A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases.Koga Y., Caccia N., Toyonaga B., Spolski R., Yanagi Y., Yoshikai Y., Mak T.W.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEur. J. Immunol. 16:1643-1646 (1986)Cited in1
Structure and expression of lck transcripts in human lymphoid cells.Perlmutter R.M., Marth J.D., Lewis D.B., Peet R., Ziegler S.F., Wilson C.B.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Cell. Biochem. 38:117-126 (1988)Cited in1
Structure of the human lck gene: differences in genomic organisation within src-related genes affect only N-terminal exons.Rouer E., van Huynh T., de Souza S.L., Lang M.C., Fischer S., Benarous R.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGene 84:105-113 (1989)Cited in1
Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia.Wright D.D., Sefton B.M., Kamps M.P.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-28; GLN-LYS-PRO-232 INS; VAL-353 AND LEU-447, PHOSPHORYLATION AT TYR-394 AND TYR-505TissueLeukemiaCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 14:2429-2437 (1994)Cited in1
An aberrant lck mRNA in two human T-cell lines.Vogel L.B., Arthur R., Fujita D.J.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), ALTERNATIVE SPLICINGTissueLeukemic T-cellCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochim. Biophys. Acta 1264:168-172 (1995)Cited in1
No association between lck gene polymorphisms and protein level in type 1 diabetes.Nervi S., Nicodeme S., Gartioux C., Atlan C., Lathrop M., Reviron D., Naquet P., Matsuda F., Imbert J., Vialettes B.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCDiabetes 51:3326-3330 (2002)Cited in1Mapped to6
The DNA sequence and biological annotation of human chromosome 1.Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K.[...], Bentley D.R.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 441:315-321 (2006)Cited in99+99+
No title available.Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H.[...], Venter J.C.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (SEP-2005)Cited in99+
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)TissueLymphCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line.Garvin A.M., Pawar S., Marth J.D., Perlmutter R.M.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 8:3058-3064 (1988)Cited in2Mapped to3
Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcripts in T cells.Takadera T., Leung S., Gernone A., Koga Y., Takihara Y., Miyamoto N.G., Mak T.W.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 9:2173-2180 (1989)Cited in1
Defective recruitment and activation of ZAP-70 in common variable immunodeficiency patients with T cell defects.Boncristiano M., Majolini M.B., D'Elios M.M., Pacini S., Valensin S., Ulivieri C., Amedei A., Falini B., Del Prete G.[...], Baldari C.T.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] OF 14-509TissuePeripheral blood lymphocyteCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEur. J. Immunol. 30:2632-2638 (2000)Cited in1
Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines.Veillette A., Foss F.M., Sausville E.A., Bolen J.B., Rosen N.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] OF 368-509CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCOncogene Res. 1:357-374 (1987)Cited in1
Human T lymphocytes express a protein-tyrosine kinase homologous to p56LSTRA.Trevillyan J.M., Lin Y., Chen S.J., Phillips C.A., Canna C., Linna T.J.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] OF 375-509CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochim. Biophys. Acta 888:286-295 (1986)Cited in1
The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.Bergman M., Mustelin T., Oetken C., Partanen J., Flint N.A., Amrein K.E., Autero M., Burn P., Alitalo K.View abstractCited forPHOSPHORYLATION AT TYR-505CategoriesPTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEMBO J. 11:2919-2924 (1992)Cited in2
The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes.Vogel L.B., Fujita D.J.View abstractCited forINTERACTION WITH PI3KCategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 13:7408-7417 (1993)Cited in1
p70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T-lymphocytes.Vogel L.B., Fujita D.J.View abstractCited forINTERACTION WITH KHDRBS1CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 270:2506-2511 (1995)Cited in1Mapped to1
Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.Park I., Chung J., Walsh C.T., Yun Y., Strominger J.L., Shin J.View abstractCited forINTERACTION WITH SQSTM1, MUTAGENESIS OF SER-59 AND ARG-154CategoriesDisease & Variants, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 92:12338-12342 (1995)Cited in3
Detection of a physical and functional interaction between Csk and Lck which involves the SH2 domain of Csk and is mediated by autophosphorylation of Lck on tyrosine 394.Bougeret C., Delaunay T., Romero F., Jullien P., Sabe H., Hanafusa H., Benarous R., Fischer S.View abstractCited forPHOSPHORYLATION AT TYR-505 BY CSK, AUTOPHOSPHORYLATIONCategoriesPTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 271:7465-7472 (1996)Cited in1Mapped to1
Human immunodeficiency virus type 1 Nef binds directly to LCK and mitogen- activated protein kinase, inhibiting kinase activity.Greenway A.L., Azad A., Mills J., McPhee D.A.View abstractCited forINTERACTION WITH HIV-1 NEF (MICROBIAL INFECTION)CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Virol. 70:6701-6708 (1996)Cited in4
Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.Braunger J., Schleithoff L., Schulz A.S., Kessler H., Lammers R., Ullrich A., Bartram C.R., Janssen J.W.View abstractCited forINTERACTION WITH AXLCategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCOncogene 14:2619-2631 (1997)Cited in6
Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products.Isakov N., Biesinger B.View abstractCited forREVIEWSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEur. J. Biochem. 267:3413-3421 (2000)Cited in1
The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling.Hawash I.Y., Hu X.E., Adal A., Cassady J.M., Geahlen R.L., Harrison M.L.View abstractCited forINTERACTION WITH CD48CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochim. Biophys. Acta 1589:140-150 (2002)Cited in2
BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression.Nikolova M., Marie-Cardine A., Boumsell L., Bensussan A.View abstractCited forSUBUNIT, INTERACTION WITH CD160CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCInt. Immunol. 14:445-451 (2002)Cited in3Mapped to1
Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.Yasuda K., Nagafuku M., Shima T., Okada M., Yagi T., Yamada T., Minaki Y., Kato A., Tani-Ichi S.[...], Kosugi A.View abstractCited forSUBCELLULAR LOCATIONCategoriesSubcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Immunol. 169:2813-2817 (2002)Cited in6Mapped to12