constituent of chromatin | |
Biological Process | DNA repair | |
Biological Process | heterochromatin formation | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone H2A
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionP09588
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylserine | ||||
Sequence: S | ||||||
Modified residue | 2 | Phosphoserine | ||||
Sequence: S | ||||||
Chain | PRO_0000055210 | 2-127 | Histone H2A | |||
Sequence: SGRGKGGKAKTGGKAKSRSSRAGLQFPVGRLHRILRKGNYAQRVGAGAPVYLAAVLEYLAAEVLELAGNAARDNKKTRIAPRHLQLAVRNDEELNKLLAGVTIAQGGVLPNIQAVLLPKKTGGDKE | ||||||
Modified residue | 6 | N6-acetyllysine; partial | ||||
Sequence: K | ||||||
Modified residue | 9 | N6-acetyllysine; partial | ||||
Sequence: K | ||||||
Modified residue | 11 | N6-acetyllysine; partial | ||||
Sequence: K | ||||||
Modified residue | 106 | N5-methylglutamine | ||||
Sequence: Q | ||||||
Cross-link | 121 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K |
Post-translational modification
Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-23 | Disordered | ||||
Sequence: MSGRGKGGKAKTGGKAKSRSSRA |
Sequence similarities
Belongs to the histone H2A family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length127
- Mass (Da)13,405
- Last updated2007-01-23 v2
- ChecksumFBF085558F1BD340
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X15633 EMBL· GenBank· DDBJ | CAA33641.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO081169 EMBL· GenBank· DDBJ | CCD69634.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO081135 EMBL· GenBank· DDBJ | CCD69397.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO081551 EMBL· GenBank· DDBJ | CCD72371.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO081551 EMBL· GenBank· DDBJ | CCD72361.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO081223 EMBL· GenBank· DDBJ | CCD70021.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z73102 EMBL· GenBank· DDBJ | CAA97414.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z81128 EMBL· GenBank· DDBJ | CAB03399.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z81495 EMBL· GenBank· DDBJ | CAB04056.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z82271 EMBL· GenBank· DDBJ | CAB05212.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z83245 EMBL· GenBank· DDBJ | CAB05836.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z83245 EMBL· GenBank· DDBJ | CAB05838.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z92789 EMBL· GenBank· DDBJ | CAB07221.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z93388 EMBL· GenBank· DDBJ | CAB07656.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO081059 EMBL· GenBank· DDBJ | CCD68872.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO081059 EMBL· GenBank· DDBJ | CCD68866.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO081018 EMBL· GenBank· DDBJ | CCD68534.1 EMBL· GenBank· DDBJ | Genomic DNA |