P06218 · NTRB_KLEOX
- ProteinSensory histidine kinase/phosphatase NtrB
- GenentrB
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids349 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC.
Catalytic activity
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | hydrolase activity | |
Molecular Function | phosphorelay sensor kinase activity | |
Biological Process | nitrogen fixation | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSensory histidine kinase/phosphatase NtrB
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionP06218
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000074825 | 1-349 | Sensory histidine kinase/phosphatase NtrB | |||
Sequence: MATGTLPDAGQILNSLINSILLVDDDLAVHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIGLMQESLAAGQGFTDNEVTLVIDGRSHILSLTAQRLPEGYILLEMAPMDNQRRLSQEQLQHAQQIAARDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPALMEYTKVIIEQADRLRNLVDRLLGPQHPGMHVTESIHKVAERVVKLVSMELPDNVKLVRDYDPSLPELPHDPDQIEQVLLNIVRNALQALGPEGGEITLRTRTAFQLTLHGVRYRLAARIDVEDNGPGIPSHLQDTLFYPMVSGREGGTGLGLSIARSLIDQHSGKIEFTSWPGHTEFSVYLPIRK | ||||||
Modified residue | 139 | Phosphohistidine; by autocatalysis | ||||
Sequence: H |
Post-translational modification
Autophosphorylated.
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-78 | PAS | ||||
Sequence: TLPDAGQILNSLINSILLVDDDLAVHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIGLMQESLAAGQGFTD | ||||||
Domain | 136-349 | Histidine kinase | ||||
Sequence: GLAHEIKNPLGGLRGAAQLLSKALPDPALMEYTKVIIEQADRLRNLVDRLLGPQHPGMHVTESIHKVAERVVKLVSMELPDNVKLVRDYDPSLPELPHDPDQIEQVLLNIVRNALQALGPEGGEITLRTRTAFQLTLHGVRYRLAARIDVEDNGPGIPSHLQDTLFYPMVSGREGGTGLGLSIARSLIDQHSGKIEFTSWPGHTEFSVYLPIRK |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length349
- Mass (Da)38,409
- Last updated1988-01-01 v1
- Checksum2CECDE3BA36395F2