P08173 · ACM4_HUMAN
- ProteinMuscarinic acetylcholine receptor M4
- GeneCHRM4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids479 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | dendrite | |
Cellular Component | plasma membrane | |
Cellular Component | postsynaptic membrane | |
Cellular Component | synapse | |
Molecular Function | G protein-coupled acetylcholine receptor activity | |
Molecular Function | G protein-coupled serotonin receptor activity | |
Biological Process | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway | |
Biological Process | cell surface receptor signaling pathway | |
Biological Process | chemical synaptic transmission | |
Biological Process | G protein-coupled acetylcholine receptor signaling pathway | |
Biological Process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | |
Biological Process | regulation of locomotion | |
Biological Process | signal transduction |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMuscarinic acetylcholine receptor M4
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP08173
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Postsynaptic cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-31 | Extracellular | ||||
Sequence: MANFTPVNGSSGNQSVRLVTSSSHNRYETVE | ||||||
Transmembrane | 32-54 | Helical; Name=1 | ||||
Sequence: MVFIATVTGSLSLVTVVGNILVM | ||||||
Topological domain | 55-68 | Cytoplasmic | ||||
Sequence: LSIKVNRQLQTVNN | ||||||
Transmembrane | 69-89 | Helical; Name=2 | ||||
Sequence: YFLFSLACADLIIGAFSMNLY | ||||||
Topological domain | 90-106 | Extracellular | ||||
Sequence: TVYIIKGYWPLGAVVCD | ||||||
Transmembrane | 107-128 | Helical; Name=3 | ||||
Sequence: LWLALDYVVSNASVMNLLIISF | ||||||
Topological domain | 129-148 | Cytoplasmic | ||||
Sequence: DRYFCVTKPLTYPARRTTKM | ||||||
Transmembrane | 149-171 | Helical; Name=4 | ||||
Sequence: AGLMIAAAWVLSFVLWAPAILFW | ||||||
Topological domain | 172-193 | Extracellular | ||||
Sequence: QFVVGKRTVPDNQCFIQFLSNP | ||||||
Transmembrane | 194-216 | Helical; Name=5 | ||||
Sequence: AVTFGTAIAAFYLPVVIMTVLYI | ||||||
Topological domain | 217-401 | Cytoplasmic | ||||
Sequence: HISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRT | ||||||
Transmembrane | 402-422 | Helical; Name=6 | ||||
Sequence: IFAILLAFILTWTPYNVMVLV | ||||||
Topological domain | 423-436 | Extracellular | ||||
Sequence: NTFCQSCIPDTVWS | ||||||
Transmembrane | 437-456 | Helical; Name=7 | ||||
Sequence: IGYWLCYVNSTINPACYALC | ||||||
Topological domain | 457-479 | Cytoplasmic | ||||
Sequence: NATFKKTFRHLLLCQYRNIGTAR |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 430 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069037 | 1-479 | Muscarinic acetylcholine receptor M4 | |||
Sequence: MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR | ||||||
Glycosylation | 8 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 13 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 105↔185 | |||||
Sequence: CDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQC | ||||||
Modified residue | 459 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 463 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 477 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 271-333 | Disordered | ||||
Sequence: KLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRAL | ||||||
Compositional bias | 290-322 | Polar residues | ||||
Sequence: KDTSNESSSGSATQNTKERPATELSTTEATTPA |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length479
- Mass (Da)53,049
- Last updated2002-09-19 v2
- Checksum9C1B05B359A64289
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 290-322 | Polar residues | ||||
Sequence: KDTSNESSSGSATQNTKERPATELSTTEATTPA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M16405 EMBL· GenBank· DDBJ | AAA51571.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
X15265 EMBL· GenBank· DDBJ | CAA33336.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF498918 EMBL· GenBank· DDBJ | AAM18941.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471064 EMBL· GenBank· DDBJ | EAW68004.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC095546 EMBL· GenBank· DDBJ | AAH95546.1 EMBL· GenBank· DDBJ | mRNA | ||
BC119775 EMBL· GenBank· DDBJ | AAI19776.1 EMBL· GenBank· DDBJ | mRNA | ||
BC119817 EMBL· GenBank· DDBJ | AAI19818.1 EMBL· GenBank· DDBJ | mRNA | ||
BC137535 EMBL· GenBank· DDBJ | AAI37536.1 EMBL· GenBank· DDBJ | mRNA |