Allele frequencies between a group of 191 ITP patients & controls showed no direct aetiological role for SNP (R307H) but it was associated with immunomodulatory treatment failure.
Nuclear matrix proteins such as mutant Pyst1 and nucleophosmin 1 were downregulated whereas eIF6 and beta-tubulin were upregulated during cell differentiation in hepatocarcinoma cells.
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