P07071 · NRDD_BPT4

Function

function

Catalyzes the conversion of ribonucleotides into deoxyribonucleotides, which are required for DNA synthesis and repair.

Catalytic activity

Activity regulation

Activated under anaerobic conditions by NrdG, a tightly associated activase. Activation involves the formation of a glycyl radical at Gly-580.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site64dCTP 1 (UniProtKB | ChEBI)
Binding site64dGTP 1 (UniProtKB | ChEBI)
Binding site66dCTP 1 (UniProtKB | ChEBI)
Binding site66dGTP 1 (UniProtKB | ChEBI)
Binding site67dGTP 1 (UniProtKB | ChEBI)
Binding site100dATP (UniProtKB | ChEBI)
Binding site100dCTP 2 (UniProtKB | ChEBI)
Binding site100dGTP 2 (UniProtKB | ChEBI)
Binding site100dTTP (UniProtKB | ChEBI)
Binding site103dATP (UniProtKB | ChEBI)
Binding site103dCTP 2 (UniProtKB | ChEBI)
Binding site103dGTP 2 (UniProtKB | ChEBI)
Binding site114dATP (UniProtKB | ChEBI)
Binding site114dCTP 2 (UniProtKB | ChEBI)
Binding site114dTTP (UniProtKB | ChEBI)
Binding site146dATP (UniProtKB | ChEBI)
Binding site146dCTP 2 (UniProtKB | ChEBI)
Binding site146dGTP 2 (UniProtKB | ChEBI)
Binding site146dTTP (UniProtKB | ChEBI)
Binding site445-448dCTP 1 (UniProtKB | ChEBI)
Binding site447dGTP 1 (UniProtKB | ChEBI)
Binding site448dGTP 1 (UniProtKB | ChEBI)
Binding site543Zn2+ (UniProtKB | ChEBI)
Binding site546Zn2+ (UniProtKB | ChEBI)
Binding site561Zn2+ (UniProtKB | ChEBI)
Binding site564Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentanaerobic ribonucleoside-triphosphate reductase complex
Molecular Functionmetal ion binding
Molecular Functionribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Molecular Functionribonucleoside-triphosphate reductase (thioredoxin) activity
Biological Process2'-deoxyribonucleotide biosynthetic process
Biological ProcessDNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Anaerobic ribonucleoside-triphosphate reductase
  • EC number
  • Alternative names
    • Class III ribonucleoside-triphosphate reductase

Gene names

    • Name
      nrdD
    • Synonyms
      49.1, 55.11/55.13, SUNY

Organism names

Accessions

  • Primary accession
    P07071
  • Secondary accessions
    • P07073
    • Q38428
    • Q9T0V5

Proteomes

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis580Lacks both glycyl radical and activity. Does not affect interaction with NrdG.

Chemistry

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001666861-605Anaerobic ribonucleoside-triphosphate reductase
Modified residue580Glycine radical

Keywords

Interaction

Subunit

Homodimer. Forms a tetramer composed of two NrdD and two NrdG subunits.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain482-605Glycine radical

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    605
  • Mass (Da)
    67,957
  • Last updated
    2002-01-23 v4
  • Checksum
    C5F29CE03126800B
MTIEKEIEGLIHKTNKDLLNENANKDSRVFPTQRDLMAGIVSKHIAKNMVPSFIMKAHESGIIHVHDIDYSPALPFTNCCLVDLKGMLENGFKLGNAQIETPKSIGVATAIMAQITAQVASHQYGGTTFANVDKVLSPYVKRTYAKHIEDAEKWQIADALNYAQSKTEKDVYDAFQAYEYEVNTLFSSNGQTPFVTITFGTGTDWTERMIQKAILKNRIKGLGRDGITPIFPKLVMFVEEGVNLYKDDPNYDIKQLALECASKRMYPDIISAKNNKAITGSSVPVSPMGCRSFLSVWKDSTGNEILDGRNNLGVVTLNLPRIALDSYIGTQFNEQKFVELFNERMDLCFEALMCRISSLKGVKATVAPILYQEGAFGVRLKPDDDIIELFKNGRSSVSLGYIGIHELNILVGRDIGREILTKMNAHLKQWTERTGFAFSLYSTPAENLCYRFCKLDTEKYGSVKDVTDKGWYTNSFHVSVEENITPFEKISREAPYHFIATGGHISYVELPDMKNNLKGLEAVWDYAAQHLDYFGVNMPVDKCFTCGSTHEMTPTENGFVCSICGETDPKKMNTIRRTCGYLGNPNERGFNLGKNKEIMHRVKHQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y00122
EMBL· GenBank· DDBJ
CAA68308.1
EMBL· GenBank· DDBJ
Genomic DNA
Y00122
EMBL· GenBank· DDBJ
CAA68310.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AF158101
EMBL· GenBank· DDBJ
AAD42633.1
EMBL· GenBank· DDBJ
Genomic DNA
X12629
EMBL· GenBank· DDBJ
CAA31150.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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