P08591 · SOMA_PAGMA

Function

function

Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation.

Features

Showing features for binding site.

120320406080100120140160180200
TypeIDPosition(s)Description
Binding site36Zn2+ (UniProtKB | ChEBI)
Binding site185Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functiongrowth hormone activity
Molecular Functiongrowth hormone receptor binding
Molecular Functionmetal ion binding
Biological Processanimal organ development
Biological Processgrowth hormone receptor signaling pathway
Biological Processpositive regulation of growth
Biological Processpositive regulation of receptor signaling pathway via JAK-STAT
Biological Processpositive regulation of tyrosine phosphorylation of STAT protein
Biological Processresponse to nutrient levels

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Somatotropin
  • Alternative names
    • Growth hormone

Gene names

    • Name
      gh

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Spariformes > Sparidae > Pagrus

Accessions

  • Primary accession
    P08591

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, modified residue, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-17
Modified residue18Pyrrolidone carboxylic acid
ChainPRO_000003304418-203Somatotropin
Disulfide bond68↔176
Disulfide bond193↔201

Keywords

Structure

Family & Domains

Sequence similarities

Belongs to the somatotropin/prolactin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    203
  • Mass (Da)
    22,900
  • Last updated
    1988-08-01 v1
  • Checksum
    BCF9B35C7F20CC33
MDRVVLMLSVLSLGVSSQPITDGQRLFSIAVSRVQHLHLLAQRLFSDFESSLQTEEQLKLNKIFPDFCNSDYIISPIDKHETQRSSVLKLLSISYRLVESWEFPSRSLSGGSAPRNQISPKLSELKMGIHLLIRANEDGAEIFPDSSALQLAPYGNYYQSLGADESLRRTYELLACFKKDMHKVETYLTVAKCRLSPEANCTL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X06962
EMBL· GenBank· DDBJ
CAA30033.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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