P09225 · TNFB_MOUSE

  • Protein
    Lymphotoxin-alpha
  • Gene
    Lta
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity).
In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentplasma membrane
Molecular Functioncytokine activity
Molecular Functiontumor necrosis factor receptor binding
Biological Processdefense response to Gram-positive bacterium
Biological Processhumoral immune response
Biological Processinflammatory response
Biological Processlymph node development
Biological Processnegative regulation of fibroblast proliferation
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of chronic inflammatory response to antigenic stimulus
Biological Processpositive regulation of glial cell proliferation
Biological Processpositive regulation of humoral immune response mediated by circulating immunoglobulin
Biological Processpositive regulation of type II interferon production
Biological Processresponse to hypoxia
Biological Processresponse to lipopolysaccharide
Biological Processresponse to nutrient
Biological Processresponse to xenobiotic stimulus

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lymphotoxin-alpha
  • Short names
    LT-alpha
  • Alternative names
    • TNF-beta
    • Tumor necrosis factor ligand superfamily member 1

Gene names

    • Name
      Lta
    • Synonyms
      Tnfb, Tnfsf1

Organism names

  • Taxonomic identifier
  • Strain
    • 129
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P09225

Proteomes

Organism-specific databases

Subcellular Location

Secreted
Membrane
Note: The homotrimer is secreted. The heterotrimer is membrane-associated.

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-33
ChainPRO_000003446734-202Lymphotoxin-alpha
Glycosylation93N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain60-202THD

Sequence similarities

Belongs to the tumor necrosis factor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    202
  • Mass (Da)
    21,999
  • Last updated
    1989-07-01 v1
  • Checksum
    F496F83C685950D3
MTLLGRLHLLRVLGTPPVFLLGLLLALPLGAQGLSGVRFSAARTAHPLPQKHLTHGILKPAAHLVGYPSKQNSLLWRASTDRAFLRHGFSLSNNSLLIPTSGLYFVYSQVVFSGESCSPRAIPTPIYLAHEVQLFSSQYPFHVPLLSAQKSVYPGLQGPWVRSMYQGAVFLLSKGDQLSTHTDGISHLHFSPSSVFFGAFAL

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict26in Ref. 5; AAA39450
Sequence conflict161-162in Ref. 2; CAA29567

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U06950
EMBL· GenBank· DDBJ
AAA18593.1
EMBL· GenBank· DDBJ
Unassigned DNA
Y00467
EMBL· GenBank· DDBJ
CAA68529.1
EMBL· GenBank· DDBJ
Genomic DNA
X06217
EMBL· GenBank· DDBJ
CAA29566.1
EMBL· GenBank· DDBJ
Genomic DNA
X06218
EMBL· GenBank· DDBJ
CAA29567.1
EMBL· GenBank· DDBJ
Genomic DNA
Y00137
EMBL· GenBank· DDBJ
CAA68330.1
EMBL· GenBank· DDBJ
Genomic DNA
M16819
EMBL· GenBank· DDBJ
AAA40460.1
EMBL· GenBank· DDBJ
mRNA
M17015
EMBL· GenBank· DDBJ
AAA39450.1
EMBL· GenBank· DDBJ
Genomic DNA
AF109719
EMBL· GenBank· DDBJ
AAC82485.1
EMBL· GenBank· DDBJ
Genomic DNA
X14800
EMBL· GenBank· DDBJ
CAA32906.1
EMBL· GenBank· DDBJ
mRNA
M60586
EMBL· GenBank· DDBJ
AAA40461.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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