P08173 · ACM4_HUMAN

  • Protein
    Muscarinic acetylcholine receptor M4
  • Gene
    CHRM4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentdendrite
Cellular Componentplasma membrane
Cellular Componentpostsynaptic membrane
Cellular Componentsynapse
Molecular FunctionG protein-coupled acetylcholine receptor activity
Molecular FunctionG protein-coupled serotonin receptor activity
Biological Processadenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
Biological Processcell surface receptor signaling pathway
Biological Processchemical synaptic transmission
Biological ProcessG protein-coupled acetylcholine receptor signaling pathway
Biological ProcessG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Processregulation of locomotion
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Muscarinic acetylcholine receptor M4

Gene names

    • Name
      CHRM4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P08173
  • Secondary accessions
    • B2RPP4
    • Q0VD60
    • Q4VBK7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-31Extracellular
Transmembrane32-54Helical; Name=1
Topological domain55-68Cytoplasmic
Transmembrane69-89Helical; Name=2
Topological domain90-106Extracellular
Transmembrane107-128Helical; Name=3
Topological domain129-148Cytoplasmic
Transmembrane149-171Helical; Name=4
Topological domain172-193Extracellular
Transmembrane194-216Helical; Name=5
Topological domain217-401Cytoplasmic
Transmembrane402-422Helical; Name=6
Topological domain423-436Extracellular
Transmembrane437-456Helical; Name=7
Topological domain457-479Cytoplasmic

Keywords

Disease & Variants

Variants

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The viewer provides 430 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000690371-479Muscarinic acetylcholine receptor M4
Glycosylation8N-linked (GlcNAc...) asparagine
Glycosylation13N-linked (GlcNAc...) asparagine
Disulfide bond105↔185
Modified residue459Phosphothreonine
Modified residue463Phosphothreonine
Modified residue477Phosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

    • ENSG00000180720Expressed in male germ line stem cell (sensu Vertebrata) in testis and 86 other cell types or tissues

Organism-specific databases

Interaction

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region271-333Disordered
Compositional bias290-322Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    479
  • Mass (Da)
    53,049
  • Last updated
    2002-09-19 v2
  • Checksum
    9C1B05B359A64289
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias290-322Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M16405
EMBL· GenBank· DDBJ
AAA51571.2
EMBL· GenBank· DDBJ
Genomic DNA
X15265
EMBL· GenBank· DDBJ
CAA33336.1
EMBL· GenBank· DDBJ
Genomic DNA
AF498918
EMBL· GenBank· DDBJ
AAM18941.1
EMBL· GenBank· DDBJ
mRNA
CH471064
EMBL· GenBank· DDBJ
EAW68004.1
EMBL· GenBank· DDBJ
Genomic DNA
BC095546
EMBL· GenBank· DDBJ
AAH95546.1
EMBL· GenBank· DDBJ
mRNA
BC119775
EMBL· GenBank· DDBJ
AAI19776.1
EMBL· GenBank· DDBJ
mRNA
BC119817
EMBL· GenBank· DDBJ
AAI19818.1
EMBL· GenBank· DDBJ
mRNA
BC137535
EMBL· GenBank· DDBJ
AAI37536.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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