P08970 · SUHW_DROME
- ProteinProtein suppressor of hairy wing
- Genesu(Hw)
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids941 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein binds specifically to a region of the gypsy element located 3' of the 5' long terminal repeat (LTR), and may also mediate interaction with other endogenous insulators at sites distinct from those recognized by Cp190.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | nucleus | |
Molecular Function | chromatin binding | |
Molecular Function | chromatin insulator sequence binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | euchromatin binding | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | sequence-specific DNA binding | |
Biological Process | heterochromatin boundary formation | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | protein localization to euchromatin | |
Biological Process | regulation of transcription by RNA polymerase II | |
Biological Process | response to ecdysone |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein suppressor of hairy wing
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP08970
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with other elements of the gypsy chromatin insulator complex at multiple sites on polytene chromosomes and at nuclear insulator bodies.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000047053 | 1-941 | Protein suppressor of hairy wing | |||
Sequence: MSASKEGKEKKGKLLGVENISPPKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNKQEKRGSVAGSRIKILNEEILGTPKTEKRGATKSTAPAASTVKILNEKKTPSATVTAVETTKIKTSPSKRKKMEHYVLQAVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTEDDEDLGEDGDEDGEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKTHIRPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEGKHSPKQQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDIESEEVVPVALNTSAGSLISSQTDGNGVVVREFLVDEGDGAAQTITLENETYTILPLDGAIEGEQLTDEAGVKPEAKKEEAQVSPVVKKEQRKSLAASLAAAIADNLEESCSEDDFSGEILTEEDIKLKENVGKLIDMLVDPPILKKYGWPNAPEETVLCKVIENCGHDLTKGGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVLGDEDQDEGGLDKDNESHSGDEEAVSVTGETKTNEIREKPEKKEVSAKSEKKEIVGKAVDKDNSEEVVRENKKKPVGEQEKA | ||||||
Modified residue | 186 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
Expressed in all stages of development.
Gene expression databases
Interaction
Subunit
Component of the gypsy chromatin insulator complex, composed of Cp190, mod(mdg4) and su(Hw) (PubMed:11350941, PubMed:11416154, PubMed:15574329, PubMed:7664338).
The gypsy chromatin insulator complex interacts with Topors via mod(mdg4) and su(Hw) (PubMed:16209949).
Upon ecdysone stimulation, interacts with Nup98 (PubMed:28366641).
The gypsy chromatin insulator complex interacts with Topors via mod(mdg4) and su(Hw) (PubMed:16209949).
Upon ecdysone stimulation, interacts with Nup98 (PubMed:28366641).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P08970 | Cp190 Q24478 | 12 | EBI-101373, EBI-868840 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Basic and acidic residues | ||||
Sequence: MSASKEGKEKKGKLL | ||||||
Region | 1-97 | Disordered | ||||
Sequence: MSASKEGKEKKGKLLGVENISPPKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNKQEKRGSVAGSRIKILNEEILGTPKTEKRGATKSTAPAA | ||||||
Compositional bias | 42-64 | Polar residues | ||||
Sequence: EDSEASTTTTTSRTPSNKQEKRG | ||||||
Region | 176-211 | Disordered | ||||
Sequence: ENNNGQEIVVTEDDEDLGEDGDEDGEDSSGKGNSSQ | ||||||
Compositional bias | 183-201 | Acidic residues | ||||
Sequence: IVVTEDDEDLGEDGDEDGE | ||||||
Zinc finger | 220-242 | C2H2-type 1; atypical | ||||
Sequence: HVCGKCYKTFRRVQSLKKHLEFC | ||||||
Zinc finger | 290-313 | C2H2-type 2 | ||||
Sequence: INCPDCPKSFKTQTSYERHIFITH | ||||||
Zinc finger | 319-341 | C2H2-type 3; atypical | ||||
Sequence: FPCSICNANLRSEALLALHEEQH | ||||||
Zinc finger | 348-366 | C2H2-type 4 | ||||
Sequence: YACKICGKDFTRSYHLKRH | ||||||
Zinc finger | 380-402 | C2H2-type 5 | ||||
Sequence: MSCKVCDRVFYRLDNLRSHLKQH | ||||||
Zinc finger | 413-435 | C2H2-type 6 | ||||
Sequence: YMCHTCKNCFYSLSTLNIHIRTH | ||||||
Zinc finger | 441-463 | C2H2-type 7 | ||||
Sequence: FDCDLCDKKFSALVALKKHRRYH | ||||||
Zinc finger | 469-491 | C2H2-type 8 | ||||
Sequence: YSCTVCNQAFAVKEVLNRHMKRH | ||||||
Zinc finger | 497-519 | C2H2-type 9 | ||||
Sequence: HKCDECGKSFIQATQLRTHSKTH | ||||||
Zinc finger | 523-545 | C2H2-type 10 | ||||
Sequence: FPCEQCDEKFKTEKQLERHVKTH | ||||||
Zinc finger | 553-577 | C2H2-type 11 | ||||
Sequence: FSCAECKRNFRTPALLKEHMDEGKH | ||||||
Zinc finger | 596-619 | C2H2-type 12 | ||||
Sequence: TDCAICDKNFDSSDTLRRHIRTVH | ||||||
Region | 760-860 | Interaction with mod(mdg4) | ||||
Sequence: ILTEEDIKLKENVGKLIDMLVDPPILKKYGWPNAPEETVLCKVIENCGHDLTKGGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVL | ||||||
Region | 864-941 | Disordered | ||||
Sequence: DQDEGGLDKDNESHSGDEEAVSVTGETKTNEIREKPEKKEVSAKSEKKEIVGKAVDKDNSEEVVRENKKKPVGEQEKA | ||||||
Compositional bias | 870-884 | Basic and acidic residues | ||||
Sequence: LDKDNESHSGDEEAV | ||||||
Compositional bias | 891-941 | Basic and acidic residues | ||||
Sequence: KTNEIREKPEKKEVSAKSEKKEIVGKAVDKDNSEEVVRENKKKPVGEQEKA |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length941
- Mass (Da)105,780
- Last updated2003-08-15 v2
- Checksum60C6243AD088F961
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4K6W1 | A0A0B4K6W1_DROME | su(Hw) | 941 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Basic and acidic residues | ||||
Sequence: MSASKEGKEKKGKLL | ||||||
Sequence conflict | 31 | in Ref. 1; CAA68371 | ||||
Sequence: R → K | ||||||
Compositional bias | 42-64 | Polar residues | ||||
Sequence: EDSEASTTTTTSRTPSNKQEKRG | ||||||
Sequence conflict | 61 | in Ref. 1; CAA68371 | ||||
Sequence: E → G | ||||||
Sequence conflict | 64 | in Ref. 1; CAA68371 | ||||
Sequence: G → D | ||||||
Sequence conflict | 68 | in Ref. 1; CAA68371 | ||||
Sequence: G → E | ||||||
Compositional bias | 183-201 | Acidic residues | ||||
Sequence: IVVTEDDEDLGEDGDEDGE | ||||||
Sequence conflict | 249 | in Ref. 1; CAA68371 | ||||
Sequence: H → R | ||||||
Sequence conflict | 347 | in Ref. 1; CAA68371 | ||||
Sequence: P → S | ||||||
Sequence conflict | 508 | in Ref. 1; CAA68371 | ||||
Sequence: Q → R | ||||||
Sequence conflict | 667 | in Ref. 1; CAA68371 | ||||
Sequence: G → D | ||||||
Compositional bias | 870-884 | Basic and acidic residues | ||||
Sequence: LDKDNESHSGDEEAV | ||||||
Sequence conflict | 874 | in Ref. 1; CAA68371 | ||||
Sequence: N → NEDN | ||||||
Compositional bias | 891-941 | Basic and acidic residues | ||||
Sequence: KTNEIREKPEKKEVSAKSEKKEIVGKAVDKDNSEEVVRENKKKPVGEQEKA | ||||||
Sequence conflict | 892 | in Ref. 1; CAA68371 | ||||
Sequence: T → K | ||||||
Sequence conflict | 896 | in Ref. 1; CAA68371 | ||||
Sequence: R → K | ||||||
Sequence conflict | 923 | in Ref. 1; CAA68371 | ||||
Sequence: S → T |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Y00228 EMBL· GenBank· DDBJ | CAA68371.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AAF55044.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT003273 EMBL· GenBank· DDBJ | AAO25030.1 EMBL· GenBank· DDBJ | mRNA |