P09145 · HMEN_DROVI

Function

function

This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that repress activated promoters.

Features

Showing features for dna binding.

158450100150200250300350400450500550
TypeIDPosition(s)Description
DNA binding486-545Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processaxon guidance
Biological Processgenital disc anterior/posterior pattern formation
Biological Processgonad development
Biological Processimaginal disc-derived wing vein specification
Biological Processnegative regulation of gene expression
Biological Processnegative regulation of neuron apoptotic process
Biological Processneuroblast fate determination
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processsegment polarity determination
Biological Processspiracle morphogenesis, open tracheal system
Biological Processventral midline development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Segmentation polarity homeobox protein engrailed

Gene names

    • Name
      en

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila

Accessions

  • Primary accession
    P09145

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001960781-584Segmentation polarity homeobox protein engrailed

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-27Disordered
Region141-198Disordered
Compositional bias160-174Acidic residues
Compositional bias184-198Polar residues
Region343-380Disordered
Compositional bias392-414Polar residues
Region392-451Disordered
Compositional bias436-450Polar residues
Region465-492Disordered
Compositional bias468-492Basic and acidic residues

Sequence similarities

Belongs to the engrailed homeobox family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    584
  • Mass (Da)
    62,178
  • Last updated
    1989-07-01 v1
  • Checksum
    F556B03D60CD10B7
MALEDRCSPQSAPSPPGCLPHSPPQQHQHILQPNLRIHAIPISITALDMSLQPGTAATAATLYQQQQLQHLHQLQQLQQLHQQQLAASAGVFHHPSTSAAFDAAALHAAALQQRLSASGSPGAHSTGACSTPASTLTIKEEESDSILGDSFHNQTATTATEEDEEEDDDIDVDDTASVSGSARLPPPAHQQSKQSKPSLAFSISNILSDRFGDAAKQTKQGDSTGVSVSAAAAAASIFRPFEASRAAAATPSAFTRVDLLEFSRQQQAAAAAATAAMMLERANLLNCFNPAAYPRIHEELVQSRLRRSAAGNPNAVLPPTAKLTEPSVEKSALGSLCKTVSQIGQAQSTTPVTTPSSRPSQLASPPPASNASTISSSSSTAASCSASSSSGCSSAASSLNSSPSSRLAGANNASSPQPIPPPSAVSRDSGMESSDDTRSETGSTTTDGGKNEMWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTERRRQQLSSELGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTTVPLTKEEEELEMRMNGQIP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias160-174Acidic residues
Compositional bias184-198Polar residues
Compositional bias392-414Polar residues
Compositional bias436-450Polar residues
Compositional bias468-492Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X04727
EMBL· GenBank· DDBJ
CAA28436.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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