P09528 · FRIH_MOUSE

  • Protein
    Ferritin heavy chain
  • Gene
    Fth1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Stores iron in a soluble, non-toxic, readily available form (By similarity).
Important for iron homeostasis (By similarity).
Has ferroxidase activity (By similarity).
Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).
Also plays a role in delivery of iron to cells (PubMed:19154717).
Mediates iron uptake in capsule cells of the developing kidney (PubMed:19154717).
Degraded to release iron upon autophagy activation by nutrient starvation (PubMed:25327288).

Catalytic activity

Features

Showing features for binding site.

118220406080100120140160180
TypeIDPosition(s)Description
Binding site28Fe cation 1 (UniProtKB | ChEBI)
Binding site63Fe cation 1 (UniProtKB | ChEBI)
Binding site63Fe cation 2 (UniProtKB | ChEBI)
Binding site66Fe cation 1 (UniProtKB | ChEBI)
Binding site108Fe cation 2 (UniProtKB | ChEBI)
Binding site142Fe cation 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentautolysosome
Cellular Componentautophagosome
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentendocytic vesicle lumen
Cellular Componentextracellular region
Cellular Componentmembrane
Cellular Componentmitochondrion
Molecular Functionferric iron binding
Molecular Functionferrous iron binding
Molecular Functionferroxidase activity
Molecular Functionidentical protein binding
Molecular Functioniron ion binding
Molecular Functioniron ion sequestering activity
Biological Processimmune response
Biological Processintracellular sequestering of iron ion
Biological Processiron ion transport
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of ferroptosis
Biological Processnegative regulation of fibroblast proliferation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      Fth1
    • Synonyms
      Fth

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • ICR
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P09528
  • Secondary accessions
    • Q3UI44

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Homozygous mutant embryos die in utero between 3.5 and 9.5 dpc (PubMed:10652280).
Heterozygous animals are healthy and fertile and do not present any apparent abnormalities. They show slightly elevated tissue light chain ferritin content and 7- to 10-fold more light chain ferritin in the serum than normal mice, but their serum iron remains unchanged

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 21 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed; alternate
Modified residue1N-acetylmethionine
ChainPRO_00004244731-182Ferritin heavy chain
Modified residue2N-acetylthreonine; in Ferritin heavy chain, N-terminally processed
ChainPRO_00002010492-182Ferritin heavy chain, N-terminally processed

Keywords

Proteomic databases

2D gel databases

PTM databases

Expression

Developmental stage

At 9.5 dpc, detected at low levels in the developing heart and central nervous system. At later stages of development, widely expressed, predominantly in the heart and brown fat tissue.

Gene expression databases

Interaction

Subunit

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. Interacts with NCOA4; NCOA4 promotes targeting of the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P09528Fth1 P095283EBI-308950, EBI-308950

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-160Ferritin-like diiron

Sequence similarities

Belongs to the ferritin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    182
  • Mass (Da)
    21,067
  • Last updated
    2007-01-23 v2
  • Checksum
    129A8887A2BC650B
MTTASPSQVRQNYHQDAEAAINRQINLELYASYVYLSMSCYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWESGLNAMECALHLEKSVNQSLLELHKLATDKNDPHLCDFIETYYLSEQVKSIKELGDHVTNLRKMGAPEAGMAEYLFDKHTLGHGDES

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A494B9D4A0A494B9D4_MOUSEFth1116
A0A494BAP3A0A494BAP3_MOUSEFth159
A0A494BA92A0A494BA92_MOUSEFth1136

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict17in Ref. 5; AAA37612
Sequence conflict137in Ref. 5; AAA37612
Sequence conflict140in Ref. 5; AAA37612
Sequence conflict164in Ref. 5; AAA37612

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X52561
EMBL· GenBank· DDBJ
CAA36795.1
EMBL· GenBank· DDBJ
Genomic DNA
X12812
EMBL· GenBank· DDBJ
CAA31300.1
EMBL· GenBank· DDBJ
mRNA
J03941
EMBL· GenBank· DDBJ
AAA37611.1
EMBL· GenBank· DDBJ
mRNA
M60170
EMBL· GenBank· DDBJ
AAA37613.1
EMBL· GenBank· DDBJ
Genomic DNA
M24509
EMBL· GenBank· DDBJ
AAA37612.1
EMBL· GenBank· DDBJ
mRNA
AK027998
EMBL· GenBank· DDBJ
BAC25694.1
EMBL· GenBank· DDBJ
mRNA
AK139622
EMBL· GenBank· DDBJ
BAE24084.1
EMBL· GenBank· DDBJ
mRNA
AK147082
EMBL· GenBank· DDBJ
BAE27662.1
EMBL· GenBank· DDBJ
mRNA
AK150262
EMBL· GenBank· DDBJ
BAE29419.1
EMBL· GenBank· DDBJ
mRNA
AK150508
EMBL· GenBank· DDBJ
BAE29621.1
EMBL· GenBank· DDBJ
mRNA
AK150628
EMBL· GenBank· DDBJ
BAE29718.1
EMBL· GenBank· DDBJ
mRNA
AK150679
EMBL· GenBank· DDBJ
BAE29759.1
EMBL· GenBank· DDBJ
mRNA
AK150693
EMBL· GenBank· DDBJ
BAE29772.1
EMBL· GenBank· DDBJ
mRNA
AK151192
EMBL· GenBank· DDBJ
BAE30189.1
EMBL· GenBank· DDBJ
mRNA
AK151241
EMBL· GenBank· DDBJ
BAE30233.1
EMBL· GenBank· DDBJ
mRNA
AK151399
EMBL· GenBank· DDBJ
BAE30367.1
EMBL· GenBank· DDBJ
mRNA
AK151609
EMBL· GenBank· DDBJ
BAE30548.1
EMBL· GenBank· DDBJ
mRNA
AK151675
EMBL· GenBank· DDBJ
BAE30600.1
EMBL· GenBank· DDBJ
mRNA
AK152071
EMBL· GenBank· DDBJ
BAE30924.1
EMBL· GenBank· DDBJ
mRNA
AK152542
EMBL· GenBank· DDBJ
BAE31297.1
EMBL· GenBank· DDBJ
mRNA
AK152702
EMBL· GenBank· DDBJ
BAE31431.1
EMBL· GenBank· DDBJ
mRNA
AK153017
EMBL· GenBank· DDBJ
BAE31651.1
EMBL· GenBank· DDBJ
mRNA
AK153195
EMBL· GenBank· DDBJ
BAE31795.1
EMBL· GenBank· DDBJ
mRNA
AK153199
EMBL· GenBank· DDBJ
BAE31799.1
EMBL· GenBank· DDBJ
mRNA
AK159243
EMBL· GenBank· DDBJ
BAE34925.1
EMBL· GenBank· DDBJ
mRNA
AK168601
EMBL· GenBank· DDBJ
BAE40468.1
EMBL· GenBank· DDBJ
mRNA
AK169004
EMBL· GenBank· DDBJ
BAE40803.1
EMBL· GenBank· DDBJ
mRNA
BC012314
EMBL· GenBank· DDBJ
AAH12314.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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