P09145 · HMEN_DROVI
- ProteinSegmentation polarity homeobox protein engrailed
- Geneen
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids584 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that repress activated promoters.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
DNA binding | 486-545 | Homeobox | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | axon guidance | |
Biological Process | genital disc anterior/posterior pattern formation | |
Biological Process | gonad development | |
Biological Process | imaginal disc-derived wing vein specification | |
Biological Process | negative regulation of gene expression | |
Biological Process | negative regulation of neuron apoptotic process | |
Biological Process | neuroblast fate determination | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | segment polarity determination | |
Biological Process | spiracle morphogenesis, open tracheal system | |
Biological Process | ventral midline development |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameSegmentation polarity homeobox protein engrailed
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila
Accessions
- Primary accessionP09145
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000196078 | 1-584 | Segmentation polarity homeobox protein engrailed | ||
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-27 | Disordered | |||
Region | 141-198 | Disordered | |||
Compositional bias | 160-174 | Acidic residues | |||
Compositional bias | 184-198 | Polar residues | |||
Region | 343-380 | Disordered | |||
Compositional bias | 392-414 | Polar residues | |||
Region | 392-451 | Disordered | |||
Compositional bias | 436-450 | Polar residues | |||
Region | 465-492 | Disordered | |||
Compositional bias | 468-492 | Basic and acidic residues | |||
Sequence similarities
Belongs to the engrailed homeobox family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length584
- Mass (Da)62,178
- Last updated1989-07-01 v1
- ChecksumF556B03D60CD10B7
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 160-174 | Acidic residues | |||
Compositional bias | 184-198 | Polar residues | |||
Compositional bias | 392-414 | Polar residues | |||
Compositional bias | 436-450 | Polar residues | |||
Compositional bias | 468-492 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X04727 EMBL· GenBank· DDBJ | CAA28436.1 EMBL· GenBank· DDBJ | Genomic DNA |