P07825 · SYPH_RAT
- ProteinSynaptophysin
- GeneSyp
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids307 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSynaptophysin
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP07825
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-19 | Cytoplasmic | |||
Transmembrane | 20-43 | Helical | |||
Topological domain | 44-101 | Vesicular | |||
Transmembrane | 102-125 | Helical | |||
Topological domain | 126-132 | Cytoplasmic | |||
Transmembrane | 133-156 | Helical | |||
Topological domain | 157-194 | Vesicular | |||
Transmembrane | 195-218 | Helical | |||
Topological domain | 219-307 | Cytoplasmic | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000179163 | 1-307 | Synaptophysin | ||
Glycosylation | 53 | N-linked (GlcNAc...) asparagine | |||
Modified residue | 75 | Phosphotyrosine | |||
Modified residue | 221 | Phosphothreonine | |||
Modified residue | 273 | Phosphotyrosine | |||
Modified residue | 289 | Phosphotyrosine | |||
Post-translational modification
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Phosphorylated by SRC.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the brain with expression in the cerebrum and the cerebellum.
Developmental stage
Expressed in the spinal cord of newborn animals.
Interaction
Subunit
Homohexamer or homotetramer. Interacts with SRCIN1 (By similarity).
Interacts with VAMP2; the interaction is inhibit by interaction of VAPM2 with SEPT8 (PubMed:19196426).
Interacts with VAMP2; the interaction is inhibit by interaction of VAPM2 with SEPT8 (PubMed:19196426).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P07825 | Itm2b Q5XIE8 | 4 | EBI-976085, EBI-15348306 | |
BINARY | P07825 | Oprm1 P33535 | 8 | EBI-976085, EBI-4392569 | |
XENO | P07825 | Srcin1 Q9QWI6-2 | 2 | EBI-976085, EBI-775607 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 15-222 | MARVEL | |||
Region | 233-307 | Disordered | |||
Region | 249-298 | Repeats, Gly-rich | |||
Compositional bias | 290-307 | Polar residues | |||
Domain
The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
Sequence similarities
Belongs to the synaptophysin/synaptobrevin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length307
- Mass (Da)33,311
- Last updated1988-08-01 v1
- ChecksumA245E4F70BF0EAF0
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6AQE3 | A0A8I6AQE3_RAT | Syp | 362 | ||
A0A0G2KAD8 | A0A0G2KAD8_RAT | Syp | 304 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 290-307 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X06177 EMBL· GenBank· DDBJ | CAA29543.1 EMBL· GenBank· DDBJ | mRNA | ||
X06388 EMBL· GenBank· DDBJ | CAA29685.1 EMBL· GenBank· DDBJ | mRNA | ||
M58396 EMBL· GenBank· DDBJ | AAA42196.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M58402 EMBL· GenBank· DDBJ | AAA42196.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M58401 EMBL· GenBank· DDBJ | AAA42196.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M58399 EMBL· GenBank· DDBJ | AAA42196.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC099798 EMBL· GenBank· DDBJ | AAH99798.1 EMBL· GenBank· DDBJ | mRNA | ||
X06655 EMBL· GenBank· DDBJ | CAA29854.1 EMBL· GenBank· DDBJ | mRNA |