P06955 · NP_BPPZA

Function

function

Histone-like nucleoprotein that binds to the viral dsDNA and responsible for wrapping and compacting the viral DNA about 4-fold. Forms a nucleoprotein complex in which the DNA adopts a right-handed toroidal conformation winding around a protein core. Binds ito most, if not all, the viral genome, although with different affinity, the highest one corresponding to the genome ends. The formation of the nucleoprotein complex at the genome ends, activates the initiation of viral DNA replication. The binding of p6 would recruit the complex formed by the TP and the DNA polymerase to the origin. Protein p6 also represses early transcription from promoter C2, and, together with protein p4, represses transcription from promoters A2b and A2c and activates late transcription from promoter A3. Protein p6 is therefore involved in the early to late transcription switch. The formation of the nucleoprotein complex at the right end of the phage genome where the early promoter C2 is located affects local topology, which may contribute to the promoter repression.

Features

Showing features for dna binding.

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MAKMMQREITKTTVNVAKMVMVDGEVQVEQLPSETFVGNLSMEQAQWRMKRKYKGEPVQVVSVEPNTEVYELPVEKFLEVATVRVEKEDSEEQVAE
TypeIDPosition(s)Description
DNA binding1-19

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionDNA binding
Biological Processchromosome condensation
Biological ProcessDNA replication
Biological Processviral DNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Histone-like protein p6
  • Alternative names
    • Double-stranded DNA-binding protein
    • Double-stranded DNA-binding protein p6
    • Gene product 6
      (gp6
      )
    • Histone-like binding protein
    • Nucleoid-associated protein p6
    • Protein p6

Gene names

    • Name
      6

Organism names

Accessions

  • Primary accession
    P06955

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001065691-96Histone-like protein p6

Expression

Keywords

Interaction

Subunit

Homodimer. Homomultimer. Binds to double-stranded DNA giving rise to multimeric nucleoprotein complexes. Binding specificity for the viral DNA is based on supercoiling, the viral genome having a negative superhelicity lower than that of plasmid DNA. Interacts with the DNA replication protein p17; this interaction optimizes the binding of protein p6 at the viral DNA ends, thus favoring the initiation of replication.

Structure

3D structure databases

Family & Domains

Domain

The N-terminus is involved in DNA-binding.

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    96
  • Mass (Da)
    11,050
  • Last updated
    1988-01-01 v1
  • Checksum
    49DF291A99EF4F8E
MAKMMQREITKTTVNVAKMVMVDGEVQVEQLPSETFVGNLSMEQAQWRMKRKYKGEPVQVVSVEPNTEVYELPVEKFLEVATVRVEKEDSEEQVAE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M11813
EMBL· GenBank· DDBJ
AAA88473.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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