P06281 · RENI1_MOUSE

Function

function

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Catalytic activity

  • Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
    EC:3.4.23.15 (UniProtKB | ENZYME | Rhea)

Activity regulation

Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.

Features

Showing features for active site.

140250100150200250300350400
TypeIDPosition(s)Description
Active site102
Active site287

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical part of cell
Cellular Componentextracellular space
Cellular Componentmembrane
Molecular Functionaspartic-type endopeptidase activity
Molecular Functionendopeptidase activity
Molecular Functioninsulin-like growth factor receptor binding
Molecular Functionsignaling receptor binding
Biological Processamyloid-beta metabolic process
Biological Processangiotensin maturation
Biological Processcell maturation
Biological Processcellular response to xenobiotic stimulus
Biological Processdrinking behavior
Biological Processhormone-mediated signaling pathway
Biological Processjuxtaglomerular apparatus development
Biological Processmale gonad development
Biological Processmesonephros development
Biological Processregulation of blood pressure
Biological Processregulation of blood volume by renin-angiotensin
Biological Processregulation of MAPK cascade
Biological Processrenin-angiotensin regulation of aldosterone production
Biological Processresponse to cAMP
Biological Processresponse to cGMP
Biological Processresponse to immobilization stress
Biological Processresponse to lipopolysaccharide
Biological Processresponse to xenobiotic stimulus

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Renin-1
  • EC number
  • Alternative names
    • Angiotensinogenase
    • Kidney renin

Gene names

    • Name
      Ren1
    • Synonyms
      Ren, Ren-1

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/10
    • DBA/2J
    • C57BL/6J
    • C57BL/10ROS X C3H/HEROS
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P06281
  • Secondary accessions
    • P97911
    • Q543E5
    • Q62153
    • Q62154

Proteomes

Organism-specific databases

Subcellular Location

Secreted
Membrane
Note: Associated to membranes via binding to ATP6AP2.

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant58in allele Ren-1D
Natural variant68in allele Ren-1D
Natural variant160in allele Ren-1D; requires 2 nucleotide substitutions
Natural variant315in allele Ren-1D
Natural variant352in allele Ren-1D

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 53 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for signal, propeptide, glycosylation, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-21
PropeptidePRO_000002608922-71Activation peptide
Glycosylation69N-linked (GlcNAc...) asparagine
ChainPRO_000002609072-402Renin-1
Disulfide bond115↔122
Glycosylation139N-linked (GlcNAc...) asparagine
Disulfide bond278↔282
Glycosylation320N-linked (GlcNAc...) asparagine
Disulfide bond321↔358

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Kidney.

Induction

Renal renin is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration.

Gene expression databases

Interaction

Subunit

Interacts with ATP6AP2.

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain84-399Peptidase A1

Sequence similarities

Belongs to the peptidase A1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    402
  • Mass (Da)
    44,343
  • Last updated
    1988-01-01 v1
  • Checksum
    D42920B555E97A38
MDRRRMPLWALLLLWSPCTFSLPTRTATFERIPLKKMPSVREILEERGVDMTRLSAEWGVFTKRPSLTNLTSPVVLTNYLNTQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGSDFTIHYGSGRVKGFLSQDSVTVGGITVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEEVFSVYYNRGSHLLGGEVVLGGSDPQHYQGNFHYVSISKTDSWQITMKGVSVGSSTLLCEEGCAVVVDTGSSFISAPTSSLKLIMQALGAKEKRIEEYVVNCSQVPTLPDISFDLGGRAYTLSSTDYVLQYPNRRDKLCTLALHAMDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q9R259Q9R259_MOUSERen144

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict6-23in Ref. 1
Sequence conflict24in Ref. 1
Sequence conflict163in Ref. 1

Polymorphism

In inbred mouse strains, there are at least two alleles which can occur at the Ren1 locus: Ren-1D and Ren-1C. The sequence shown is that of Ren-1C.
Present as a single-copy gene in strains such as BALB/c and C57BL/6 while some strains such as Swiss and Akr contain two copies.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X00810
EMBL· GenBank· DDBJ
CAA25391.1
EMBL· GenBank· DDBJ
Genomic DNA
X00811
EMBL· GenBank· DDBJ
CAA25391.1
EMBL· GenBank· DDBJ
Genomic DNA
X00812
EMBL· GenBank· DDBJ
CAA25391.1
EMBL· GenBank· DDBJ
Genomic DNA
X00813
EMBL· GenBank· DDBJ
CAA25391.1
EMBL· GenBank· DDBJ
Genomic DNA
X00814
EMBL· GenBank· DDBJ
CAA25391.1
EMBL· GenBank· DDBJ
Genomic DNA
X00815
EMBL· GenBank· DDBJ
CAA25391.1
EMBL· GenBank· DDBJ
Genomic DNA
X00816
EMBL· GenBank· DDBJ
CAA25391.1
EMBL· GenBank· DDBJ
Genomic DNA
X00850
EMBL· GenBank· DDBJ
CAA25391.1
EMBL· GenBank· DDBJ
Genomic DNA
X00851
EMBL· GenBank· DDBJ
CAA25391.1
EMBL· GenBank· DDBJ
Genomic DNA
X16642
EMBL· GenBank· DDBJ
CAA34636.1
EMBL· GenBank· DDBJ
mRNA
K02596
EMBL· GenBank· DDBJ
AAA40045.1
EMBL· GenBank· DDBJ
Genomic DNA
M32352
EMBL· GenBank· DDBJ
AAA40043.1
EMBL· GenBank· DDBJ
Genomic DNA
AK052685
EMBL· GenBank· DDBJ
BAC35094.1
EMBL· GenBank· DDBJ
mRNA
AK085309
EMBL· GenBank· DDBJ
BAC39418.1
EMBL· GenBank· DDBJ
mRNA
BC061053
EMBL· GenBank· DDBJ
AAH61053.1
EMBL· GenBank· DDBJ
mRNA
K02800
EMBL· GenBank· DDBJ
AAA40044.1
EMBL· GenBank· DDBJ
Genomic DNA
M34190
EMBL· GenBank· DDBJ
AAA40042.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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