P07825 · SYPH_RAT

Function

function

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexcitatory synapse
Cellular Componentmembrane
Cellular Componentneuromuscular junction
Cellular Componentneuron projection
Cellular Componentneuron projection terminus
Cellular Componentneuron spine
Cellular Componentperinuclear region of cytoplasm
Cellular Componentpostsynaptic density
Cellular Componentpresynapse
Cellular Componentpresynaptic active zone
Cellular Componentpresynaptic membrane
Cellular Componentprotein-containing complex
Cellular ComponentSchaffer collateral - CA1 synapse
Cellular Componentsynapse
Cellular Componentsynaptic vesicle
Cellular Componentsynaptic vesicle membrane
Cellular Componentterminal bouton
Molecular Functioncholesterol binding
Molecular Functionidentical protein binding
Molecular Functionprotein domain specific binding
Molecular Functionprotein-containing complex binding
Molecular FunctionSH2 domain binding
Molecular FunctionSNARE binding
Molecular Functionsyntaxin-1 binding
Biological Processendocytosis
Biological Processmodulation of chemical synaptic transmission
Biological Processregulation of long-term neuronal synaptic plasticity
Biological Processregulation of neuronal synaptic plasticity
Biological Processregulation of opioid receptor signaling pathway
Biological Processregulation of short-term neuronal synaptic plasticity
Biological Processregulation of synaptic vesicle priming
Biological Processresponse to amyloid-beta
Biological Processsynaptic vesicle endocytosis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Synaptophysin
  • Alternative names
    • Major synaptic vesicle protein p38

Gene names

    • Name
      Syp

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P07825
  • Secondary accessions
    • Q499R3

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-19Cytoplasmic
Transmembrane20-43Helical
Topological domain44-101Vesicular
Transmembrane102-125Helical
Topological domain126-132Cytoplasmic
Transmembrane133-156Helical
Topological domain157-194Vesicular
Transmembrane195-218Helical
Topological domain219-307Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue.

Type
IDPosition(s)Description
ChainPRO_00001791631-307Synaptophysin
Glycosylation53N-linked (GlcNAc...) asparagine
Modified residue75Phosphotyrosine
Modified residue221Phosphothreonine
Modified residue273Phosphotyrosine
Modified residue289Phosphotyrosine

Post-translational modification

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Phosphorylated by SRC.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the brain with expression in the cerebrum and the cerebellum.

Developmental stage

Expressed in the spinal cord of newborn animals.

Interaction

Subunit

Homohexamer or homotetramer. Interacts with SRCIN1 (By similarity).
Interacts with VAMP2; the interaction is inhibit by interaction of VAPM2 with SEPT8 (PubMed:19196426).

Binary interactions

Type
Entry 1Entry 2Number of experimentsIntAct
BINARY P07825Itm2b Q5XIE84EBI-976085, EBI-15348306
BINARY P07825Oprm1 P335358EBI-976085, EBI-4392569
XENO P07825Srcin1 Q9QWI6-22EBI-976085, EBI-775607

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain15-222MARVEL
Region233-307Disordered
Region249-298Repeats, Gly-rich
Compositional bias290-307Polar residues

Domain

The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.

Sequence similarities

Belongs to the synaptophysin/synaptobrevin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    307
  • Mass (Da)
    33,311
  • Last updated
    1988-08-01 v1
  • Checksum
    A245E4F70BF0EAF0
MDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVEFEYPFRLHQVYFDAPSCVKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPMCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFMRAPPGAPEKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPASGGGGYGPQGDYGQQGYGQQGAPTSFSNQM

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6AQE3A0A8I6AQE3_RATSyp362
A0A0G2KAD8A0A0G2KAD8_RATSyp304

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias290-307Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X06177
EMBL· GenBank· DDBJ
CAA29543.1
EMBL· GenBank· DDBJ
mRNA
X06388
EMBL· GenBank· DDBJ
CAA29685.1
EMBL· GenBank· DDBJ
mRNA
M58396
EMBL· GenBank· DDBJ
AAA42196.1
EMBL· GenBank· DDBJ
Genomic DNA
M58402
EMBL· GenBank· DDBJ
AAA42196.1
EMBL· GenBank· DDBJ
Genomic DNA
M58401
EMBL· GenBank· DDBJ
AAA42196.1
EMBL· GenBank· DDBJ
Genomic DNA
M58399
EMBL· GenBank· DDBJ
AAA42196.1
EMBL· GenBank· DDBJ
Genomic DNA
BC099798
EMBL· GenBank· DDBJ
AAH99798.1
EMBL· GenBank· DDBJ
mRNA
X06655
EMBL· GenBank· DDBJ
CAA29854.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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