P06281 · RENI1_MOUSE
- ProteinRenin-1
- GeneRen1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids402 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Catalytic activity
Activity regulation
Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 102 | |||||
Sequence: D | ||||||
Active site | 287 | |||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameRenin-1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP06281
- Secondary accessions
Proteomes
Organism-specific databases
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 58 | in allele Ren-1D | ||||
Sequence: W → R | ||||||
Natural variant | 68 | in allele Ren-1D | ||||
Sequence: T → I | ||||||
Natural variant | 160 | in allele Ren-1D; requires 2 nucleotide substitutions | ||||
Sequence: S → V | ||||||
Natural variant | 315 | in allele Ren-1D | ||||
Sequence: E → D | ||||||
Natural variant | 352 | in allele Ren-1D | ||||
Sequence: N → Y |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 53 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for signal, propeptide, glycosylation, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MDRRRMPLWALLLLWSPCTFS | ||||||
Propeptide | PRO_0000026089 | 22-71 | Activation peptide | |||
Sequence: LPTRTATFERIPLKKMPSVREILEERGVDMTRLSAEWGVFTKRPSLTNLT | ||||||
Glycosylation | 69 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Chain | PRO_0000026090 | 72-402 | Renin-1 | |||
Sequence: SPVVLTNYLNTQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGSDFTIHYGSGRVKGFLSQDSVTVGGITVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEEVFSVYYNRGSHLLGGEVVLGGSDPQHYQGNFHYVSISKTDSWQITMKGVSVGSSTLLCEEGCAVVVDTGSSFISAPTSSLKLIMQALGAKEKRIEEYVVNCSQVPTLPDISFDLGGRAYTLSSTDYVLQYPNRRDKLCTLALHAMDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR | ||||||
Disulfide bond | 115↔122 | |||||
Sequence: CSRLYLAC | ||||||
Glycosylation | 139 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 278↔282 | |||||
Sequence: CEEGC | ||||||
Glycosylation | 320 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 321↔358 | |||||
Sequence: CSQVPTLPDISFDLGGRAYTLSSTDYVLQYPNRRDKLC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Kidney.
Induction
Renal renin is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 84-399 | Peptidase A1 | ||||
Sequence: YYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGSDFTIHYGSGRVKGFLSQDSVTVGGITVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEEVFSVYYNRGSHLLGGEVVLGGSDPQHYQGNFHYVSISKTDSWQITMKGVSVGSSTLLCEEGCAVVVDTGSSFISAPTSSLKLIMQALGAKEKRIEEYVVNCSQVPTLPDISFDLGGRAYTLSSTDYVLQYPNRRDKLCTLALHAMDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFA |
Sequence similarities
Belongs to the peptidase A1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length402
- Mass (Da)44,343
- Last updated1988-01-01 v1
- ChecksumD42920B555E97A38
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9R259 | Q9R259_MOUSE | Ren1 | 44 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 6-23 | in Ref. 1 | ||||
Sequence: Missing | ||||||
Sequence conflict | 24 | in Ref. 1 | ||||
Sequence: T → I | ||||||
Sequence conflict | 163 | in Ref. 1 | ||||
Sequence: V → VSRV |
Polymorphism
In inbred mouse strains, there are at least two alleles which can occur at the Ren1 locus: Ren-1D and Ren-1C. The sequence shown is that of Ren-1C.
Present as a single-copy gene in strains such as BALB/c and C57BL/6 while some strains such as Swiss and Akr contain two copies.
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X00810 EMBL· GenBank· DDBJ | CAA25391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X00811 EMBL· GenBank· DDBJ | CAA25391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X00812 EMBL· GenBank· DDBJ | CAA25391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X00813 EMBL· GenBank· DDBJ | CAA25391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X00814 EMBL· GenBank· DDBJ | CAA25391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X00815 EMBL· GenBank· DDBJ | CAA25391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X00816 EMBL· GenBank· DDBJ | CAA25391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X00850 EMBL· GenBank· DDBJ | CAA25391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X00851 EMBL· GenBank· DDBJ | CAA25391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X16642 EMBL· GenBank· DDBJ | CAA34636.1 EMBL· GenBank· DDBJ | mRNA | ||
K02596 EMBL· GenBank· DDBJ | AAA40045.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M32352 EMBL· GenBank· DDBJ | AAA40043.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK052685 EMBL· GenBank· DDBJ | BAC35094.1 EMBL· GenBank· DDBJ | mRNA | ||
AK085309 EMBL· GenBank· DDBJ | BAC39418.1 EMBL· GenBank· DDBJ | mRNA | ||
BC061053 EMBL· GenBank· DDBJ | AAH61053.1 EMBL· GenBank· DDBJ | mRNA | ||
K02800 EMBL· GenBank· DDBJ | AAA40044.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M34190 EMBL· GenBank· DDBJ | AAA40042.1 EMBL· GenBank· DDBJ | Genomic DNA |