P08678 · CYAA_YEAST

Function

function

Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Activity regulation

The presence of GTP-bound RAS2 protein is required in order to elicit a magnesium-dependent adenylyl cyclase activity.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site1673Mg2+ (UniProtKB | ChEBI)
Binding site1716Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrion
Cellular Componentplasma membrane
Molecular Functionadenylate cyclase activity
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Biological Processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological ProcesscAMP biosynthetic process
Biological Processpositive regulation of Ras protein signal transduction
Biological ProcessRas protein signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate cyclase
  • EC number
  • Alternative names
    • ATP pyrophosphate-lyase
    • Adenylyl cyclase

Gene names

    • Name
      CYR1
    • Synonyms
      CDC35, HSR1, SRA4
    • ORF names
      J1401
    • Ordered locus names
      YJL005W

Organism names

Accessions

  • Primary accession
    P08678
  • Secondary accessions
    • D6VWH0

Proteomes

Organism-specific databases

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis1651Attenuation of the response to Ras proteins.
Mutagenesis1651Weak Ras-independent activity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 27 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
ChainPRO_00001957312-2026Adenylate cyclase
Modified residue376Phosphothreonine
Modified residue389Phosphothreonine
Modified residue433Phosphoserine
Modified residue487Phosphoserine
Modified residue497Phosphoserine
Modified residue562Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P08678GPA2 P108233EBI-5364, EBI-7382
BINARY P08678SRV2 P175556EBI-5364, EBI-4024

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain, repeat.

TypeIDPosition(s)Description
Compositional bias1-31Polar residues
Region1-104Disordered
Compositional bias32-47Basic and acidic residues
Compositional bias56-87Polar residues
Region119-160Disordered
Compositional bias144-160Basic and acidic residues
Region200-223Disordered
Region247-378Disordered
Compositional bias279-333Polar residues
Compositional bias334-348Basic and acidic residues
Compositional bias349-378Polar residues
Compositional bias405-420Polar residues
Region405-429Disordered
Compositional bias447-465Polar residues
Region447-523Disordered
Compositional bias501-518Basic and acidic residues
Region559-601Disordered
Compositional bias571-601Polar residues
Domain676-755Ras-associating
Repeat795-814LRR 1
Repeat815-838LRR 2
Repeat842-862LRR 3
Repeat863-885LRR 4
Repeat886-908LRR 5
Repeat910-931LRR 6
Repeat932-955LRR 7
Repeat957-976LRR 8
Repeat977-999LRR 9
Repeat1001-1016LRR 10
Repeat1017-1040LRR 11
Repeat1042-1062LRR 12
Repeat1063-1086LRR 13
Repeat1088-1109LRR 14
Repeat1110-1132LRR 15
Repeat1134-1156LRR 16
Repeat1188-1209LRR 17
Repeat1210-1232LRR 18
Repeat1233-1256LRR 19
Repeat1258-1280LRR 20
Repeat1285-1308LRR 21
Repeat1319-1344LRR 22
Domain1357-1624PPM-type phosphatase
Domain1668-1805Guanylate cyclase

Sequence similarities

Belongs to the adenylyl cyclase class-3 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,026
  • Mass (Da)
    227,834
  • Last updated
    1995-11-01 v2
  • Checksum
    BEAB7419AB6989D0
MSSKPDTGSEISGPQRQEEQEQQIEQSSPTEANDRSIHDEVPKVKKRHEQNSGHKSRRNSAYSYYSPRSLSMTKSRESITPNGMDDVSISNVEHPRPTEPKIKRGPYLLKKTLSSLSMTSANSTHDDNKDHGYALNSSKTHNYTSTHNHHDGHHDHHHVQFFPNRKPSLAETLFKRFSGSNSHDGNKSGKESKVANLSLSTVNPAPANRKPSKDSTLSNHLADNVPSTLRRKVSSLVRGSSVHDINNGIADKQIRPKAVAQSENTLHSSDVPNSKRSHRKSFLLGSTSSSSSRRGSNVSSMTNSDSASMATSGSHVLQHNVSNVSPTTKSKDSVNSESADHTNNKSEKVTPEYNENIPENSNSDNKREATTPTIETPISCKPSLFRLDTNLEDVTDITKTVPPTAVNSTLNSTHGTETASPKTVIMPEGPRKSVSMADLSVAAAAPNGEFTSTSNDRSQWVAPQSWDVETKRKKTKPKGRSKSRRSSIDADELDPMSPGPPSKKDSRHHHDRKDNESMVTAGDSNSSFVDICKENVPNDSKTALDTKSVNRLKSNLAMSPPSIRYAPSNLDGDYDTSSTSSSLPSSSISSEDTSSCSDSSSYTNAYMEANREQDNKTPILNKTKSYTKKFTSSSVNMNSPDGAQSSGLLLQDEKDDEVECQLEHYYKDFSDLDPKRHYAIRIFNTDDTFTTLSCTPATTVEEIIPALKRKFNITAQGNFQISLKVGKLSKILRPTSKPILIERKLLLLNGYRKSDPLHIMGIEDLSFVFKFLFHPVTPSHFTPEQEQRIMRSEFVHVDLRNMDLTTPPIIFYQHTSEIESLDVSNNANIFLPLEFIESSIKLLSLRMVNIRASKFPSNITKAYKLVSLELQRNFIRKVPNSIMKLSNLTILNLQCNELESLPAGFVELKNLQLLDLSSNKFMHYPEVINYCTNLLQIDLSYNKIQSLPQSTKYLVKLAKMNLSHNKLNFIGDLSEMTDLRTLNLRYNRISSIKTNASNLQNLFLTDNRISNFEDTLPKLRALEIQENPITSISFKDFYPKNMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQEISKLTKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNIRDFVDGMENLELTSLNISSNAFGNSSLENSFYHNMSYGSKLSKSLMFFIAADNQFDDAMWPLFNCFVNLKVLNLSYNNFSDVSHMKLESITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAELSNLSQLSVFDVGANQLKYNISNYHYDWNWRNNKELKYLNFSGNRRFEIKSFISHDIDADLSDLTVLPQLKVLGLMDVTLNTTKVPDENVNFRLRTTASIINGMRYGVADTLGQRDYVSSRDVTFERFRGNDDECLLCLHDSKNQNADYGHNISRIVRDIYDKILIRQLERYGDETDDNIKTALRFSFLQLNKEINGMLNSVDNGADVANLSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLLPHIHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENSTDPLRAAAELKDHAMAYGCTENITILCLALYENIQQQNRFTLNKNSLMTRRSTFEDTTLRRLQPEISPPTGNLAMVFTDIKSSTFLWELFPNAMRTAIKTHNDIMRRQLRIYGGYEVKTEGDAFMVAFPTPTSGLTWCLSVQLKLLDAQWPEEITSVQDGCQVTDRNGNIIYQGLSVRMGIHWGCPVPELDLVTQRMDYLGPMVNKAARVQGVADGGQIAMSSDFYSEFNKIMKYHERVVKGKESLKEVYGEEIIGEVLEREIAMLESIGWAFFDFGEHKLKGLETKELVTIAYPKILASRHEFASEDEQSKLINETMLFRLRVISNRLESIMSALSGGFIELDSRTEGSYIKFNPKVENGIMQSISEKDALLFFDHVITRIESSVALLHLRQQRCSGLEICRNDKTSARSNIFNVVDELLQMVKNAKDLST

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-31Polar residues
Compositional bias32-47Basic and acidic residues
Compositional bias56-87Polar residues
Compositional bias144-160Basic and acidic residues
Sequence conflict262in Ref. 1; AAA34549
Compositional bias279-333Polar residues
Compositional bias334-348Basic and acidic residues
Compositional bias349-378Polar residues
Compositional bias405-420Polar residues
Compositional bias447-465Polar residues
Compositional bias501-518Basic and acidic residues
Sequence conflict548in Ref. 1; AAA34549
Compositional bias571-601Polar residues
Sequence conflict592in Ref. 1; AAA34549
Sequence conflict709in Ref. 1; AAA34549
Sequence conflict962in Ref. 1; AAA34549
Sequence conflict1388in Ref. 1; AAA34549
Sequence conflict1427in Ref. 4; CAA27175
Sequence conflict1461in Ref. 4; CAA27175
Sequence conflict1566in Ref. 1; AAA34549
Sequence conflict1735in Ref. 1; AAA34549
Sequence conflict1956in Ref. 4; CAA27175
Sequence conflict1996in Ref. 1; AAA34549
Sequence conflict2009-2026in Ref. 4; CAA27175

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M12057
EMBL· GenBank· DDBJ
AAA34549.1
EMBL· GenBank· DDBJ
Genomic DNA
Z49280
EMBL· GenBank· DDBJ
CAA89295.1
EMBL· GenBank· DDBJ
Genomic DNA
X87611
EMBL· GenBank· DDBJ
CAA60917.1
EMBL· GenBank· DDBJ
Genomic DNA
X03449
EMBL· GenBank· DDBJ
CAA27175.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006943
EMBL· GenBank· DDBJ
DAA08786.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp