P08118 · MSMB_HUMAN
- ProteinBeta-microseminoprotein
- GeneMSMB
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids114 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Miscellaneous
Specific receptors for this protein are found on spermatozoa and in the prostate.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | nucleus |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBeta-microseminoprotein
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP08118
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Involvement in disease
Prostate cancer, hereditary, 13 (HPC13)
- Note
- DescriptionA condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
- See alsoMIM:611928
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_011935 | 17 | in dbSNP:rs1804776 | |||
Sequence: L → S | ||||||
Natural variant | VAR_011936 | 25 | in dbSNP:rs1804778 | |||
Sequence: I → M | ||||||
Natural variant | VAR_011937 | 52 | in dbSNP:rs1804780 | |||
Sequence: W → R | ||||||
Natural variant | VAR_011938 | 53 | in dbSNP:rs1804468 | |||
Sequence: Q → R | ||||||
Natural variant | VAR_011939 | 80 | in dbSNP:rs1802774 | |||
Sequence: D → A | ||||||
Natural variant | VAR_011940 | 87 | in dbSNP:rs1802771 | |||
Sequence: I → T | ||||||
Natural variant | VAR_011941 | 91 | in dbSNP:rs1804469 | |||
Sequence: E → G | ||||||
Natural variant | VAR_011942 | 92 | in dbSNP:rs1804461 | |||
Sequence: D → G | ||||||
Natural variant | VAR_011943 | 98 | in dbSNP:rs1804464 | |||
Sequence: V → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 142 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MNVLLGSVVIFATFVTLCNA | ||||||
Chain | PRO_0000019268 | 21-114 | Beta-microseminoprotein | |||
Sequence: SCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVSTPVGYDKDNCQRIFKKEDCKYIVVEKKDPKKTCSVSEWII | ||||||
Disulfide bond | 22↔70 | |||||
Sequence: CYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCC | ||||||
Disulfide bond | 38↔62 | |||||
Sequence: CMDLKGNKHPINSEWQTDNCETCTC | ||||||
Disulfide bond | 57↔93 | |||||
Sequence: CETCTCYETEISCCTLVSTPVGYDKDNCQRIFKKEDC | ||||||
Disulfide bond | 60↔69 | |||||
Sequence: CTCYETEISC | ||||||
Disulfide bond | 84↔107 | |||||
Sequence: CQRIFKKEDCKYIVVEKKDPKKTC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Homodimer; Interacts with PI16.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P08118 | SGTA O43765 | 3 | EBI-10195681, EBI-347996 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
P08118-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NamePSP94
- Length114
- Mass (Da)12,865
- Last updated1988-08-01 v1
- ChecksumD0B13E436D70BB1D
P08118-2
- NamePSP57
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A590UJG9 | A0A590UJG9_HUMAN | MSMB | 118 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_003275 | 37-77 | in isoform PSP57 | |||
Sequence: KCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVSTPV → MFLHLWVMTKTTAKESSRRRTASISWWRRRTQKRPVLSVNG | ||||||
Alternative sequence | VSP_003276 | 78-114 | in isoform PSP57 | |||
Sequence: Missing | ||||||
Sequence conflict | 113 | in Ref. 14; AA sequence | ||||
Sequence: I → G |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M15885 EMBL· GenBank· DDBJ | AAA36635.1 EMBL· GenBank· DDBJ | mRNA | ||
M34376 EMBL· GenBank· DDBJ | AAA59871.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M34373 EMBL· GenBank· DDBJ | AAA59871.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M34374 EMBL· GenBank· DDBJ | AAA59871.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M34375 EMBL· GenBank· DDBJ | AAA59871.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X57928 EMBL· GenBank· DDBJ | CAA41002.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X57929 EMBL· GenBank· DDBJ | CAA41002.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X57930 EMBL· GenBank· DDBJ | CAA41002.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X57931 EMBL· GenBank· DDBJ | CAA41002.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
S67815 EMBL· GenBank· DDBJ | AAB29732.1 EMBL· GenBank· DDBJ | mRNA | ||
U22178 EMBL· GenBank· DDBJ | AAA83556.1 EMBL· GenBank· DDBJ | mRNA | ||
U78976 EMBL· GenBank· DDBJ | AAB37355.1 EMBL· GenBank· DDBJ | mRNA | ||
BT006816 EMBL· GenBank· DDBJ | AAP35462.1 EMBL· GenBank· DDBJ | mRNA | ||
CR457015 EMBL· GenBank· DDBJ | CAG33296.1 EMBL· GenBank· DDBJ | mRNA | ||
AL450342 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC005257 EMBL· GenBank· DDBJ | AAH05257.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ133356 EMBL· GenBank· DDBJ | CAB39325.1 EMBL· GenBank· DDBJ | Genomic DNA |