P07507 · MGP_BOVIN
- ProteinMatrix Gla protein
- GeneMGP
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids103 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | collagen-containing extracellular matrix | |
Cellular Component | extracellular matrix | |
Cellular Component | extracellular region | |
Molecular Function | calcium ion binding | |
Biological Process | cartilage development | |
Biological Process | cell differentiation | |
Biological Process | ossification | |
Biological Process | regulation of bone mineralization |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMatrix Gla protein
- Short namesMGP
- Cleaved into 2 chains
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionP07507
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, modified residue, disulfide bond, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MKSLLLLSILAALAVAALC | ||||||
Chain | PRO_0000011105 | 20-98 | Matrix Gla protein short form | |||
Sequence: YESHESLESYEINPFINRRNANSFISPQQRWRAKAQERIRELNKPQYELNREACDDFKLCERYAMVYGYNAAYDRYFRQ | ||||||
Chain | PRO_0000011104 | 20-102 | Matrix Gla protein long form | |||
Sequence: YESHESLESYEINPFINRRNANSFISPQQRWRAKAQERIRELNKPQYELNREACDDFKLCERYAMVYGYNAAYDRYFRQRRGA | ||||||
Modified residue | 21 | 4-carboxyglutamate; partial | ||||
Sequence: E | ||||||
Modified residue | 22 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 25 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 28 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 56 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 60 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 67 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 71 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Disulfide bond | 73↔79 | |||||
Sequence: CDDFKLC | ||||||
Propeptide | PRO_0000011106 | 99-102 | Removed in short form; probably by carboxypeptidase N | |||
Sequence: RRGA | ||||||
Propeptide | PRO_0000011107 | 103 | Removed in long form; probably by carboxypeptidase H | |||
Sequence: K |
Post-translational modification
Requires vitamin K-dependent gamma-carboxylation for its function.
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 51-97 | Gla | ||||
Sequence: RAKAQERIRELNKPQYELNREACDDFKLCERYAMVYGYNAAYDRYFR |
Sequence similarities
Belongs to the osteocalcin/matrix Gla protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length103
- Mass (Da)12,217
- Last updated1988-08-01 v1
- Checksum86A89984F92BF38A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X07363 EMBL· GenBank· DDBJ | CAA30288.1 EMBL· GenBank· DDBJ | mRNA | ||
AF210379 EMBL· GenBank· DDBJ | AAF25880.1 EMBL· GenBank· DDBJ | mRNA | ||
AB098895 EMBL· GenBank· DDBJ | BAC56385.1 EMBL· GenBank· DDBJ | mRNA | ||
BC102587 EMBL· GenBank· DDBJ | AAI02588.1 EMBL· GenBank· DDBJ | mRNA |