P08678 · CYAA_YEAST
- ProteinAdenylate cyclase
- GeneCYR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids2026 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphateThis reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Activity regulation
The presence of GTP-bound RAS2 protein is required in order to elicit a magnesium-dependent adenylyl cyclase activity.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | mitochondrion | |
Cellular Component | plasma membrane | |
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Biological Process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | |
Biological Process | cAMP biosynthetic process | |
Biological Process | positive regulation of Ras protein signal transduction | |
Biological Process | Ras protein signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylate cyclase
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP08678
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 1651 | Attenuation of the response to Ras proteins. | ||||
Sequence: T → D | ||||||
Mutagenesis | 1651 | Weak Ras-independent activity. | ||||
Sequence: T → I |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 27 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylserine | ||||
Sequence: S | ||||||
Chain | PRO_0000195731 | 2-2026 | Adenylate cyclase | |||
Sequence: SSKPDTGSEISGPQRQEEQEQQIEQSSPTEANDRSIHDEVPKVKKRHEQNSGHKSRRNSAYSYYSPRSLSMTKSRESITPNGMDDVSISNVEHPRPTEPKIKRGPYLLKKTLSSLSMTSANSTHDDNKDHGYALNSSKTHNYTSTHNHHDGHHDHHHVQFFPNRKPSLAETLFKRFSGSNSHDGNKSGKESKVANLSLSTVNPAPANRKPSKDSTLSNHLADNVPSTLRRKVSSLVRGSSVHDINNGIADKQIRPKAVAQSENTLHSSDVPNSKRSHRKSFLLGSTSSSSSRRGSNVSSMTNSDSASMATSGSHVLQHNVSNVSPTTKSKDSVNSESADHTNNKSEKVTPEYNENIPENSNSDNKREATTPTIETPISCKPSLFRLDTNLEDVTDITKTVPPTAVNSTLNSTHGTETASPKTVIMPEGPRKSVSMADLSVAAAAPNGEFTSTSNDRSQWVAPQSWDVETKRKKTKPKGRSKSRRSSIDADELDPMSPGPPSKKDSRHHHDRKDNESMVTAGDSNSSFVDICKENVPNDSKTALDTKSVNRLKSNLAMSPPSIRYAPSNLDGDYDTSSTSSSLPSSSISSEDTSSCSDSSSYTNAYMEANREQDNKTPILNKTKSYTKKFTSSSVNMNSPDGAQSSGLLLQDEKDDEVECQLEHYYKDFSDLDPKRHYAIRIFNTDDTFTTLSCTPATTVEEIIPALKRKFNITAQGNFQISLKVGKLSKILRPTSKPILIERKLLLLNGYRKSDPLHIMGIEDLSFVFKFLFHPVTPSHFTPEQEQRIMRSEFVHVDLRNMDLTTPPIIFYQHTSEIESLDVSNNANIFLPLEFIESSIKLLSLRMVNIRASKFPSNITKAYKLVSLELQRNFIRKVPNSIMKLSNLTILNLQCNELESLPAGFVELKNLQLLDLSSNKFMHYPEVINYCTNLLQIDLSYNKIQSLPQSTKYLVKLAKMNLSHNKLNFIGDLSEMTDLRTLNLRYNRISSIKTNASNLQNLFLTDNRISNFEDTLPKLRALEIQENPITSISFKDFYPKNMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQEISKLTKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNIRDFVDGMENLELTSLNISSNAFGNSSLENSFYHNMSYGSKLSKSLMFFIAADNQFDDAMWPLFNCFVNLKVLNLSYNNFSDVSHMKLESITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAELSNLSQLSVFDVGANQLKYNISNYHYDWNWRNNKELKYLNFSGNRRFEIKSFISHDIDADLSDLTVLPQLKVLGLMDVTLNTTKVPDENVNFRLRTTASIINGMRYGVADTLGQRDYVSSRDVTFERFRGNDDECLLCLHDSKNQNADYGHNISRIVRDIYDKILIRQLERYGDETDDNIKTALRFSFLQLNKEINGMLNSVDNGADVANLSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLLPHIHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENSTDPLRAAAELKDHAMAYGCTENITILCLALYENIQQQNRFTLNKNSLMTRRSTFEDTTLRRLQPEISPPTGNLAMVFTDIKSSTFLWELFPNAMRTAIKTHNDIMRRQLRIYGGYEVKTEGDAFMVAFPTPTSGLTWCLSVQLKLLDAQWPEEITSVQDGCQVTDRNGNIIYQGLSVRMGIHWGCPVPELDLVTQRMDYLGPMVNKAARVQGVADGGQIAMSSDFYSEFNKIMKYHERVVKGKESLKEVYGEEIIGEVLEREIAMLESIGWAFFDFGEHKLKGLETKELVTIAYPKILASRHEFASEDEQSKLINETMLFRLRVISNRLESIMSALSGGFIELDSRTEGSYIKFNPKVENGIMQSISEKDALLFFDHVITRIESSVALLHLRQQRCSGLEICRNDKTSARSNIFNVVDELLQMVKNAKDLST | ||||||
Modified residue | 376 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 389 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 433 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 487 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 497 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 562 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P08678 | GPA2 P10823 | 3 | EBI-5364, EBI-7382 | |
BINARY | P08678 | SRV2 P17555 | 6 | EBI-5364, EBI-4024 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-31 | Polar residues | ||||
Sequence: MSSKPDTGSEISGPQRQEEQEQQIEQSSPTE | ||||||
Region | 1-104 | Disordered | ||||
Sequence: MSSKPDTGSEISGPQRQEEQEQQIEQSSPTEANDRSIHDEVPKVKKRHEQNSGHKSRRNSAYSYYSPRSLSMTKSRESITPNGMDDVSISNVEHPRPTEPKIKR | ||||||
Compositional bias | 32-47 | Basic and acidic residues | ||||
Sequence: ANDRSIHDEVPKVKKR | ||||||
Compositional bias | 56-87 | Polar residues | ||||
Sequence: SRRNSAYSYYSPRSLSMTKSRESITPNGMDDV | ||||||
Region | 119-160 | Disordered | ||||
Sequence: TSANSTHDDNKDHGYALNSSKTHNYTSTHNHHDGHHDHHHVQ | ||||||
Compositional bias | 144-160 | Basic and acidic residues | ||||
Sequence: TSTHNHHDGHHDHHHVQ | ||||||
Region | 200-223 | Disordered | ||||
Sequence: STVNPAPANRKPSKDSTLSNHLAD | ||||||
Region | 247-378 | Disordered | ||||
Sequence: NGIADKQIRPKAVAQSENTLHSSDVPNSKRSHRKSFLLGSTSSSSSRRGSNVSSMTNSDSASMATSGSHVLQHNVSNVSPTTKSKDSVNSESADHTNNKSEKVTPEYNENIPENSNSDNKREATTPTIETPI | ||||||
Compositional bias | 279-333 | Polar residues | ||||
Sequence: RKSFLLGSTSSSSSRRGSNVSSMTNSDSASMATSGSHVLQHNVSNVSPTTKSKDS | ||||||
Compositional bias | 334-348 | Basic and acidic residues | ||||
Sequence: VNSESADHTNNKSEK | ||||||
Compositional bias | 349-378 | Polar residues | ||||
Sequence: VTPEYNENIPENSNSDNKREATTPTIETPI | ||||||
Compositional bias | 405-420 | Polar residues | ||||
Sequence: AVNSTLNSTHGTETAS | ||||||
Region | 405-429 | Disordered | ||||
Sequence: AVNSTLNSTHGTETASPKTVIMPEG | ||||||
Compositional bias | 447-465 | Polar residues | ||||
Sequence: NGEFTSTSNDRSQWVAPQS | ||||||
Region | 447-523 | Disordered | ||||
Sequence: NGEFTSTSNDRSQWVAPQSWDVETKRKKTKPKGRSKSRRSSIDADELDPMSPGPPSKKDSRHHHDRKDNESMVTAGD | ||||||
Compositional bias | 501-518 | Basic and acidic residues | ||||
Sequence: PSKKDSRHHHDRKDNESM | ||||||
Region | 559-601 | Disordered | ||||
Sequence: SPPSIRYAPSNLDGDYDTSSTSSSLPSSSISSEDTSSCSDSSS | ||||||
Compositional bias | 571-601 | Polar residues | ||||
Sequence: DGDYDTSSTSSSLPSSSISSEDTSSCSDSSS | ||||||
Domain | 676-755 | Ras-associating | ||||
Sequence: RHYAIRIFNTDDTFTTLSCTPATTVEEIIPALKRKFNITAQGNFQISLKVGKLSKILRPTSKPILIERKLLLLNGYRKSD | ||||||
Repeat | 795-814 | LRR 1 | ||||
Sequence: VHVDLRNMDLTTPPIIFYQH | ||||||
Repeat | 815-838 | LRR 2 | ||||
Sequence: TSEIESLDVSNNANIFLPLEFIES | ||||||
Repeat | 842-862 | LRR 3 | ||||
Sequence: LLSLRMVNIRASKFPSNITKA | ||||||
Repeat | 863-885 | LRR 4 | ||||
Sequence: YKLVSLELQRNFIRKVPNSIMKL | ||||||
Repeat | 886-908 | LRR 5 | ||||
Sequence: SNLTILNLQCNELESLPAGFVEL | ||||||
Repeat | 910-931 | LRR 6 | ||||
Sequence: NLQLLDLSSNKFMHYPEVINYC | ||||||
Repeat | 932-955 | LRR 7 | ||||
Sequence: TNLLQIDLSYNKIQSLPQSTKYLV | ||||||
Repeat | 957-976 | LRR 8 | ||||
Sequence: LAKMNLSHNKLNFIGDLSEM | ||||||
Repeat | 977-999 | LRR 9 | ||||
Sequence: TDLRTLNLRYNRISSIKTNASNL | ||||||
Repeat | 1001-1016 | LRR 10 | ||||
Sequence: NLFLTDNRISNFEDTL | ||||||
Repeat | 1017-1040 | LRR 11 | ||||
Sequence: PKLRALEIQENPITSISFKDFYPK | ||||||
Repeat | 1042-1062 | LRR 12 | ||||
Sequence: MTSLTLNKAQLSSIPGELLTK | ||||||
Repeat | 1063-1086 | LRR 13 | ||||
Sequence: LSFLEKLELNQNNLTRLPQEISKL | ||||||
Repeat | 1088-1109 | LRR 14 | ||||
Sequence: KLVFLSVARNKLEYIPPELSQL | ||||||
Repeat | 1110-1132 | LRR 15 | ||||
Sequence: KSLRTLDLHSNNIRDFVDGMENL | ||||||
Repeat | 1134-1156 | LRR 16 | ||||
Sequence: LTSLNISSNAFGNSSLENSFYHN | ||||||
Repeat | 1188-1209 | LRR 17 | ||||
Sequence: FVNLKVLNLSYNNFSDVSHMKL | ||||||
Repeat | 1210-1232 | LRR 18 | ||||
Sequence: ESITELYLSGNKLTTLSGDTVLK | ||||||
Repeat | 1233-1256 | LRR 19 | ||||
Sequence: WSSLKTLMLNSNQMLSLPAELSNL | ||||||
Repeat | 1258-1280 | LRR 20 | ||||
Sequence: QLSVFDVGANQLKYNISNYHYDW | ||||||
Repeat | 1285-1308 | LRR 21 | ||||
Sequence: NKELKYLNFSGNRRFEIKSFISHD | ||||||
Repeat | 1319-1344 | LRR 22 | ||||
Sequence: LPQLKVLGLMDVTLNTTKVPDENVNF | ||||||
Domain | 1357-1624 | PPM-type phosphatase | ||||
Sequence: RYGVADTLGQRDYVSSRDVTFERFRGNDDECLLCLHDSKNQNADYGHNISRIVRDIYDKILIRQLERYGDETDDNIKTALRFSFLQLNKEINGMLNSVDNGADVANLSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLLPHIHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENSTDPLRAAAELKDHAMAYGCTENITILCLAL | ||||||
Domain | 1668-1805 | Guanylate cyclase | ||||
Sequence: AMVFTDIKSSTFLWELFPNAMRTAIKTHNDIMRRQLRIYGGYEVKTEGDAFMVAFPTPTSGLTWCLSVQLKLLDAQWPEEITSVQDGCQVTDRNGNIIYQGLSVRMGIHWGCPVPELDLVTQRMDYLGPMVNKAARVQ |
Sequence similarities
Belongs to the adenylyl cyclase class-3 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,026
- Mass (Da)227,834
- Last updated1995-11-01 v2
- ChecksumBEAB7419AB6989D0
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-31 | Polar residues | ||||
Sequence: MSSKPDTGSEISGPQRQEEQEQQIEQSSPTE | ||||||
Compositional bias | 32-47 | Basic and acidic residues | ||||
Sequence: ANDRSIHDEVPKVKKR | ||||||
Compositional bias | 56-87 | Polar residues | ||||
Sequence: SRRNSAYSYYSPRSLSMTKSRESITPNGMDDV | ||||||
Compositional bias | 144-160 | Basic and acidic residues | ||||
Sequence: TSTHNHHDGHHDHHHVQ | ||||||
Sequence conflict | 262 | in Ref. 1; AAA34549 | ||||
Sequence: S → L | ||||||
Compositional bias | 279-333 | Polar residues | ||||
Sequence: RKSFLLGSTSSSSSRRGSNVSSMTNSDSASMATSGSHVLQHNVSNVSPTTKSKDS | ||||||
Compositional bias | 334-348 | Basic and acidic residues | ||||
Sequence: VNSESADHTNNKSEK | ||||||
Compositional bias | 349-378 | Polar residues | ||||
Sequence: VTPEYNENIPENSNSDNKREATTPTIETPI | ||||||
Compositional bias | 405-420 | Polar residues | ||||
Sequence: AVNSTLNSTHGTETAS | ||||||
Compositional bias | 447-465 | Polar residues | ||||
Sequence: NGEFTSTSNDRSQWVAPQS | ||||||
Compositional bias | 501-518 | Basic and acidic residues | ||||
Sequence: PSKKDSRHHHDRKDNESM | ||||||
Sequence conflict | 548 | in Ref. 1; AAA34549 | ||||
Sequence: S → L | ||||||
Compositional bias | 571-601 | Polar residues | ||||
Sequence: DGDYDTSSTSSSLPSSSISSEDTSSCSDSSS | ||||||
Sequence conflict | 592 | in Ref. 1; AAA34549 | ||||
Sequence: D → H | ||||||
Sequence conflict | 709 | in Ref. 1; AAA34549 | ||||
Sequence: R → I | ||||||
Sequence conflict | 962 | in Ref. 1; AAA34549 | ||||
Sequence: L → P | ||||||
Sequence conflict | 1388 | in Ref. 1; AAA34549 | ||||
Sequence: L → S | ||||||
Sequence conflict | 1427 | in Ref. 4; CAA27175 | ||||
Sequence: E → D | ||||||
Sequence conflict | 1461 | in Ref. 4; CAA27175 | ||||
Sequence: A → T | ||||||
Sequence conflict | 1566 | in Ref. 1; AAA34549 | ||||
Sequence: A → S | ||||||
Sequence conflict | 1735 | in Ref. 1; AAA34549 | ||||
Sequence: V → G | ||||||
Sequence conflict | 1956 | in Ref. 4; CAA27175 | ||||
Sequence: I → V | ||||||
Sequence conflict | 1996 | in Ref. 1; AAA34549 | ||||
Sequence: C → F | ||||||
Sequence conflict | 2009-2026 | in Ref. 4; CAA27175 | ||||
Sequence: NVVDELLQMVKNAKDLST → MLLTNFYKWLRTQRIYQLEFCS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M12057 EMBL· GenBank· DDBJ | AAA34549.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z49280 EMBL· GenBank· DDBJ | CAA89295.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X87611 EMBL· GenBank· DDBJ | CAA60917.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X03449 EMBL· GenBank· DDBJ | CAA27175.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006943 EMBL· GenBank· DDBJ | DAA08786.1 EMBL· GenBank· DDBJ | Genomic DNA |