P06821 · M2_I34A1
- ProteinMatrix protein 2
- GeneM
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Miscellaneous
Activity regulation
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 37 | Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter | ||||
Sequence: H | ||||||
Site | 41 | Seems to be involved in pH gating | ||||
Sequence: W |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | host cell plasma membrane | |
Cellular Component | plasma membrane | |
Cellular Component | virion membrane | |
Molecular Function | monoatomic ion channel activity | |
Molecular Function | proton transmembrane transporter activity | |
Biological Process | protein complex oligomerization | |
Biological Process | suppression by virus of host autophagy | |
Biological Process | symbiont genome entry into host cell via pore formation in plasma membrane | |
Biological Process | uncoating of virus |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMatrix protein 2
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Alphainfluenzavirus > Alphainfluenzavirus influenzae > Influenza A virus
- Virus hosts
Accessions
- Primary accessionP06821
- Secondary accessions
Proteomes
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-22 | Virion surface | ||||
Sequence: MSLLTEVETPIRNEWGCRCNGS | ||||||
Transmembrane | 23-43 | Helical; Signal-anchor for type III membrane protein | ||||
Sequence: SDPLAIAANIIGILHLILWIL | ||||||
Topological domain | 44-97 | Intravirion | ||||
Sequence: DRLFFKCIYRRFKYGLKGGPSTEGVPKSMREEYRKEQQSAVDADDGHFVSIELE |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 10 | in strain: A/Puerto Rico/8/34/Mount Sinai/Wi-M2-P10H | ||||
Sequence: P → H | ||||||
Natural variant | 10 | in strain: A/Puerto Rico/8/34/Mount Sinai/Wi-M2-P10L | ||||
Sequence: P → L | ||||||
Natural variant | 27 | in strain: A/Puerto Rico/8/34/Mount Sinai/Wi, A/Puerto Rico/8/34/Mount Sinai/Wi-M2-P10L and A/Puerto Rico/8/34/Mount Sinai/Wi-M2-P10H | ||||
Sequence: A → T | ||||||
Natural variant | 39 | in strain: A/Puerto Rico/8/34/Mount Sinai/Wi, A/Puerto Rico/8/34/Mount Sinai/Wi-M2-P10L and A/Puerto Rico/8/34/Mount Sinai/Wi-M2-P10H | ||||
Sequence: I → T |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, disulfide bond, glycosylation, lipidation, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000078890 | 1-97 | Matrix protein 2 | |||
Sequence: MSLLTEVETPIRNEWGCRCNGSSDPLAIAANIIGILHLILWILDRLFFKCIYRRFKYGLKGGPSTEGVPKSMREEYRKEQQSAVDADDGHFVSIELE | ||||||
Disulfide bond | 17 | Interchain (with C-17) | ||||
Sequence: C | ||||||
Disulfide bond | 19 | Interchain (with C-19) | ||||
Sequence: C | ||||||
Glycosylation | 20 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Lipidation | 50 | S-palmitoyl cysteine; by host | ||||
Sequence: C | ||||||
Modified residue | 64 | Phosphoserine; by host | ||||
Sequence: S | ||||||
Modified residue | 82 | Phosphoserine; by host | ||||
Sequence: S | ||||||
Modified residue | 93 | Phosphoserine; by host | ||||
Sequence: S |
Keywords
- PTM
PTM databases
Interaction
Subunit
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
XENO | P06821 | EIF2B4 Q9UI10 | 3 | EBI-2547404, EBI-2340132 | |
XENO | P06821 | ZMPSTE24 O75844 | 2 | EBI-2547404, EBI-1056377 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 59-88 | Disordered | ||||
Sequence: LKGGPSTEGVPKSMREEYRKEQQSAVDADD | ||||||
Compositional bias | 70-88 | Basic and acidic residues | ||||
Sequence: KSMREEYRKEQQSAVDADD |
Domain
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing. Only the first 9 residues are shared by the 2 isoforms.
P06821-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameM2
- Length97
- Mass (Da)11,045
- Last updated1988-11-01 v1
- Checksum85858F6E84A97AB8
P03485-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameM1
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 27 | in Ref. 5; ABD77677 | ||||
Sequence: A → I | ||||||
Sequence conflict | 30 | in Ref. 5; ABD77677 | ||||
Sequence: A → S | ||||||
Sequence conflict | 54 | in Ref. 5; ABD77677 | ||||
Sequence: R → L | ||||||
Sequence conflict | 61 | in Ref. 5; ABD77677 | ||||
Sequence: G → R | ||||||
Compositional bias | 70-88 | Basic and acidic residues | ||||
Sequence: KSMREEYRKEQQSAVDADD | ||||||
Sequence conflict | 77 | in Ref. 5; ABD77677 | ||||
Sequence: R → Q |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
V01099 EMBL· GenBank· DDBJ | CAA24283.1 EMBL· GenBank· DDBJ | Genomic RNA | Sequence problems. | |
AF389121 EMBL· GenBank· DDBJ | AAM75162.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
EF467824 EMBL· GenBank· DDBJ | ABO21713.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY768951 EMBL· GenBank· DDBJ | AAV41244.1 EMBL· GenBank· DDBJ | mRNA | ||
AY768952 EMBL· GenBank· DDBJ | AAV41245.1 EMBL· GenBank· DDBJ | mRNA | ||
AY768953 EMBL· GenBank· DDBJ | AAV41246.1 EMBL· GenBank· DDBJ | mRNA | ||
CY009445 EMBL· GenBank· DDBJ | ABD77677.1 EMBL· GenBank· DDBJ | Genomic RNA |