P07340 · AT1B1_RAT

  • Protein
    Sodium/potassium-transporting ATPase subunit beta-1
  • Gene
    Atp1b1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (PubMed:22328500).
Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (By similarity).
Involved in cell adhesion and establishing epithelial cell polarity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbasolateral plasma membrane
Cellular Componentcaveola
Cellular Componentintercalated disc
Cellular Componentlateral plasma membrane
Cellular Componentmembrane
Cellular Componentorganelle membrane
Cellular Componentplasma membrane
Cellular Componentsarcolemma
Cellular Componentsodium:potassium-exchanging ATPase complex
Cellular Componentsperm flagellum
Cellular ComponentT-tubule
Molecular FunctionATPase activator activity
Molecular FunctionATPase binding
Molecular FunctionP-type sodium:potassium-exchanging transporter activity
Molecular Functionprotein heterodimerization activity
Molecular Functionprotein kinase binding
Molecular Functionprotein-macromolecule adaptor activity
Biological ProcessATP metabolic process
Biological Processblastocyst development
Biological Processcardiac muscle contraction
Biological Processcell adhesion
Biological Processinnate immune response
Biological Processintracellular calcium ion homeostasis
Biological Processintracellular potassium ion homeostasis
Biological Processintracellular sodium ion homeostasis
Biological Processmembrane repolarization
Biological Processmetal ion transport
Biological Processmonoatomic cation transmembrane transport
Biological Processpositive regulation of potassium ion import across plasma membrane
Biological Processpositive regulation of sodium ion export across plasma membrane
Biological Processpotassium ion import across plasma membrane
Biological Processpotassium ion transport
Biological Processprotein localization to plasma membrane
Biological Processprotein stabilization
Biological Processregulation of calcium ion transmembrane transport
Biological Processregulation of cardiac muscle contraction by calcium ion signaling
Biological Processregulation of gene expression
Biological Processrelaxation of cardiac muscle
Biological Processresponse to hypoxia
Biological Processsodium ion export across plasma membrane
Biological Processsodium ion transmembrane transport
Biological Processsodium ion transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sodium/potassium-transporting ATPase subunit beta-1
  • Alternative names
    • Sodium/potassium-dependent ATPase subunit beta-1

Gene names

    • Name
      Atp1b1

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P07340
  • Secondary accessions
    • Q63062

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type II membrane protein
Apical cell membrane
; Single-pass type II membrane protein
Note: Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-34Cytoplasmic
Transmembrane35-62Helical; Signal-anchor for type II membrane protein
Topological domain63-304Extracellular

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, disulfide bond, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00002191001-304Sodium/potassium-transporting ATPase subunit beta-1
Modified residue11Phosphoserine
Modified residue101Phosphotyrosine
Disulfide bond126↔149
Glycosylation158N-linked (GlcNAc...) asparagine
Disulfide bond159↔175
Glycosylation193N-linked (GlcNAc...) asparagine
Disulfide bond214↔277
Glycosylation266N-linked (GlcNAc...) asparagine

Post-translational modification

Glutathionylated. N-glycosylated (PubMed:14749213).

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the brain, liver, testes and anterior prostate (at protein level).

Gene expression databases

Interaction

Subunit

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit (By similarity).
Interacts with catalytic subunit ATP12A (PubMed:14749213).
Interacts with regulatory subunit FXYD1 (PubMed:23532852).
Interacts with regulatory subunit FXYD3 (PubMed:15743908).
Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity).
Interacts with MLC1 (By similarity).
Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM (By similarity).
Interacts with KIRREL3 (By similarity).
Interacts with OBSCN (via protein kinase domain 1) (By similarity).
Interacts with TRAF3 and TRAF6 (By similarity).

Protein-protein interaction databases

Chemistry

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region191-304immunoglobulin-like

Domain

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    304
  • Mass (Da)
    35,202
  • Last updated
    1988-04-01 v1
  • Checksum
    86C3120F463B7B2B
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISELKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIIRFLEKYKDSAQKDDMIFEDCGSMPSEPKERGEFNHERGERKVCRFKLDWLGNCSGLNDESYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPLTMKYNPNVLPVQCTGKRDEDKDKVGNIEYFGMGGFYGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTLDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8L2Q0J0A0A8L2Q0J0_RATAtp1b1302
A0A096MJI9A0A096MJI9_RATAtp1b1248

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict183in Ref. 2; AAA40780

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M14137
EMBL· GenBank· DDBJ
AAA40781.1
EMBL· GenBank· DDBJ
mRNA
J02701
EMBL· GenBank· DDBJ
AAA40780.1
EMBL· GenBank· DDBJ
mRNA
BC078902
EMBL· GenBank· DDBJ
AAH78902.1
EMBL· GenBank· DDBJ
mRNA
X63375
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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