P07560 · SEC4_YEAST

Function

function

Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle.

Features

Showing features for binding site.

121520406080100120140160180200
TypeIDPosition(s)Description
Binding site27-34GTP (UniProtKB | ChEBI)
Binding site75-79GTP (UniProtKB | ChEBI)
Binding site133-136GTP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcellular bud neck
Cellular Componentendoplasmic reticulum
Cellular Componentendosome
Cellular Componentincipient cellular bud site
Cellular Componentmating projection tip
Cellular Componentmitochondrial outer membrane
Cellular Componentmitochondrion
Cellular Componentplasma membrane
Cellular Componenttransport vesicle
Cellular Componenttransport vesicle membrane
Cellular Componentvesicle
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological Processascospore-type prospore assembly
Biological Processautophagy
Biological Processexocytosis
Biological ProcessGolgi to plasma membrane transport
Biological Processmembrane addition at site of cytokinesis
Biological Processprotein secretion
Biological Processvesicle fusion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ras-related protein SEC4
  • Alternative names
    • Suppressor of RHO3 protein 6

Gene names

    • Name
      SEC4
    • Synonyms
      SRO6
    • Ordered locus names
      YFL005W

Organism names

Accessions

  • Primary accession
    P07560
  • Secondary accessions
    • D6VTM4

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, modified residue, lipidation.

TypeIDPosition(s)Description
ChainPRO_00001213301-215
Modified residue201Phosphoserine
Modified residue204Phosphoserine
Lipidation214S-geranylgeranyl cysteine
Lipidation215S-geranylgeranyl cysteine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Interacts with the guanyl-nucleotide exchange factor SEC2. Interacts with SRO7, YIF1, YIP3, YIP4 and YIP5.

Binary interactions

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif49-57Effector region

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    215
  • Mass (Da)
    23,506
  • Last updated
    1988-08-01 v1
  • Checksum
    7DEDF7DCC7533BA7
MSGLRTVSASSGNGKSYDSIMKILLIGDSGVGKSCLLVRFVEDKFNPSFITTIGIDFKIKTVDINGKKVKLQLWDTAGQERFRTITTAYYRGAMGIILVYDVTDERTFTNIKQWFKTVNEHANDEAQLLLVGNKSDMETRVVTADQGEALAKELGIPFIESSAKNDDNVNEIFFTLAKLIQEKIDSNKLVGVGNGKEGNISINSGSGNSSKSNCC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M16507
EMBL· GenBank· DDBJ
AAA35032.1
EMBL· GenBank· DDBJ
Genomic DNA
D50617
EMBL· GenBank· DDBJ
BAA09233.1
EMBL· GenBank· DDBJ
Genomic DNA
AY692843
EMBL· GenBank· DDBJ
AAT92862.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006940
EMBL· GenBank· DDBJ
DAA12434.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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